Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation
Open accessAbstract
Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal-like” state during PanIN-PDA formation. Here, we demonstrate a parallel mechanism operative in mature duct cells during which functional cells undergo “ductal retrogression” to form IPMN-PDA. We further identify critical antagonistic roles for Brahma-related gene 1 (Brg1), a catalytic subunit of the SWI/SNF complexes, during IPMN-PDA development. In mature duct cells, Brg1 inhibits the dedifferentiation that precedes neoplastic transformation, thus attenuating tumor initiation. In contrast, Brg1 promotes tumorigenesis in full-blown PDA by supporting a mesenchymal-like transcriptional landscape. We further show that JQ1, a drug that is currently being tested in clinical trials for hematological malignancies, impairs PDA tumorigenesis by both mimicking some and inhibiting other Brg1-mediated functions. In summary, our study demonstrates the context-dependent roles of Brg1 and points to potential therapeutic treatment options based on epigenetic regulation in PDA.
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Chromatin regulatory factors may have context-specific and biphasic functions in PDAC, with both tumor suppressor and oncogenic roles at distinct stages of tumorigenesis.
“chromatin regulatory factors may have a more context-specific and biphasic function in PDAC, with studies in autochthonous models suggesting both tumor suppressor and oncogenic functions during distinct stages of tumorigenesis101,102.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [101]
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Cites
Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Conroy, T., Desseigne, F., Ychou, M., Bouché, O., Guimbaud, R., Bécouarn, Y., Adenis, A., Raoul, J.-L., Gourgou-Bourgade, S., de la Fouchardière, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011923 · Cited by 7,810 · see citing works
Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature
Park, P. Y., Goldin, T. A., Chang, J. C. S., Markman, M. M., & Kundranda, M. N. (2015) · Case Reports in Oncology · doi:10.1159/000441772 · Cited by 5,273 · see citing works
Selective inhibition of BET bromodomains
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262 · see citing works
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,820 · see citing works
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2344 · Cited by 1,967 · see citing works
Self-citationMi, H., Muruganujan, A., & Thomas, P. D. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1118 · Cited by 1,693 · see citing works
Genetics and biology of pancreatic ductal adenocarcinomaPreprint
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,570 · see citing works
Kadoch, C., Hargreaves, D. C., Hodges, H. C., Elias, L., Ho, L., Ranish, J. A., & Crabtree, G. R. (2013) · Nature Genetics · doi:10.1038/ng.2628 · Cited by 1,443 · see citing works
Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
Yang, L., Pang, Y., & Moses, H. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.002 · Cited by 1,023 · see citing works
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
Self-citationBardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674 · see citing works
The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers
Shain, A. H., & Pollack, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055119 · Cited by 578 · see citing works
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Morris, J. P., Wang, S. C., & Hebrok, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2899 · Cited by 567 · see citing works
Self-citationPRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
Raedt, T. D., Beert, E., Pasmant, É., Luscan, A., Brems, H., Ortonne, N., Helin, K., Hornick, J. L., Mautner, V., Kehrer‐Sawatzki, H., et al. (2014) · Nature · doi:10.1038/nature13561 · Cited by 463 · see citing works
Inada, A., Nienaber, C. E., Katsuta, H., Fujitani, Y., Levine, J., Morita, R., Sharma, A., & Bonner‐Weir, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805803105 · Cited by 447 · see citing works
Hoffman, G. R., Rahal, R., Buxton, F., Xiang, K., McAllister, G., Frias, E., Bagdasarian, L., Huber, J., Lindeman, A., Chen, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316793111 · Cited by 421 · see citing works
Habbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810097105 · Cited by 410 · see citing works
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
Jean–Paul De La, O., Emerson, L. L., Goodman, J. L., Froebe, S. C., Illum, B. E., Curtis, A. B., & Murtaugh, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810111105 · Cited by 396 · see citing works
Izeradjene, K., Combs, C., Best, M., Gopinathan, A., Wagner, A., Grady, W. M., Deng, C.-X., Hruban, R. H., Adsay, N. V., Tuveson, D. A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.017 · Cited by 379 · see citing works
Ijichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Fujitani, Y., Fujitani, S., Wright, C. V. E., & Moses, H. L. (2006) · Genes & Development · doi:10.1101/gad.1475506 · Cited by 379 · see citing works
