Horvath, Steve

LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

Della Valle, F., Reddy, P., Yamamoto, M., Liu, P., Saera-Vila, A., Bensaddek, D., Zhang, H., Prieto Martinez, J., Abassi, L., Celii, M., et al. (2022) · Science Translational Medicine

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 127

Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons

Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., et al. (2021) · Science

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 121

The organization of the transcriptional network in specific neuronal classes

Winden, K. D., Oldham, M. C., Mirnics, K., Ebert, P. J., Swan, C. H., Levitt, P., Rubenstein, J. L., Horvath, S., & Geschwind, D. H. (2009) · Molecular Systems Biology

Bioinformatics and Genomic NetworksDevelopmental Biology and Gene Regulation

Cited by 112

Transposon-triggered innate immune response confers cancer resistance to the blind mole rat

Zhao, Y., Oreskovic, E., Zhang, Q., Lu, Q., Gilman, A., Lin, Y. S., He, J., Zheng, Z., Lu, J. Y., Lee, J., et al. (2021) · Nature Immunology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 99

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

Tian, Y., Voineagu, I., Paşca, S. P., Won, H., Chandran, V., Horvath, S., Dolmetsch, R. E., & Geschwind, D. H. (2014) · Genome Medicine

Genetics and Neurodevelopmental DisordersIon channel regulation and function

Cited by 93

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression

Kabacik, S., Horvath, S., Cohen, H., & Raj, K. (2018) · Aging

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 68

Increased epigenetic age in normal breast tissue from luminal breast cancer patients

Hofstatter, E. W., Horvath, S., Dalela, D., Gupta, P., Chagpar, A. B., Wali, V. B., Bossuyt, V., Storniolo, A. M., Hatzis, C., Patwardhan, G., et al. (2018) · Clinical Epigenetics

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 64

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Sturm, G., Cardenas, A., Bind, M.-A., Horvath, S., Wang, S., Wang, Y., Hägg, S., Hirano, M., & Picard, M. (2019) · Epigenetics

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 61

Synchrony and asynchrony between an epigenetic clock and developmental timing

Hoshino, A., Horvath, S., Sridhar, A., Chitsazan, A., & Reh, T. A. (2019) · Scientific Reports

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 55

Coffee Consumption Is Associated with DNA Methylation Levels of Human Blood

Chuang, Y.-H., Quach, A., Absher, D., Assimes, T., Horvath, S., & Ritz, B. (2017) · European Journal of Human Genetics

Epigenetics and DNA MethylationCoffee research and impacts

Cited by 40

Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers

Clement, J., Yan, Q., Agrawal, M., Coronado, R. E., Sturges, J. A., Horvath, M., Lu, A. T., Brooke, R. T., & Horvath, S. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 34

DNA repair‐deficient premature aging models display accelerated epigenetic age

Perez, K., Parras, A., Picó, S., Rechsteiner, C., Haghani, A., Brooke, R., Mrabti, C., Schoenfeldt, L., Horvath, S., & Ocampo, A. (2024) · Aging Cell

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 31

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Lu, Y., Krishnan, A., Brommer, B., Tian, X., Meer, M., Vera, D. L., Wang, C., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationRetinal Development and Disorders

Cited by 20

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Paine, P. T., Rechsteiner, C., Morandini, F., Desdín-Micó, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2024) · Frontiers in Aging

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 13

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Paine, P. T., Rechsteiner, C., Morandini, F., Desdin Mico, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2023) · Frontiers in Aging

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 13

Divergent age-related methylation patterns in long and short-lived mammals

Haghani, A., Wang, N., Lu, A. T., Mozhui, K., Mammalian Methylation Consortium, Raj, K., Yang, X. W., & Horvath, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 9