Prevalence and genotypic distribution of hepatitis GB‐C/HG and TT viruses in blood donors, mentally retarded children and four groups of patients in eastern Anatolia, Turkey
Open accessAbstract
We investigated the prevalence and genotypic distribution of GB virus-C/hepatitis G virus (GBV-C/HGV) and TT virus (TTV) in blood donors, mentally retarded children and four groups of patients living in Eastern Anatolia, Turkey. The prevalence and genetic analysis of TTV were determined by using the primers of the UTR and ORF1 regions of TTV, respectively. Reverse transcription nested (RT-n)-PCR was used to amplify 5' UTR of GBV-C/HGV. Genotyping of HGV was carried out by PCR-based genotyping assay while RFLP was conducted to determine the genotypes of TTV. TTV DNA was detected in 118 of 410 sera tested, giving an overall prevalence of 28.7%; GBV-C/HGV-RNA was detected in only 17 cases, giving an overall prevalence of 4.1%. No significant differences were observed in the number of positive or negative tests for GBV-C/HGV and TTV according to duration of illness or mean duration of institutionalization in any of the groups studied. Although all samples from the study population belonged to genotypes 1 and 4, the most common TTV genotype is G2. In conclusion, our results indicate a low endemicity of GBV-C/HGV and TTV infection in Eastern Anatolia, Turkey. The presence of G2 strains reveals the limited genetic diversity of the GBV-C/HGV circulating in Turkey. We suggest that TTV infection of genotypes 1 and 4 is prevalent in the same region.
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In the largest study to date, prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients were approximately 5 and 11 times the overall estimated population rates for these infections.
“The largest study to date found prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients to be approximately 5 and 11 times the overall estimated population rates for these infections.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [401]
Across different continents, rates of hepatitis virus infection are markedly elevated in persons with SMI compared to the general population.
“Across different continents, markedly elevated rates of hepatitis virus infection have been reported in persons with SMI compared to the general population (364,396-403).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [401]
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- Authors
- Kalkan, A., Ozdarendeli, A., Bulut, Y., Saral, Y., Ozden, M., Keleştimur, N., & Toraman, Z. A.
- Affiliations
- Fırat University (TR)
- Department of Microbiology, Faculty of Medicine, Firat University, Turkey
- Department of Immunology, Faculty of Medicine, Firat University, Turkey
- Venue
- Japanese Journal of Infectious Diseases
- Publisher
- Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis
- Published
- 2005-08-29
- Volume
- 58
- Issue
- 4
- Pages
- 222-227
- ISSN
- 1344-6304 (ISSN-L)
- 1884-2836
- OpenAlex
- W2165781551
- Cited by
- 30
- References
- 32
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- dx.doi.org
- Locations
- Japanese Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- DSpace - FIRAT (Fırat University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Keywords
- hepatitis G virus, TT virus, prevalence, genotyping, blood donors, mentally retarded children, institutionalized children, endemicity, genetic diversity, Eastern Anatolia
- MeSH terms
- Adolescent, Adult, Aged, Blood Donors, DNA, Viral, Female, Genotype, Hepatitis, Viral, Human, Hospitals, Psychiatric, Humans, Leprosy, Male, Intellectual Disability, Middle Aged, Risk Factors, RNA, Viral, Schizophrenia, Turkey, Prevalence, Polymerase Chain Reaction, Circoviridae Infections, Flaviviridae Infections, Hepatitis B, Chronic, Hepatitis C, Chronic, Torque teno virus, GB virus C
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