Cited by 138Barrier Structure and Function StudiesMicroRNA in disease regulationMultiple Sclerosis Research Studies

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Open access
Reijerkerk, Arie, Lopez-Ramirez, M. Alejandro, van het Hof, Bert, Drexhage, Joost A.R., Kamphuis, Wouter W., Kooij, Gijs, Vos, Joost B., van der Pouw Kraan, Tineke C.T.M. +5 more·2013·The Journal of Neuroscience

Abstract

Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.3965-12.2013

Cites

42 of 42 references verified0 citation errors · 0 not checkable

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  • Recent findings of a long-range crosstalk between periphery and CNS via miRNA-containing exosomes position the BBB in the center of this communication under physiological and pathophysiological conditions.

    “Recent findings of a long-range crosstalk between periphery and CNS via miRNA-containing exosomes position the BBB in the center of this communication (685) under physiological (635, 660) and pathophysiological (378, 493, 498, 587) conditions.”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [493]

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Authors
Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., Prat, A., Romero, I. A., & de Vries, H. E.
Affiliations
  • Amsterdam Neuroscience (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Hôpital Notre-Dame (CA)
  • The Open University (GB)
Venue
The Journal of Neuroscience
Published
2013-04-17
Volume
33
Issue
16
Pages
6857-6863
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2084419599
Cited by
138
References
42
Citations by year
2026: 7 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 5
FWCI
8.98
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Open Research Online (The Open University) (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Funders
  • Multiple Sclerosis Society
  • ZonMw
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
microRNA, blood-brain barrier, brain endothelial cells, multiple sclerosis, miR-125a-5p, tight junctions, BBB dysfunction, inflammation, BBB repair
MeSH terms
Blood-Brain Barrier, Brain, Cell Line, Transformed, Gene Expression Regulation, Genetic Vectors, Humans, Inflammation, Multiple Sclerosis, Transfection, Cytokines, RNA, Small Interfering, MicroRNAs, Endothelial Cells, Transendothelial and Transepithelial Migration

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