Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience
Open accessAbstract
Introduction Ehlers-Danlos syndrome (EDS), specifically the hypermobility type (hEDS), is associated with a variety of gastrointestinal (GI) conditions. This study aims to evaluate the prevalence of and factors associated with gut dysmotility in patients with hEDS. Methods This is a retrospective study of hEDS patients conducted at the Cleveland Clinic's Center for Personalized Genetic Healthcare between January 2007 and December 2017. Demographics, GI motility testing, endoscopic, and imaging data were extracted from the patients' charts. Results A total of 218 patients with hEDS were identified. Among them, 136 (62.3%) patients had at least one GI symptom at the time of EDS diagnosis. Motility testing was performed and reported in 42 (19.2%) patients. Out of them, five (11.9%) had esophageal dysmotility, 18 (42.8%) had gastroparesis, five (11.9%) had small bowel/colon altered transit time, and four (9.5%) had global dysmotility. In univariable analysis, patients with postural orthostatic tachycardia syndrome (POTS) [odds ratio (OR): 8.88, 95% CI: 3.69-24.9, p<0.0001], fibromyalgia (OR: 4.43, 95% CI: 2.04-10.1, p=0.0002), history of irritable bowel syndrome (OR: 5.01, 95% CI: 2.31-11.2, p<0.0001), and gastroesophageal reflux disease (OR: 3.33, 95% CI: 1.55-7.44, p=0.002) were more likely to be diagnosed with GI dysmotility. On multivariable analysis, only POTS (OR: 5.74, 95% CI: 2.25-16.7, p=0.0005) was significantly associated with an increased likelihood of GI dysmotility. Conclusions This study suggests that GI symptoms are relatively common among patients with hEDS. Of the patients tested for dysmotility, 76.2% were found to have some form of dysmotility. POTS was found to be an independent predictive factor for GI dysmotility.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The prevalence of POTS in patients with hEDS/HSD was 21.9% (95% CI 5.2-59.1, three studies).
“The prevalence of Postural Orthostatic Tachycardia Syndrome (POTS) in patients with hEDS/HSD was 21.9% (95% CI 5.2–59.1, three studies [10, 23, 25]), with considerable heterogeneity in the analysis (I 2 = 99.5, p = 0.0001) (Figure S45).”
From Meta-Analysis: Chronic Gastrointestinal Symptoms and Comorbidities in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders (2026) · cites this paper as [25]
The Results (Table 1; page not available) report POTS in 87 of 218 patients with hEDS (39.9%), so this paper provides a relevant study-level observation. It does not report the cited three-study pooled prevalence of 21.9%, its 95% confidence interval, or an HSD population. (LLM, conf=0.88)
Experimental — accuracy not yet measuredNutritional compromises may require invasive interventions such as enteral and parenteral nutrition.
“Nutritional compromises may require invasive interventions [25], such as enteral and parenteral nutrition, resulting in increased healthcare utilization and significantly impacting the quality of life for patients with hEDS/HSD [21, 27, 29].”
From Meta-Analysis: Chronic Gastrointestinal Symptoms and Comorbidities in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders (2026) · cites this paper as [25]
Orthostatic intolerance was prevalent in 35.9% (95% CI 26.6-46.4, seven studies) of patients with hEDS/HSD.
“Finally, we found that orthostatic intolerance was prevalent in 35.9% (95% CI 26.6–46.4, seven studies [10, 22, 23, 24, 25, 26, 28]) of patients with hEDS/HSD, with considerable heterogeneity in the analysis (I 2 = 96.4, p = 0.0001) (Figure S44).”
From Meta-Analysis: Chronic Gastrointestinal Symptoms and Comorbidities in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders (2026) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A note on quantifying follow-up in studies of failure time
SCHEMPER, M., & Smith, T. L. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(96)00075-x · Cited by 2,592 · cited 1× · see citing works
“The median follow-up time was calculated using the reverse Kaplan-Meier method [16].”
MethodThe 2017 international classification of the Ehlers–Danlos syndromes
Malfait, F., Francomano, C., Byers, P., Belmont, J., Berglund, B., Black, J., Bloom, L., Bowen, J. M., Brady, A. F., Burrows, N. P., et al. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31552 · Cited by 1,936 · cited 2× · see citing works
“A thorough review of the electronic medical records was performed for all patients, and the data extracted was used to diagnose hEDS based on the new 2017 international criteria for hEDS [4].”
