Physical illness and schizophrenia: a review of the literature

Leucht, S.; Burkard, T.; Henderson, J.; Maj, M.; Sartorius, N.

doi:10.1111/j.1600-0447.2007.01095.x

Cited by 633Schizophrenia research and treatmentMental Health and PsychiatryMental Health Treatment and Access

Physical illness and schizophrenia: a review of the literature

Leucht, S., Burkard, T., Henderson, J., Maj, M., Sartorius, N.·2007·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2007.01095.x

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Abstract

Objective: The lifespan of people with schizophrenia is shortened compared to the general population. We reviewed the literature on comorbid physical diseases in schizophrenia to provide a basis for initiatives to fight this unacceptable situation. Method: We searched MEDLINE (1966 – May 2006) combining the MeSH term of schizophrenia with the 23 MeSH terms of general physical disease categories to identify relevant epidemiological studies. Results: A total of 44 202 abstracts were screened. People with schizophrenia have higher prevalences of HIV infection and hepatitis, osteoporosis, altered pain sensitivity, sexual dysfunction, obstetric complications, cardiovascular diseases, overweight, diabetes, dental problems, and polydipsia than the general population. Rheumatoid arthritis and cancer may occur less frequently than in the general population. Eighty‐six per cent of the studies came from industrialized countries limiting the generalizability of the findings. Conclusion: The increased frequency of physical diseases in schizophrenia might be on account of factors related to schizophrenia and its treatment, but undoubtedly also results from the unsatisfactory organization of health services, from the attitudes of medical doctors, and the social stigma ascribed to the schizophrenic patients.

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People with mental illness are less likely to receive appropriate medications, such as beta-blockers and statins, on discharge following myocardial infarction.
“They are also less likely to receive appropriate medications, such as b-blockers and statins, on discharge following myocardial infarction.119”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [119]
There is an extensive literature reporting an increased occurrence of obstetric complications among women who have schizophrenia.
“There is an extensive literature reporting an increased occurrence of obstetric complications among women who have schizophrenia (15).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [15]

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Authors: Leucht, S., Burkard, T., Henderson, J., Maj, M., & Sartorius, N.
Affiliations: TUM Klinikum (DE)
University of Naples Federico II (IT)
Corresponding author: Leucht, S.
ORCID: Leucht, S.
Henderson, J.
Maj, M.
Sartorius, N.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2007-10-04
Volume: 116
Issue: 5
Pages: 317-333
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.2007.01095.x
OpenAlex: W2158448796
Cited by: 633
References: 289
Citations by year: 2026: 5 · 2025: 14 · 2024: 25 · 2023: 22 · 2022: 24 · 2021: 28 · 2020: 28 · 2019: 42 · 2018: 32 · 2017: 36 · 2016: 47 · 2015: 44 · 2014: 51 · 2013: 49 · 2012: 41
FWCI: 4.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: schizophrenia, somatic comorbidity, physical illness, mortality, HIV infection, hepatitis, osteoporosis, pain sensitivity, sexual dysfunction, cardiovascular disease, diabetes mellitus, dental problems, polydipsia, rheumatoid arthritis, cancer, antipsychotic adverse effects, health care organization, stigma
MeSH terms: Cause of Death, Cross-Sectional Studies, Health Status Indicators, Humans, Schizophrenia, Comorbidity, Incidence

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Physical illness and schizophrenia: a review of the literature

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