Horvath, Steve

Functional organization of the transcriptome in human brain

Oldham, M. C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S., & Geschwind, D. H. (2008) · Nature Neuroscience

Gene expression and cancer classificationSingle-cell and spatial transcriptomics

Cited by 752

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. D. L. T., Huang, J., et al. (2016) · Nature

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 685

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

Horvath, S., Zhang, B., Carlson, M., Lu, K. V., Zhu, S., Felciano, R. M., Laurance, M. F., Zhao, W., Qi, S., Chen, Z., et al. (2006) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentBioinformatics and Genomic Networks

Cited by 641

Gene network interconnectedness and the generalized topological overlap measure

Yip, A. M., & Horvath, S. (2007) · BMC Bioinformatics

Bioinformatics and Genomic NetworksComplex Network Analysis Techniques

Cited by 633

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

Cloughesy, T. F., Yoshimoto, K., Nghiemphu, P., Brown, K., Dang, J., Zhu, S., Hsueh, T., Chen, Y., Wang, W., Youngkin, D., et al. (2008) · PLoS Medicine

Glioma Diagnosis and TreatmentPI3K/AKT/mTOR signaling in cancer

Cited by 593

Conservation and evolution of gene coexpression networks in human and chimpanzee brains

Oldham, M. C., Horvath, S., & Geschwind, D. H. (2006) · Proceedings of the National Academy of Sciences

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 566

HIV-1 infection accelerates age according to the epigenetic clock

Horvath, S., & Levine, A. J. (2015) · Journal of Infectious Diseases

HIV Research and TreatmentEpigenetics and DNA Methylation

Cited by 556

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

Miller, J. A., Horvath, S., & Geschwind, D. H. (2010) · Proceedings of the National Academy of Sciences

Bioinformatics and Genomic NetworksAlzheimer's disease research and treatments

Cited by 480

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 477

GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

McCrory, C., Fiorito, G., Hernandez, B., Polidoro, S., O’Halloran, A. M., Hever, A., Ni Cheallaigh, C., Lu, A. T., Horvath, S., Vineis, P., et al. (2021) · The Journals of Gerontology: Series A

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 464

Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight

Ghazalpour, A., Doss, S., Zhang, B., Wang, S., Plaisier, C., Castellanos, R., Brozell, A., Schadt, E. E., Drake, T. A., Lusis, A. J., et al. (2006) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Mapping and Diversity in Plants and Animals

Cited by 462

Comparison of co-expression measures: mutual information, correlation, and model based indices

Song, L., Langfelder, P., & Horvath, S. (2012) · BMC Bioinformatics

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 460

Understanding network concepts in modules

Dong, J., & Horvath, S. (2007) · BMC Systems Biology

Bioinformatics and Genomic NetworksComplex Network Analysis Techniques

Cited by 455

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

Levine, M. E., Lu, A. T., Bennett, D. A., & Horvath, S. (2015) · Aging

Dementia and Cognitive Impairment ResearchEpigenetics and DNA Methylation

Cited by 455

DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P.-C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., et al. (2019) · Aging

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 440

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice

Langfelder, P., Cantle, J. P., Chatzopoulou, D., Wang, N., Gao, F., Al-Ramahi, I., Lu, X.-H., Ramos, E. M., El-Zein, K., Zhao, Y., et al. (2016) · Nature Neuroscience

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 385

Validation of biomarkers of aging

Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 361

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

Guo, D., Prins, R. M., Dang, J., Kuga, D., Iwanami, A., Soto, H., Lin, K. Y., Huang, T. T., Akhavan, D., Hock, M. B., et al. (2009) · Science Signaling

Cancer, Lipids, and MetabolismGlioma Diagnosis and Treatment

Cited by 351

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Horvath, S., Pirazzini, C., Bacalini, M. G., Gentilini, D., Di Blasio, A. M., Delledonne, M., Mari, D., Arosio, B., Monti, D., Passarino, G., et al. (2015) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 316

When is hub gene selection better than standard meta-analysis?

Langfelder, P., Mischel, P. S., & Horvath, S. (2013) · PLoS ONE

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 313

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.

Sarkar, T. J., Quarta, M., Mukherjee, S., Colville, A., Paine, P., Doan, L., Tran, C. M., Chu, C. R., Horvath, S., Qi, L. S., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 308

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Shirasaki, D. I., Greiner, E. R., Al-Ramahi, I., Gray, M., Boontheung, P., Geschwind, D. H., Botas, J., Coppola, G., Horvath, S., Loo, J. A., et al. (2012) · Neuron

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 297

Genes and pathways underlying regional and cell type changes in Alzheimer’s disease

Miller, J. A., Woltjer, R. L., Goodenbour, J. M., Horvath, S., & Geschwind, D. H. (2013) · Genome Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 275

Making sense of the ageing methylome

Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 274