MethodArticular mobility in an African population.
Beighton, P., Solomon, L., & Soskolne, C. L. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.413 · Cited by 1,727 · cited 1× · see citing works
“The 2017 international EDS classification was used to diagnose hEDS in all of our patients; it takes into account the Beighton score as well as other factors necessary to diagnose hEDS [17-19].”
MethodIdiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548 · see citing works
Connective tissue and its heritable disorders : molecular, genetic, and medical aspects
Royce, P. M., & Steinmann, B. (1993) · Cited by 440 · see citing works
The Ehlers–Danlos syndrome, a disorder with many faces
De Paepe, A., & Malfait, F. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01858.x · Cited by 379 · cited 1× · see citing works
“The new international EDS classification published in 2017 defines 13 subtypes of EDS, with hypermobile EDS (hEDS) being the most common subtype [2-4].”
MethodSteinmann, B., Royce, P. M., & Superti‐Furga, A. (2002) · Connective Tissue and Its Heritable Disorders · doi:10.1002/0471221929.ch9 · Cited by 358 · see citing works
Joint hypermobility syndrome in childhood. A not so benign multisystem disorder?
Adib, N., Davies, K., Grahame, R., Woo, P., & Murray, K. J. (2005) · Rheumatology · doi:10.1093/rheumatology/keh557 · Cited by 356 · cited 1× · see citing works
“A systematic review of GI surgeries and related complications in EDS suggests that surgery in patients with EDS is associated with a high risk of complications, which is why preoperative indications should be carefully considered [25].”
BackgroundJuul-Kristensen, B., Rogind, H., Jensen, D. V., & Remvig, L. (2007) · Rheumatology · doi:10.1093/rheumatology/kem290 · Cited by 299 · see citing works
Ehlers-Danlos syndromes and Marfan syndrome
Callewaert, B., Malfait, F., Loeys, B., & De Paepe, A. (2008) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.12.005 · Cited by 257 · see citing works
Bleeding and bruising in patients with Ehlers–Danlos syndrome and other collagen vascular disorders
Paepe, A. D., & Malfait, F. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05220.x · Cited by 239 · cited 1× · see citing works
“The inherent dysfunctional collagen synthesis in EDS might affect the structural integrity of supportive structures such as ligaments, blood vessels, and internal organs and can theoretically increase the risk of postoperative complications [26,27].”
BackgroundCastori, M., Camerota, F., Celletti, C., Danese, C., Santilli, V., Saraceni, V. M., & Grammatico, P. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33231 · Cited by 228 · see citing works
Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic
Nelson, A. D., Mouchli, M. A., Valentin, N., Deyle, D., Pichurin, P., Acosta, A., & Camilleri, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12665 · Cited by 182 · cited 4× · see citing works
“Studies have shown an increased prevalence of irritable bowel syndrome (IBS) in these patients when compared to age-matched controls [7].”
BackgroundResultInfluentialzarate, N., farmer, A. D., grahame, R., mohammed, S. D., knowles, C. H., scott, S. M., & aziz, Q. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01421.x · Cited by 178 · cited 2× · see citing works
“A few theories that have been put forward as possible mechanisms behind the intestinal dysmotility in EDS and those include autonomic neuropathy, mixed enteric neuro-myopathy, and alterations in the composition of the extracellular matrix in which the other components of the gut wall are embedded [11].”
BackgroundGastrointestinal involvement in the Ehlers–Danlos syndromes
Fikree, A., Chelimsky, G., Collins, H., Kovacic, K., & Aziz, Q. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31546 · Cited by 159 · cited 1× · see citing works
“In our study, patients with severe GI dysmotility requiring TPN or surgery after exhausting available medical options were managed by a multidisciplinary management team involving a rheumatologist, gastroenterologist, nutritionist, autonomic neurologist, and a surgeon with experience in the treatment of GI dysmotility…”
BackgroundHakim, A. J. (2004) · Rheumatology · doi:10.1093/rheumatology/keh279 · Cited by 147 · see citing works
Fikree, A., Aktar, R., Grahame, R., Hakim, A. J., Morris, J. K., Knowles, C. H., & Aziz, Q. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12535 · Cited by 117 · cited 10× · see citing works
“78 (35.8) IBS, n (”
InfluentialFikree, A., Grahame, R., Aktar, R., Farmer, A. D., Hakim, A. J., Morris, J. K., Knowles, C. H., & Aziz, Q. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.01.014 · Cited by 104 · cited 1× · see citing works
“In addition, the hEDS subtype appears to have more symptoms of dyspepsia (postprandial fullness) and heartburn than other subtypes [8].”
