Rando, Thomas A.

Chronic inflammation in the etiology of disease across the life span

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

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Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature

Genetics, Aging, and Longevity in Model OrganismsMesenchymal stem cell research

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science

Muscle Physiology and DisordersWnt/β-catenin signaling in development and cancer

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A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

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Molecular regulation of stem cell quiescence

Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

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The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

The Tabula Sapiens Consortium*, Jones, R. C., Karkanias, J., Krasnow, M. A., Pisco, A. O., Quake, S. R., Salzman, J., Yosef, N., Bulthaup, B., Brown, P., et al. (2022) · Science

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

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Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell

Muscle Physiology and DisordersCardiac Fibrosis and Remodeling

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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature

Muscle Physiology and DisordersPI3K/AKT/mTOR signaling in cancer

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Stem cells, ageing and the quest for immortality

Rando, T. A. (2006) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

Brack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., & Rando, T. A. (2008) · Cell Stem Cell

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

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Ageing hallmarks exhibit organ-specific temporal signatures

Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

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Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

Bjornson, C. R. R., Cheung, T. H., Liu, L., Tripathi, P. V., Steeper, K. M., & Rando, T. A. (2012) · Stem Cells

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

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Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports

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H3K4me3 breadth is linked to cell identity and transcriptional consistency

Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science

Neurogenesis and neuroplasticity mechanismsAutophagy in Disease and Therapy

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Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Rando, T. A., & Chang, H. Y. (2012) · Cell

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Collagen VI regulates satellite cell self-renewal and muscle regeneration

Urciuolo, A., Quarta, M., Morbidoni, V., Gattazzo, F., Molon, S., Grumati, P., Montemurro, F., Tedesco, F. S., Blaauw, B., Cossu, G., et al. (2013) · Nature Communications

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Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment

Dhawan, J., & Rando, T. A. (2005) · Trends in Cell Biology

Muscle Physiology and DisordersCongenital heart defects research

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Maintenance of muscle stem-cell quiescence by microRNA-489

Cheung, T. H., Quach, N. L., Charville, G. W., Liu, L., Park, L., Edalati, A., Yoo, B., Hoang, P., & Rando, T. A. (2012) · Nature

Muscle Physiology and DisordersMicroRNA in disease regulation

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Exercise plasma boosts memory and dampens brain inflammation via clusterin

De Miguel, Z., Khoury, N., Betley, M. J., Lehallier, B., Willoughby, D., Olsson, N., Yang, A. C., Hahn, O., Lu, N., Vest, R. T., et al. (2021) · Nature

Neuroinflammation and Neurodegeneration MechanismsClusterin in disease pathology

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Ageing and rejuvenation of tissue stem cells and their niches

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