Chen, Zhijian J.

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 4,996

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell

interferon and immune responsesImmune Response and Inflammation

Cited by 3,329

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,333

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity

interferon and immune responsesImmunotherapy and Immune Responses

Cited by 2,182

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 2,125

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 1,927

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 1,872

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine

interferon and immune responsesImmune Response and Inflammation

Cited by 1,293

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F., & Chen, Z. J. (2019) · Nature

interferon and immune responsesAutophagy in Disease and Therapy

Cited by 1,269

Ubiquitin signalling in the NF-κB pathway

Chen, Z. J. (2005) · Nature Cell Biology

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 1,184

Structural basis of STING binding with and phosphorylation by TBK1

Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X.-C., & Chen, Z. J. (2019) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,095

cGAS in action: Expanding roles in immunity and inflammation

Ablasser, A., & Chen, Z. J. (2019) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 1,077

cGAS is essential for cellular senescence

Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 1,009

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell

interferon and immune responsesCell death mechanisms and regulation

Cited by 847

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Chen, J., & Chen, Z. J. (2018) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 692

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and Biomarkersinterferon and immune responses

Cited by 563

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 509

Regulation of NF-κB by ubiquitination

Chen, J., & Chen, Z. J. (2013) · Current Opinion in Immunology

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 258

Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

Liu, C., Qian, W., Qian, Y., Giltiay, N. V., Lu, Y., Swaidani, S., Misra, S., Deng, L., Chen, Z. J., & Li, X. (2009) · Science Signaling

NF-κB Signaling PathwaysPsoriasis: Treatment and Pathogenesis

Cited by 224

A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma

Bellail, A. C., Olson, J. J., Yang, X., Chen, Z. J., & Hao, C. (2012) · Cancer Discovery

Cell death mechanisms and regulationUbiquitin and proteasome pathways

Cited by 113