Regulation of NF-κB by ubiquitination

Chen, Jueqi; Chen, Zhijian J

doi:10.1016/j.coi.2012.12.005

Cited by 260NF-κB Signaling PathwaysUbiquitin and proteasome pathwaysNatural Compounds in Disease Treatment

Regulation of NF-κB by ubiquitination

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Chen, Jueqi, Chen, Zhijian J·2013·Current Opinion in Immunology

DOI 10.1016/j.coi.2012.12.005PMC PMC3594545

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Abstract

The nuclear factor κ enhancer binding protein (NF-κB) family of transcription factors regulates the expression of a large array of genes involved in diverse cellular processes including inflammation, immunity and cell survival. Activation of NF-κB requires ubiquitination, a highly conserved and versatile modification that can regulate cell signaling through both proteasome dependent and independent mechanisms. Studies in the past few years have provided new insights into the mechanisms underlying regulation of NF-κB by ubiquitination, including the involvement of multiple linkages of ubiquitin, the essential role of ubiquitin binding, and the function of unanchored polyubiquitin chains. In this review, we will focus on recent advances in understanding the role of ubiquitination in NF-κB regulation in various pathways.

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Ubiquitination plays a key role in regulation of the NF-κB pathway.
“Ubiquitination plays a key role in the regulation of the NF-κB pathway (Chen and Chen 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Chen and Chen 2013

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Authors: Chen, J., & Chen, Z. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Chen, Zhijian J
ORCID: Chen, Jueqi
Chen, Zhijian J
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2013-02
Volume: 25
Issue: 1
Pages: 4-12
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2012.12.005
PMC: PMC3594545
OpenAlex: W2025884466
Cited by: 258
References: 67
Citations by year: 2026: 11 · 2025: 19 · 2024: 11 · 2023: 19 · 2022: 16 · 2021: 29 · 2020: 36 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 12 · 2015: 23 · 2014: 17 · 2013: 6
FWCI: 1.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Welch Foundation
National Institutes of Health
National Institute of General Medical Sciences (R01GM063692)
National Institute of Allergy and Infectious Diseases (R01AI093967)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: NF-κB, ubiquitination, ubiquitin binding, proteasomal degradation, NF-κB activation, inflammation, immunity, cell survival
MeSH terms: Animals, Gene Expression Regulation, Humans, Protein Binding, Structure-Activity Relationship, Ubiquitins, Signal Transduction, Transcriptional Activation, NF-kappa B, Ubiquitination

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Regulation of NF-κB by ubiquitination

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