The DOI matches its Crossref record; 17 of the 20 references it cites were found in a registry or an index.
Comparative Anatomical Study Between the Human and Swine Liver and Its Importance in Xenotransplantation
Open accessAbstract
The liver is a multifunctional organ; due to its functional and structural complexity, there are many factors that may lead it to function inadequately, a state called liver failure. Transplantation is the only appropriate therapy for patients in cases of liver failure. However, there are many limitations to this treatment, and the scientific community has considered methods based on pigs because of their unique structural and cellular compatibility with humans. In this review, we conducted an anatomic comparative study of the liver's parenchyma and vascular network between humans and pigs to extract useful information for xenotransplantation and autologous cell or organ generation in pigs. We reviewed articles from 2007 to 2019 and used the databases of Scopus, PubMed and Google Scholar. We concluded that, despite the difference concerning the shape of the human and pig livers, the number of segments and the bile and vascular system are similar, making the pig liver useful in experimental surgery for xenotransplantation.
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“The portal veins of human and porcine liver exhibit a few differences. In pigs, the portal vein divides into right and left branches at the hilum, while in humans, this division occurs before entering the liver parenchyma.”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [47]
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Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923
All about portal vein: a pictorial display to anatomy, variants and physiopathology
Carneiro, C. S., Brito, J. B., Bilreiro, C., Barros, M. H., Bahia, C., Santiago, I., & Caseiro‐Alves, F. (2019) · Insights into Imaging · doi:10.1186/s13244-019-0716-8 · Cited by 156
Coagulopathy in liver disease: a balancing act
Kujovich, J. L. (2015) · Hematology · doi:10.1182/asheducation-2015.1.243 · Cited by 155
Anatomy of rodent and human livers: What are the differences?
Kruepunga, N., Hakvoort, T. B. M., Hikspoors, J. P. J. M., Köhler, S. E., & Lamers, W. H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.05.019 · Cited by 79
Current concepts in acute liver failure
Rovegno, M., Vera, M., Ruiz, A., & Benítez, C. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2019.04.008 · Cited by 75
Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic
Cooper, D. K. C., Dou, K., Tao, K., Yang, Z.-X., Tector, A. J., & Ekser, B. (2016) · Transplantation · doi:10.1097/tp.0000000000001319 · Cited by 69
Campbell, I. T. (2006) · Anaesthesia & intensive care medicine · doi:10.1383/anes.2006.7.2.51 · Cited by 50
Current status of pig liver xenotransplantation
Ekser, B., Markmann, J. F., & Tector, A. J. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.06.083 · Cited by 43
Intraoperative Events in Liver Transplantation Using Donation After Circulatory Death Donors
Chadha, R., Croome, K. P., Aniskevich, S., Pai, S., Nguyen, J. H., Burns, J. M., Perry, D. K., & Taner, C. B. (2019) · Liver Transplantation · doi:10.1002/lt.25643 · Cited by 35
Regulatory barriers to xenotransplantation
Goerlich, C. E., Chan, J. L., & Mohiuddin, M. M. (2019) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000678 · Cited by 25
Research works printed but not linked: 3
- Mani I, Dourakis SP. Complications and treatment of acute liver failure: current aspects. Arch Hellen Med. 2019, 37:452-463.
- Mihail SG. Comparative Anatomy of Domestic Mammals. Kiriakidis Brothers Press, Thessaloniki; 2010.
- Kuipers EJ. Encyclopedia of Gastroenterology, 2nd edition. Academic Press, London; 2019.
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“A distinctive feature of the biliary drainage of the pig liver is that the drainage of segment I is accomplished through the right he-patic duct in pigs, while in humans, it is drained through left hepatic duct [47].”
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Saruwatari, M., Jawed, K. J., Ali, K. M., Ning, B., Naik, S., Nam, S. H., Schnermann, M. J., Sandler, A. D., & Cha, J. (2023) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23661 · Cited by 3
Barnett, D. R., Bhattacharjya, R., & Bhattacharjya, S. (2026) · Laboratory Animals · doi:10.1177/00236772251397586 · Cited by 2
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Lucci, A. E. (2023) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12241 · Cited by 1
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Metadata
- Authors
- Ntonas, A., Katsourakis, A., Galanis, N., Filo, E., & Noussios, G.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Ntonas, Athanasios
- Venue
- Cureus
- Published
- 2020-07-27
- Volume
- 12
- Issue
- 7
- Pages
- e9411-e9411
- ISSN
- 2168-8184 (ISSN-L)
- PMC
- PMC7449635
- OpenAlex
- W3044817777
- Cited by
- 28
- References
- 20
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 1 · 2021: 3
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Cureus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Anatomy › Comparative Animal Anatomy Studies
- Keywords
- liver anatomy, xenotransplantation, liver failure, liver transplantation, liver parenchyma, bile ducts, liver segmentation, porcine liver
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