Obesity and Coronary Artery Disease: An Updated Systematic Review 2022
Open accessAbstract
The primary goal is to identify the pathogenesis of cardiovascular illnesses in obese patients. Articles were extracted using the MeSH search approach from PubMed and Google Scholar databases. Inclusion and exclusion criteria were used, and duplicates were eliminated. Eight publications were finally included in this research study after two authors independently completed the quality check appraisal. Seven observational studies and one narrative review were found in our search. The publications evaluated the risk of coronary artery disease in metabolically healthy obese people with that of unhealthy obese adults and evaluated the effects of adipose tissue-mediated inflammation. Additionally, they offered several explanations for the obesity problem. Studies have indicated that adipocytokines and their pro-inflammatory cytokines have significantly affected the development of cardiovascular disease in obese subjects. The relationship between metabolically unhealthy people with increased risk for coronary artery disease (CAD) is unclear. It has also been shown that metabolically healthy obese persons are still at risk for developing coronary artery disease (CAD), as explained in certain studies in which inflammation plays a vital role in obese people. There hasn't been much data on the advantages of being physically active in overweight people, but obese people have to change their lifestyle as a first measure.
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Given existing evidence that even non-MetS obese individuals face elevated cardiovascular risk, these false positives may represent a clinically meaningful subgroup who could benefit from earlier lifestyle or medical interventions.
“Given existing evidence that even non-MetS obese individuals face elevated cardiovascular risk [43–45], these so-called “false positives” may represent a clinically meaningful subgroup who could benefit from earlier lifestyle or medical interventions.”
From Machine learning with the body roundness index and associated indicators: a new approach to predicting metabolic syndrome (2025) · cites this paper as [43]
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- Authors
- Manoharan, M. P., Raja, R., Jamil, A., Csendes, D., Gutlapalli, S. D., Prakash, K., Swarnakari, K. M., Bai, M., Desai, D. M., Desai, A., & Penumetcha, S. S.
- Affiliations
- University of California, Riverside (US)
- Corresponding author
- Manoharan, Mohana Priya
- Venue
- Cureus
- Published
- 2022-09-23
- Volume
- 14
- Issue
- 9
- Pages
- e29480-e29480
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC9588166
- OpenAlex
- W4297002008
- Cited by
- 36
- References
- 31
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 14 · 2023: 7
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, coronary artery disease, metabolically healthy obesity, metabolically unhealthy obesity, adipose tissue inflammation, adipokines, inflammatory cytokines, cardiovascular risk, physical activity, lifestyle modification
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