BackgroundRare diseases social epidemiology: analysis of inequalities
Kole, A., & Faurisson, F. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-90-481-9485-8_14 · Cited by 102 · cited 1× · see citing works
“Interestingly, a recent survey by the European Organization for Rare Diseases (EURORDIS) has shown that among patients with 16 rare genetic disorders, those with EDS have the longest delay in the diagnosis, often requiring consultation of up to 20 medical specialists [5].”
BackgroundCastori, M., Morlino, S., Pascolini, G., Blundo, C., & Grammatico, P. (2015) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31431 · Cited by 98 · cited 1× · see citing works
“Nevertheless, it is crucial to avoid opiates in these patients, and they should be provided with supplemental nutritional support [21,22].”
BackgroundMohammed, S. D., Lunniss, P. J., Zarate, N., Farmer, A. D., Grahame, R., Aziz, Q., & Scott, S. M. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01562.x · Cited by 70 · see citing works
Manning, J. A., Korda, A., Benness, C., & Solomon, M. J. (2003) · International Urogynecology Journal · doi:10.1007/s00192-002-1025-0 · Cited by 63 · see citing works
Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R., & Bharucha, A. E. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12480 · Cited by 63 · cited 1× · see citing works
“A large cohort study of 163 patients with POTS was evaluated, and 55 (34%) were found to have a normal gastric emptying time, 30 (18%) had a delayed or slowed gastric emptying time, and 78 (48%) were found to have rapid gastric emptying, suggesting that hEDS, autonomic symptoms, and GI symptoms are indeed linked, thou…”
BackgroundQuality of life in the classic and hypermobility types of Elhers‐Danlos syndrome
Castori, M., Camerota, F., Celletti, C., Grammatico, P., & Padua, L. (2009) · Annals of Neurology · doi:10.1002/ana.21934 · Cited by 46 · see citing works
Vounotrypidis, P., Efremidou, E., Zezos, P., Pitiakoudis, M., Maltezos, E., Lyratzopoulos, N., & Kouklakis, G. (2009) · Gastroenterology Research and Practice · doi:10.1155/2009/924138 · Cited by 44 · see citing works
The Ehlers-Danlos Specter Revisited
Cikrit, D. F., Glover, J., Dalsing, M. C., & Silver, D. (2002) · Vascular and Endovascular Surgery · doi:10.1177/153857440203600309 · Cited by 34 · cited 1× · see citing works
“The inherent dysfunctional collagen synthesis in EDS might affect the structural integrity of supportive structures such as ligaments, blood vessels, and internal organs and can theoretically increase the risk of postoperative complications [26,27].”
BackgroundMenys, A., Keszthelyi, D., Fitzke, H., Fikree, A., Atkinson, D., Aziz, Q., & Taylor, S. A. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13090 · Cited by 26 · cited 1× · see citing works
“GI dysmotility has also been reported in patients affected by hEDS [7,11,15].”
BackgroundPepin, M. G. (2009) · Journal of Genetic Counseling · doi:10.1007/s10897-009-9226-z · Cited by 10 · cited 1× · see citing works
“Nevertheless, it is crucial to avoid opiates in these patients, and they should be provided with supplemental nutritional support [21,22].”
BackgroundIndications et résultats de la transplantation intestinale chez l’adulte
Joly, F., & Panis, Y. H. (2012) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)31834-5 · Cited by 2 · see citing works
Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997
Beighton, P., Paepe, A. D., Steinmann, B., Tsipouras, P., & Wenstrup, R. J. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980428)77:1
Flagged first, then by citations
Research works printed but not linked: 1
- [23]Indications and results of intestinal transplantation in adults. (Article in French) Bull Acad Natl Med Joly F Panis Y 393 404 196 2012 23420959
Cited by
Sorted by citations
Mathias, C. J., Owens, A., Iodice, V., & Hakim, A. (2021) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31951 · Cited by 65 · see citing works
“In addition, PoTS is increasingly recognized as being associated with gastroparesis and functional gastrointestinal disorders (FGID) (Alomari et al., 2020; Mehr, Barbul, & Shibao, 2018; Tu, Abell, Raj, & Mar, 2020).”
