MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
Open accessAbstract
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
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Recent findings of a long-range crosstalk between periphery and CNS via miRNA-containing exosomes position the BBB in the center of this communication under physiological and pathophysiological conditions.
“Recent findings of a long-range crosstalk between periphery and CNS via miRNA-containing exosomes position the BBB in the center of this communication (685) under physiological (635, 660) and pathophysiological (378, 493, 498, 587) conditions.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [493]
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- Authors
- Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., Prat, A., Romero, I. A., & de Vries, H. E.
- Affiliations
- Amsterdam Neuroscience (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Hôpital Notre-Dame (CA)
- The Open University (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-17
- Volume
- 33
- Issue
- 16
- Pages
- 6857-6863
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618888
- OpenAlex
- W2084419599
- Cited by
- 138
- References
- 42
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 5
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Open Research Online (The Open University) (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Multiple Sclerosis Society
- ZonMw
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- microRNA, blood-brain barrier, brain endothelial cells, multiple sclerosis, miR-125a-5p, tight junctions, BBB dysfunction, inflammation, BBB repair
- MeSH terms
- Blood-Brain Barrier, Brain, Cell Line, Transformed, Gene Expression Regulation, Genetic Vectors, Humans, Inflammation, Multiple Sclerosis, Transfection, Cytokines, RNA, Small Interfering, MicroRNAs, Endothelial Cells, Transendothelial and Transepithelial Migration
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