Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
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The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.
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GATA4 induces expression of TRAF3IP2, an E3 ubiquitin ligase for TRAF6.
“GATA4 induced the expression of TRAF3IP2, an E3 ubiquitin ligase for TRAF6 (51) (Fig. 4C)”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [51]
Act1 has E3 ubiquitin ligase activity.
“Act1 has E3 Ubiquitin ligase activity”
From The IL-17 Family of Cytokines in Health and Disease (2019) · cites this paper as Liu et al., 2009
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- Authors
- Liu, C., Qian, W., Qian, Y., Giltiay, N. V., Lu, Y., Swaidani, S., Misra, S., Deng, L., Chen, Z. J., & Li, X.
- Affiliations
- Cleveland Clinic (US)
- Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44915, USA.
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Liu, Caini
- Qian, Youcun
- Li, Xiaoxia
- ORCID
- Venue
- Science Signaling
- Published
- 2009-10-13
- Volume
- 2
- Issue
- 92
- Pages
- ra63-ra63
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3182834
- OpenAlex
- W2145468317
- Cited by
- 224
- References
- 34
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 3 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 8 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 15
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL098935)
- National Institute of General Medical Sciences (R01GM080271)
- National Institute of Allergy and Infectious Diseases (R01AI065470)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- Act1, U-box E3 ubiquitin ligase, IL-17 signaling, IL-17 receptor, TRAF6, NF-κB activation, Th17 cells, ubiquitination, inflammation
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Mice, Transgenic, Molecular Sequence Data, Mutation, Signal Transduction, Cytokines, Sequence Homology, Amino Acid, Interleukin-17, Ubiquitin-Protein Ligases, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, TNF Receptor-Associated Factor 6, Adaptor Proteins, Signal Transducing, Mice
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