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Phenolic Constituents of Anethum graveolens Seed Extracts: Chemical Profile and Antioxidant Effect Studies
Open accessAbstract
The Aim of the Research: Anethum graveolens (dill) is a common herb used in traditional Romanian cuisine, as well as in phytotherapy. Dill seeds have been reported to be rich in antioxidants. As interest in food additives of natural origin has increased in recent years, the purpose of this paper was to study the composition and antioxidant potential of Romanian dill seeds. Methodology: In this study, the total phenolics contents, the phenolic profile, and the antioxidant properties of the methanolic and hydromethanolic extracts of Romanian dill seeds were investigated. Folin-Ciocalteu assay, DPPH spectrophotometrically method and reverse-phase high-performance liquid chromatography RP-HPLC, respectively were applied. Results: The highest content of total phenolics was found in acidified methanol samples (46.5 - 46.8 mg GAE/g dry seeds). RP-HPLC analysis highlights important content of quercetin, kaempferol, caffeic acid, sinapic acid, gallic acid, vanillic acid, (±) - catechin and umbelliferone. Antioxidant activity, measured via DPPH free radical scavenging ability, showed very high values (93.5 - 95.6% for the crude extracts and 67.5 - 93.2% for extracts at a concentration of 0.25 mg/mL). Methanolic extract exhibited the best IC50 value (88.7 ± 0.01 μg/mL). Conclusion: All experiments proved the antioxidant activity of dill seed extracts.
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Hadi, N., Drioiche, A., Bouchra, E. M., Baammi, S., Abdelaziz Shahat, A., Tagnaout, I., Radi, M., Remok, F., Bouzoubaa, A., & Zair, T. (2024) · Pharmaceuticals · doi:10.3390/ph17070862 · Cited by 30
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Badea, G. E., Stănăşel, O., Bassyouni, M. I., Toderaș, M., Petrehele, A. I. G., & Ionaș, C. D. (2025) · Results in Chemistry · doi:10.1016/j.rechem.2025.102378 · Cited by 6
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Metadata
- Authors
- Bota, S. R., Stanasel, O. D., Blidar, C. F., & Serban, G.
- Affiliations
- University of Oradea (RO)
- Venue
- Journal of Pharmaceutical Research International
- Publisher
- Sciencedomain International
- Published
- 2021-12-11
- Volume
- 33
- Issue
- 54B
- Pages
- 168-179
- ISSN
- 2231-2919 (ISSN-L)
- 2456-9119
- OpenAlex
- W4200164928
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Pharmaceutical Research International (publishedVersion, cc-by)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- dill, dill seeds, phenolic compounds, antioxidant activity, total phenolic content, quercetin, kaempferol, sinapic acid, catechins, umbelliferone, DPPH radical scavenging, methanol extract
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