Horvath, Steve

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice.

Browder, K. C., Reddy, P., Yamamoto, M., Haghani, A., Guillen, I. G., Sahu, S., Wang, C., Luque, Y., Prieto, J., Shi, L., et al. (2022) · Nature Aging

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 253

Prenatal and early life influences on epigenetic age in children: A study of mother–offspring pairs from two cohort studies

Simpkin, A. J., Hemani, G., Suderman, M., Gaunt, T. R., Lyttleton, O., Mcardle, W. L., Ring, S. M., Sharp, G. C., Tilling, K., Horvath, S., et al. (2016) · Human Molecular Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 246

Biological age is increased by stress and restored upon recovery

Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T., Haghani, A., Gong, T., et al. (2023) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 246

Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells

Mason, M. J., Fan, G., Plath, K., Zhou, Q., & Horvath, S. (2009) · BMC Genomics

Pluripotent Stem Cells ResearchBioinformatics and Genomic Networks

Cited by 243

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 240

Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder

Boks, M. P., Mierlo, H. C. V., Rutten, B. P. F., Radstake, T. R. D. J., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, L. C., Vinkers, C. H., Broen, J. C. A., et al. (2015) · Psychoneuroendocrinology

Posttraumatic Stress Disorder ResearchTelomeres, Telomerase, and Senescence

Cited by 231

Metformin decelerates aging clock in male monkeys

Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Qiao, Y., et al. (2024) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 227

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. (2016) · eLife

Pluripotent Stem Cells ResearchGenetics, Aging, and Longevity in Model Organisms

Cited by 213

Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases

Lam, J. S., Yamashiro, J., Shintaku, I. P., Vessella, R. L., Jenkins, R. B., Horvath, S., Said, J. W., & Reiter, R. E. (2005) · Clinical Cancer Research

Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment

Cited by 211

The relationship between epigenetic age and the hallmarks of aging in human cells.

Kabacik, S., Lowe, D., Fransen, L., Leonard, M., Ang, S.-L., Whiteman, C., Corsi, S., Cohen, H., Felton, S., Bali, R., et al. (2022) · Nature Aging

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 207

A multi-tissue full lifespan epigenetic clock for mice

Thompson, M. J., Chwiałkowska, K., Rubbi, L., Lusis, A. J., Davis, R. C., Srivastava, A., Korstanje, R., Churchill, G. A., Horvath, S., & Pellegrini, M. (2018) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 203

The cerebellum ages slowly according to the epigenetic clock

Horvath, S., Mah, V., Lu, A. T., Woo, J. S., Choi, O.-W., Jasinska, A. J., Riancho, J. A., Tung, S., Coles, N. S., Braun, J., et al. (2015) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 191

Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study

Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry

Sleep and related disordersEpigenetics and DNA Methylation

Cited by 173

A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

Plaisier, C. L., Horvath, S., Huertas-Vazquez, A., Cruz-Bautista, I., Herrera, M. F., Tusie-Luna, T., Aguilar-Salinas, C., & Pajukanta, P. (2009) · PLoS Genetics

Genetic Associations and EpidemiologyLipid metabolism and disorders

Cited by 163

Network methods for describing sample relationships in genomic datasets: Application to Huntington’s disease

Oldham, M. C., Langfelder, P., & Horvath, S. (2012) · BMC Systems Biology

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 154

Using genetic markers to orient the edges in quantitative trait networks: The NEO software

Aten, J. E., Fuller, T. F., Lusis, A. J., & Horvath, S. (2008) · BMC Systems Biology

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 147

Epigenetic clock analyses of cellular senescence and ageing.

Lowe, D., Horvath, S., & Raj, K. (2016) · Oncotarget

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 147

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial

Bischoff-Ferrari, H. A., Gängler, S., Wieczorek, M., Belsky, D. W., Ryan, J., Kressig, R. W., Stähelin, H. B., Theiler, R., Dawson-Hughes, B., Rizzoli, R., et al. (2025) · Nature Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 140

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Corominas, R., Yang, X., Lin, G. N., Kang, S., Shen, Y., Ghamsari, L., Broly, M., Rodriguez, M., Tam, S., Wanamaker, S. A., et al. (2014) · Nature Communications

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 140

An epigenetic predictor of death captures multi-modal measures of brain health

Hillary, R. F., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A. M., Redmond, P., et al. (2021) · Molecular Psychiatry

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 139

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 134

Neuropathological and transcriptomic characteristics of the aged brain

Miller, J. A., Guillozet-Bongaarts, A., Gibbons, L. E., Postupna, N., Renz, A., Beller, A. E., Sunkin, S. M., Ng, L., Rose, S. E., Smith, K. A., et al. (2017) · eLife

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 134

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Sanz-Ros, J., Romero-García, N., Mas-Bargues, C., Monleón, D., Gordevicius, J., Brooke, R. T., Dromant, M., Díaz, A., Derevyanko, A., Guío-Carrión, A., et al. (2022) · Science Advances

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 131

DNA methylation networks underlying mammalian traits

Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., et al. (2023) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 128