BackgroundThwaites, P. A., Gibson, P. R., & Burgell, R. E. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15927 · Cited by 59 · see citing works
Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
Kornum, D. S., Terkelsen, A. J., Bertoli, D., Klinge, M. W., Høyer, K. L., Kufaishi, H., Borghammer, P., Drewes, A. M., Brock, C., & Krogh, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071392 · Cited by 51 · see citing works
“Normal lung and liver function are also a prerequisite.”
BackgroundSharp, H. E. C., Critchley, H. D., & Eccles, J. A. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.805 · Cited by 32 · see citing works
Long‐Term POTS Outcomes Survey: Diagnosis, Therapy, and Clinical Outcomes
Boris, J. R., Shadiack, E., McCormick, E. M., MacMullen, L. E., George‐Sankoh, I., & Falk, M. J. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033485 · Cited by 33 · see citing works
The biopsychosocial impact of hypermobility spectrum disorders in adults: a scoping review
Clark, N., Johnson, M., Rangan, A., Kottam, L., & Swainston, K. (2023) · Rheumatology International · doi:10.1007/s00296-023-05298-2 · Cited by 33 · see citing works
“The other two studies reported a slightly higher prevalence of ADHD in EDS and hEDS samples, 7% [9] and 11% [17] respectively.”
BackgroundMethodInfluentialBrooks, R. S., Grady, J., Lowder, T. W., & Blitshteyn, S. (2021) · Rheumatology · doi:10.1093/rheumatology/keaa926 · Cited by 28 · see citing works
Aziz, Q., Harris, L. A., Goodman, B. P., Simrén, M., & Shin, A. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2025.02.015 · Cited by 27 · see citing works
Lam, C., Amarasinghe, G., Zarate-Lopez, N., Fikree, A., Byrne, P., Kiani-Alikhan, S., Gabe, S., & Paine, P. (2023) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102088 · Cited by 23 · see citing works
Suresh, H., Zhou, J., & Ho, V. (2021) · Nutrients · doi:10.3390/nu13124298 · Cited by 22 · see citing works
Teran-Wodzinski, P. C., & Kumar, A. (2023) · Rheumatology International · doi:10.1007/s00296-023-05378-3 · Cited by 20 · see citing works
“Another important finding is that approximately 40% of participants reported pelvic floor dysfunction and cardiovascular problems, consistent with previous reports in the literature [50, 51].”
Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome
Spiegel, B. M. R. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002066 · Cited by 19 · see citing works
Schubart, J. R., Schaefer, É., Knight, D. R. T., Mills, S. E., & Francomano, C. A. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1365712 · Cited by 15 · see citing works
Wu, W. K. K., & Ho, V. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1379646 · Cited by 14 · see citing works
Recent Advances in the Management of Severe Gastrointestinal Dysmotility
Vasant, D. H., & Lal, S. (2021) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s249877 · Cited by 12 · see citing works
“…orthostatic tachycardia syndrome and segmental dysmotility affecting different parts of the gastrointestinal tract have been demonstrated, 34,35 there is currently no evidence for any specific treatment approaches, or evidence to suggest a greater degree of small bowel dysmotility in this…”
BackgroundChoudhary, A., Fikree, A., & Aziz, Q. (2021) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31938 · Cited by 12 · see citing works
Zhou, W., Zikos, T. A., Halawi, H., Sheth, V. R., Gurland, B., Nguyen, L. A. B., & Neshatian, L. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02572-8 · Cited by 9 · see citing works
“Evaluation of pelvic floor disorders using testing such as high resolution anorectal manometry (HR-ARM) and defecography have confirmed the presence of functional pathologies such as dyssynergic defecation and structural pathologies such as rectocele, and excessive perinium descent in HSD/hEDS patients [3].”
