Rando, Thomas A.

From geroscience to precision geromedicine: Understanding and managing aging

Kroemer, G., Maier, A. B., Cuervo, A. M., Gladyshev, V. N., Ferrucci, L., Gorbunova, V., Kennedy, B. K., Rando, T. A., Seluanov, A., Sierra, F., et al. (2025) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 395

Stem cells and healthy aging

Goodell, M. A., & Rando, T. A. (2015) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 347

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.

Sarkar, T. J., Quarta, M., Mukherjee, S., Colville, A., Paine, P., Doan, L., Tran, C. M., Chu, C. R., Horvath, S., Qi, L. S., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 308

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

Tang, A. H., & Rando, T. A. (2014) · The EMBO Journal

Muscle Physiology and DisordersAutophagy in Disease and Therapy

Cited by 294

High Incidence of Non-Random Template Strand Segregation and Asymmetric Fate Determination In Dividing Stem Cells and their Progeny

Conboy, M. J., Karasov, A. O., & Rando, T. A. (2007) · PLoS Biology

Developmental Biology and Gene RegulationTelomeres, Telomerase, and Senescence

Cited by 287

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion

Stearns-Reider, K. M., D'Amore, A., Beezhold, K., Rothrauff, B., Cavalli, L., Wagner, W. R., Vorp, D. A., Tsamis, A., Shinde, S., Zhang, C., et al. (2017) · Aging Cell

Muscle Physiology and DisordersTissue Engineering and Regenerative Medicine

Cited by 265

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

Conboy, M. J., Conboy, I. M., & Rando, T. A. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 265

Emerging models and paradigms for stem cell ageing

Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 256

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle

Genetics, Aging, and Longevity in Model OrganismsHematopoietic Stem Cell Transplantation

Cited by 239

Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging

Brack, A. S., & Rando, T. A. (2007) · Stem Cell Reviews

Muscle Physiology and DisordersMesenchymal stem cell research

Cited by 238

Transcriptional profiling of quiescent muscle stem cells in vivo

van Velthoven, C. T. J., de Morree, A., Egner, I. M., Brett, J. O., & Rando, T. A. (2017) · Cell Reports

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

Cited by 235

FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

Gopinath, S. D., Webb, A. E., Brunet, A., & Rando, T. A. (2014) · Stem Cell Reports

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 212

Translational strategies and challenges in regenerative medicine

Dimmeler, S., Ding, S., Rando, T. A., & Trounson, A. (2014) · Nature Medicine

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 179

FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis

Webb, A. E., Pollina, E. A., Vierbuchen, T., Urbán, N., Ucar, D., Leeman, D. S., Martynoga, B., Sewak, M., Rando, T. A., Guillemot, F., et al. (2013) · Cell Reports

FOXO transcription factor regulationNeurogenesis and neuroplasticity mechanisms

Cited by 164

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Brett, J. O., Arjona, M., Ikeda, M., Quarta, M., de Morrée, A., Egner, I. M., Perandini, L. A., Ishak, H. D., Goshayeshi, A., Benjamin, D. I., et al. (2020) · Nature Metabolism

Muscle Physiology and DisordersMesenchymal stem cell research

Cited by 162

HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert

Rodgers, J. T., Schroeder, M. D., Ma, C., & Rando, T. A. (2017) · Cell Reports

Muscle Physiology and DisordersLiver physiology and pathology

Cited by 161

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

Liu, L., Charville, G. W., Cheung, T. H., Yoo, B., Santos, P. J., Schroeder, M., & Rando, T. A. (2018) · Cell Stem Cell

Muscle Physiology and DisordersDevelopmental Biology and Gene Regulation

Cited by 156

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

Alternative Polyadenylation Mediates MicroRNA Regulation of Muscle Stem Cell Function

Boutet, S. C., Cheung, T. H., Quach, N. L., Liu, L., Prescott, S. L., Edalati, A., Iori, K., & Rando, T. A. (2012) · Cell Stem Cell

Muscle Physiology and DisordersRNA Research and Splicing

Cited by 150

Asynchronous, contagious and digital aging

Rando, T. A., & Wyss-Coray, T. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 121

Cell types of origin of the cell-free transcriptome

Vorperian, S. K., Moufarrej, M. N., Tabula Sapiens Consortium, Overall Project Direction and Coordination, Jones, R. C., Karkanias, J., Krasnow, M., Pisco, A. O., Quake, S. R., Salzman, J., et al. (2022) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 116

Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration

Nakayama, K. H., Quarta, M., Paine, P., Alcazar, C., Karakikes, I., Garcia, V., Abilez, O. J., Calvo, N. S., Simmons, C. S., Rando, T. A., et al. (2019) · Communications Biology

Tissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications

Cited by 113

Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function

de Morree, A., Klein, J. D. D., Gan, Q., Farup, J., Urtasun, A., Kanugovi, A., Bilen, B., van Velthoven, C. T. J., Quarta, M., & Rando, T. A. (2019) · Science

Muscle Physiology and DisordersRNA Research and Splicing

Cited by 81

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

Benjamin, D. I., Both, P., Benjamin, J. S., Nutter, C. W., Tan, J. H., Kang, J., Machado, L. A., Klein, J. D. D., de Morree, A., Kim, S., et al. (2022) · Cell Metabolism

Muscle Physiology and DisordersDietary Effects on Health

Cited by 79