Cited by 466Muscle Physiology and DisordersCongenital heart defects researchDevelopmental Biology and Gene Regulation

Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment

Dhawan, Jyotsna, Rando, Thomas A.·2005·Trends in Cell Biology

Abstract

Satellite cells are the primary stem cells in adult skeletal muscle, and are responsible for postnatal muscle growth, hypertrophy and regeneration. In mature muscle, most satellite cells are in a quiescent state, but they activate and begin proliferating in response to extrinsic signals. Following activation, a subset of satellite cell progeny returns to the quiescent state during the process of self-renewal. Here, we review recent studies of satellite cell biology and focus on the key transitions from the quiescent state to the state of proliferative activation and myogenic lineage progression and back to the quiescent state. The molecular mechanisms of these transitions are considered in the context of the biology of the satellite cell niche, changes with age, and interactions with established pathways of myogenic commitment and differentiation.

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Crossref · 10.1016/j.tcb.2005.10.007

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Authors
Dhawan, J., & Rando, T. A.
Affiliations
  • Centre for Cellular and Molecular Biology (IN)
  • VA Palo Alto Health Care System (US)
Corresponding author
Rando, Thomas A.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2005-12
Volume
15
Issue
12
Pages
666-673
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2054692433
Cited by
466
References
78
Citations by year
2026: 7 · 2025: 10 · 2024: 6 · 2023: 18 · 2022: 16 · 2021: 22 · 2020: 18 · 2019: 18 · 2018: 11 · 2017: 26 · 2016: 18 · 2015: 25 · 2014: 27 · 2013: 34 · 2012: 40
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
satellite cells, skeletal muscle stem cells, quiescence, cell activation, self-renewal, muscle regeneration, muscle hypertrophy, aging, myogenesis
MeSH terms
Animals, Cell Cycle, Cell Differentiation, Humans, Stem Cells, Gene Expression Regulation, Developmental, Muscle Development, Satellite Cells, Skeletal Muscle, Cell Proliferation

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