BackgroundGastrointestinal medication burden among persons with the Ehlers‐Danlos syndromes
Dhingra, R., Bascom, R., Thompson, E., Francomano, C. A., & Schubart, J. R. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14077 · Cited by 7 · see citing works
Sweerts, K. W. E., Mujagic, Z., Keszthelyi, D., & Conchillo, J. M. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18471 · Cited by 6 · see citing works
Anderson, L. K., & Lane, K. R. (2023) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000900 · Cited by 6 · see citing works
“, 2015); gastrointestinal symptoms including gut dysmotility, abdominal pain, gastroesophageal reflux disease, diarrhea, nausea, and constipation (Alomari et al., 2020; Bénistan & Martinez, 2019; De Wandele et al., 2014; Murray et al., 2013; Puledda et al., 2015; Scheper et al., 2016); skin and mucocutaneous symptoms…”
BackgroundInfluentialSantucci, N. R., Corsiglia, J., El‐Chammas, K. I., Shumeiko, O., Liu, C., & Kaul, A. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14701 · Cited by 6 · see citing works
“34,35 Neurologic and hypermobility spectrum disorders have been previously reported to occur in association with gastroparesis, 1,36–38 but we did not find a significant association of these conditions with delayed gastric emptying in our study.”
BackgroundPractical management strategies for benign hypermobility syndromes
Minhas, D. (2021) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000798 · Cited by 5 · see citing works
Kozyra, M., Kostyun, R. O., & Strecker, S. E. (2024) · Medicine · doi:10.1097/md.0000000000039212 · Cited by 4 · see citing works
“[12] 13–15] Misdiagnosis of these disorders is common, with up to 56% of patients being misdiagnosed initially, and 70% of patients receiving inappropriate treatment.”
BackgroundChoudhary, A., Makwana, K., Nee, J., & Aziz, Q. (2025) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003315 · Cited by 3 · see citing works
Dervin, H., Zárate-López, N., Sweis, R., Mensah, A., Fragkos, K. C., Brugaletta, C., Raeburn, A. J., & Emmanuel, A. V. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14570 · Cited by 3 · see citing works
Mathena, S. A., Allen, R. M., Laukaitis, C. M., & Andrews, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1499582 · Cited by 2 · see citing works
Sweerts, K. W. E., Vork, L., Mujagic, Z., Conchillo, J. M., & Keszthelyi, D. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09206-5 · Cited by 2 · see citing works
Ahmed, A., Paudel, B., & Sharma, A. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09958-8 · Cited by 2 · see citing works
Laserna, A., Nishtar, M., Vidovich, C., & Borovčanin, Ž. (2021) · Cureus · doi:10.7759/cureus.19311 · Cited by 2 · see citing works
“One retrospective study found that both EDS III and POTS are independent risk factors for gastrointestinal (GI) symptoms, including GI dysmotility and gastroesophageal reflux disease [15].”
Hypoglycemia Associated With Hypermobile Ehlers-Danlos Syndrome
Saeed, H., Sheehan, A. L., & Patti, M. (2024) · JCEM Case Reports · doi:10.1210/jcemcr/luae205 · Cited by 2 · see citing works
“Gastrointestinal manifestations include both structural (hernias, rectoceles, prolapse) and functional (dysmotility) abnormalities [13].”
BackgroundHow to feed patients with small intestinal dysmotility
Conley, T. E., Creed, E., & Lal, S. (2025) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001139 · Cited by 2 · see citing works
A young woman with fever and polyserositis caused by familial Mediterranean fever
Richard, K., Glazer, S., Demirkaya, E., & Karp, N. (2023) · Canadian Medical Association Journal · doi:10.1503/cmaj.220789 · Cited by 2 · see citing works
Shirvani, A., Shirvani, P., Jonah, U., Moore, B. E., & Holick, M. F. (2025) · Biomedicines · doi:10.3390/biomedicines13020469 · Cited by 1 · see citing works
“The absence of definitive molecular diagnostic tools continues to place patients at risk for inappropriate diagnosis of conditions like Munchausen Syndrome by Proxy, potentially leading to devastating consequences for families.”
Kulin, D., Holtmann, G., Fairlie, T., Staller, K., Nurko, S., Keefer, L., Drossman, D. A., Jones, M. P., Aziz, Q., & Shah, A. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70856
La 'scrittura di frontiera': autobiografia e altro ne "Il gioco dei regni" di Clara Sereni
Greatti, S. (2009) · Studi Novecenteschi
Suresh, H., Zhou, J., & Ho, V. (2022) · Nutrients · doi:10.3390/nu14091848
“It may be that the patients with gastroparesis and slow-transit constipation have a more generalised dysmotility, and in fact, we might expect this from conditions such as Ehlers–Danlos syndrome [4] which are affected systemically rather than locally as might be the case, for example, in post-surgical gastroparesis.”
