Luedde, Tom

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Kather, J. N., Pearson, A. T., Halama, N., Jäger, D., Krause, J., Loosen, S. H., Marx, A., Boor, P., Tacke, F., Neumann, U. P., et al. (2019) · Nature Medicine

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

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NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyNF-κB Signaling Pathways

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NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 1,294

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study

Kather, J. N., Krisam, J., Charoentong, P., Luedde, T., Herpel, E., Weis, C.-A., Gaiser, T., Marx, A., Valous, N. A., Ferber, D., et al. (2019) · PLOS Medicine

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

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Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 782

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

Goldmann, T., Wieghofer, P., Müller, P. F., Wolf, Y., Varol, D., Yona, S., Brendecke, S. M., Kierdorf, K., Staszewski, O., Datta, M., et al. (2013) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

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Deep learning in cancer pathology: a new generation of clinical biomarkers

Echle, A., Rindtorff, N. T., Brinker, T. J., Luedde, T., Pearson, A. T., & Kather, J. N. (2021) · British Journal of Cancer

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

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Pharmacological Inhibition of the Chemokine CCL2 (MCP-1) Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury

Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., et al. (2012) · Gut

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

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Apoptosis and necroptosis in the liver: a matter of life and death

Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology

Cell death mechanisms and regulationLiver physiology and pathology

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Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

Krenkel, O., Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., et al. (2018) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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Necroptosis microenvironment directs lineage commitment in liver cancer

Seehawer, M., Heinzmann, F., D’Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., et al. (2018) · Nature

Liver physiology and pathologyCholangiocarcinoma and Gallbladder Cancer Studies

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Inflammatory Pathways in Liver Homeostasis and Liver Injury

Tacke, F., Luedde, T., & Trautwein, C. (2009) · Clinical Reviews in Allergy & Immunology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 393

Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Echle, A., Grabsch, H. I., Quirke, P., van den Brandt, P. A., West, N. P., Hutchins, G. G. A., Heij, L. R., Tan, X., Richman, S. D., Krause, J., et al. (2020) · Gastroenterology

Genetic factors in colorectal cancerAI in cancer detection

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Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Mossanen, J. C., Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., et al. (2016) · Hepatology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

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A positive feedback loop between RIP3 and JNK controls non‐alcoholic steatohepatitis

Gautheron, J., Vucur, M., Reisinger, F., Cardenas, D. V., Roderburg, C., Koppe, C., Kreggenwinkel, K., Schneider, A. T., Bartneck, M., Neumann, U. P., et al. (2014) · EMBO Molecular Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

Ehling, J., Bartneck, M., Wei, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., et al. (2014) · Gut

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

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Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice

Baeck, C., Wei, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., et al. (2014) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

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Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis

Wehr, A., Baeck, C., Heymann, F., Niemietz, P. M., Hammerich, L., Martin, C., Zimmermann, H. W., Pack, O., Gassler, N., Hittatiya, K., et al. (2013) · The Journal of Immunology

Liver physiology and pathologyLiver Diseases and Immunity

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The Fractalkine Receptor CX3CR1 Protects Against Liver Fibrosis by Controlling Differentiation and Survival of Infiltrating Hepatic Monocytes

Karlmark, K. R., Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., & Tacke, F. (2010) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

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Interleukin 6 and liver regeneration

STREETZ, K. L., LUEDDE, T., MANNS, M. P., & TRAUTWEIN, C. (2000) · Gut

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

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Swarm learning for decentralized artificial intelligence in cancer histopathology

Saldanha, O. L., Quirke, P., West, N. P., James, J. A., Loughrey, M. B., Grabsch, H. I., Salto-Tellez, M., Alwers, E., Cifci, D., Ghaffari Laleh, N., et al. (2022) · Nature Medicine

AI in cancer detectionArtificial Intelligence in Healthcare and Education

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Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Krenkel, O., Hundertmark, J., Abdallah, A. T., Kohlhepp, M., Puengel, T., Roth, T., Branco, D. P. P., Mossanen, J. C., Luedde, T., Trautwein, C., et al. (2020) · Gut

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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