Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood
Open accessAbstract
OBJECTIVE: : We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. METHODS: : A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. RESULTS: : The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didnt find any correlation between the umbilical cord blood BDNF levels and BDI scores. CONCLUSION: : The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.
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Prenatal factors such as maternal depression may impact BDNF levels in the cord blood of neonates such that BDNF concentrations were significantly lower compared with healthy control subjects.
“Like CRH, GABA, and NR3C1, prenatal factors such as maternal depression may impact BDNF levels in the cord blood of neonates such that BDNF concentrations were significantly lower compared with healthy control subjects (Sonmez et al., 2019).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Sonmez et al., 2019
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- Authors
- Sonmez, E. O., Uguz, F., Sahingoz, M., Sonmez, G., Kaya, N., Camkurt, M. A., Gokmen, Z., Basaran, M., Gezginc, K., Erdem, S. S., Dulger, H. H., & Tasyurek, E.
- Affiliations
- Department of Psychiatry, Dr. Ekrem Tok Mental Health and Disease Hospital
- Department of Psychiatry
- Department of Pediatrics, Çukurova University
- Department of Behavioral Health (US)
- Department of Neonatology
- Department of Obstetrics and Gynecology
- Konya Eğitim ve Araştırma Hastanesi (TR)
- Necmettin Erbakan University (TR)
- Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University
- Venue
- Clinical Psychopharmacology and Neuroscience
- Published
- 2019-05-31
- Volume
- 17
- Issue
- 2
- Pages
- 308-313
- ISSN
- 1738-1088 (ISSN-L)
- 2093-4327
- PMC
- PMC6478092
- OpenAlex
- W2921488837
- Cited by
- 23
- References
- 36
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Clinical Psychopharmacology and Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- maternal depression, brain-derived neurotrophic factor, umbilical cord blood, pregnancy, fetal brain development, antenatal depression, cesarean section
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