BackgroundSantucci, N. R., & Kaul, A. (2022) · Springer eBooks · doi:10.1007/978-3-031-15229-0_24
Fièvre et polysérite causées par la fièvre méditerranéenne familiale chez une jeune femme
Richard, K., Glazer, S., Demirkaya, E., & Karp, N. (2023) · Canadian Medical Association Journal · doi:10.1503/cmaj.220789-f
Hotfiel, K., Rist, M., & Raithel, M. (2023) · Die Gastroenterologie · doi:10.1007/s11377-023-00703-5
Gastroparesis in a patient with benign joint hypermobility syndrome
Malakar, S., Mathur, A., Kolhatkar, S., & Ghoshal, U. C. (2023) · Indian Journal of Gastroenterology · doi:10.1007/s12664-023-01451-8
Was ist gesichert bei Reizdarmsyndrom und Nahrungsmittelunverträglichkeiten?
Raithel, M., Hotfiel, A.-K., Rist, M., & Konturek, P. C. (2023) · Gastro-News · doi:10.1007/s15036-023-3331-y
“Bereits Jarisch et al. wiesen im Jahr 2004 darauf hin, dass bis zu 58 % der untersuchten RDS-Patienten Beschwerden auf histamin-beziehungsweise biogene aminehaltige Lebensmittel erhielten [8, 15, 16, 29, 30, 31].”
BackgroundButt, M. F., & Aziz, Q. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95082-4.00088-8
Singh, J., Shruti, V., & Alka, A. (2024) · Global Journal of Infectious Diseases and Clinical Research · doi:10.17352/2455-5363.000060
Chambers, P. W. (2025) · Qeios · doi:10.32388/r0na31
Chambers, P. W. (2025) · Qeios · doi:10.32388/r0na31.2
Chambers, P. W. (2025) · Qeios · doi:10.32388/r0na31.3
Oelerich, K., Bains, K., Minchenberg, S. B., Deshpande, V., Iturrino-Moreda, J., & Kulkarni, S. (2025) · ACG Case Reports Journal · doi:10.14309/crj.0000000000001823
Structural Gastrointestinal and Urogenital Dysfunction and hEDS/HSD
DePace, N. L., Soloway, S., Yayac, M. F., & Colombo, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-88769-7_12
Gereizter Darm durch Nahrungsmittelunverträglichkeit?
Hotfiel, K., Sarsour, A., & Raithel, M. (2025) · Gastro-News · doi:10.1007/s15036-025-3951-5
“Bei diesem Ansatz bleibt jedoch unklar, ob dies am Histamin selbst im Lebensmittel lag, oder ob Bestandteile des Lebensmittels eine allergische Reaktion mit Histaminfreisetzung auslösten [4, 11, 19, 25, 27].”
InfluentialLee, M. E., Harris, L. A., & Katz, P. O. (2026) · Foregut The Journal of the American Foregut Society · doi:10.1177/26345161261465536
Wu, M., Wang, X., Wang, L., Xiang, M. Y., & Xu, L. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1935940
Mugica, A. B. (2026) · Saber Estratégico Internacional · doi:10.70577/s.e.v4i4.146
- Authors
- Alomari, M., Hitawala, A., Chadalavada, P., Covut, F., Al Momani, L., Khazaaleh, S., Gosai, F., Al Ashi, S., Abushahin, A., & Schneider, A.
- Affiliations
- East Tennessee State University (US)
- Corresponding author
- Schneider, Alison
- Venue
- Cureus
- Published
- 2020-04-29
- Volume
- 12
- Issue
- 4
- Pages
- e7881-e7881
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC7255528
- OpenAlex
- W3022656911
- Cited by
- 53
- References
- 31
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- hypermobile Ehlers-Danlos syndrome, gastrointestinal motility disorders, postural orthostatic tachycardia syndrome, gastroparesis, esophageal motility disorders, small intestinal transit, irritable bowel syndrome, fibromyalgia, gastroesophageal reflux disease, risk factors, prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