Thuault, S., Tan, E., Peinado, H., Cano, A., Heldin, C., & Moustakas, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802016200 · Cited by 365 · see citing works
Sharma, A., Zangen, D., Reitz, P., Taneja, M., Lissauer, M. E., Miller, C. P., Weir, G. C., Habener, J. F., & Bonner‐Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.3.507 · Cited by 331 · see citing works
Melisi, D., Ishiyama, S., Sclabas, G. M., Fleming, J. B., Xia, Q., Tortora, G., Abbruzzese, J. L., & Chiao, P. J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0337 · Cited by 324 · see citing works
Mino-Kenudson, M. A., Castillo, C. F.-D., Baba, Y., Valsangkar, N. P., Liss, A. S., Hsu, M., Correa‐Gallego, C., Ingkakul, T., Johnston, R. P., Turner, B. G., et al. (2011) · Gut · doi:10.1136/gut.2010.232272 · Cited by 292 · see citing works
The BRG1 transcriptional coregulator
Trotter, K. W., & Archer, T. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06004 · Cited by 287 · see citing works
Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexesPreprint
Sif, S., Saurin, A. J., Imbalzano, A. N., & Kingston, R. E. (2001) · Genes & Development · doi:10.1101/gad.872801 · Cited by 283 · see citing works
An elaborate pathway required for Ras-mediated epigenetic silencing
Gazin, C., Wajapeyee, N., Gobeil, S., Virbasius, C.-M. A., & Green, M. R. (2007) · Nature · doi:10.1038/nature06251 · Cited by 282 · see citing works
Vulnerabilities of mutant SWI/SNF complexes in cancer
Helming, K., Wang, X.-F., & Roberts, C. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.018 · Cited by 278 · see citing works
Pal, S., Yun, R., Datta, A., Lacomis, L., Erdjument‐Bromage, H., Kumar, J., Tempst, P., & Sif, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7475-7487.2003 · Cited by 241 · see citing works
Pancreatic ductal cells in development, regeneration, and neoplasia
Reichert, M., & Rustgi, A. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57131 · Cited by 235 · see citing works
Poultsides, G. A., Reddy, S., Cameron, J. L., Hruban, R. H., Pawlik, T. M., Ahuja, N., Jain, A. K., Edil, B. H., Iacobuzio–Donahue, C. A., Schulick, R. D., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181cf8a19 · Cited by 226 · see citing works
Shain, A. H., Giacomini, C. P., Matsukuma, K., Karikari, C. A., Bashyam, M. D., Hidalgo, M., Maitra, A., & Pollack, J. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114817109 · Cited by 221 · see citing works
Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia
Zhu, L., Shi, G., Schmidt, C. M., Hruban, R. H., & Konieczny, S. F. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061176 · Cited by 213 · see citing works
Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Zhang, Y., Morris, J. P., Yan, W., Schofield, H. K., Gurney, A. L., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4384 · Cited by 207 · see citing works
Self-citationWatanabe, S., Ueda, Y., Akaboshi, S.-I., Hino, Y., Sekita, Y., & Nakao, M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080523 · Cited by 201 · see citing works
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190 · see citing works
Self-citationControl of Cell Identity in Pancreas Development and Regeneration
Stanger, B. Z., & Hebrok, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.074 · Cited by 154 · see citing works
Self-citationSinn, M., Denkert, C., Striefler, J. K., Pelzer, U., Stieler, J., Bahra, M., Lohneis, P., Dörken, B., Oettle, H., Riess, H. B., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.495 · Cited by 138 · see citing works
Matthaei, H., Norris, A. L., Tsiatis, A. C., Olino, K. L., Hong, S., Molin, M. D., Goggins, M., Canto, M. I., Horton, K. M., Jackson, K. D., et al. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3182378a18 · Cited by 135 · see citing works
Sun, A., Tawfik, O. W., Gayed, B. A., Thrasher, J. B., Hoestje, S. M., Li, C., & Li, B. (2006) · The Prostate · doi:10.1002/pros.20521 · Cited by 133 · see citing works
Buscarlet, M., Krasteva, V., Ho, L., Simon, C., Hébert, J., Wilhelm, B. T., Crabtree, G. R., Sauvageau, G., Thibault, P., & Lessard, J. A. (2014) · Blood · doi:10.1182/blood-2013-02-483495 · Cited by 124 · see citing works
Naidu, S. R., Love, I. M., Imbalzano, A. N., Grossman, S. R., & Androphy, E. J. (2009) · Oncogene · doi:10.1038/onc.2009.121 · Cited by 122 · see citing works
Fujita, H., Ohuchida, K., Mizumoto, K., Nakata, K., Yu, J., Kayashima, T., Cui, L., Manabe, T., Ohtsuka, T., & Tanaka, M. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181dbf647 · Cited by 118 · see citing works
Elsässer, H. P., Lehr, U., Agricola, B., & Kern, H. F. (1992) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890431 · Cited by 112 · see citing works
Reichert, M., Takano, S., von Burstin, J., Kim, S.-B., Lee, J.-S., Ihida-Stansbury, K., Hahn, C., Heeg, S., Schneider, G., Rhim, A. D., et al. (2013) · Genes & Development · doi:10.1101/gad.204453.112 · Cited by 112 · see citing works
Antagonistic Roles for BRM and BRG1 SWI/SNF Complexes in Differentiation
Flowers, S. J., Nagl, N. G., Beck, G. R., & Morán, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808782200 · Cited by 105 · see citing works
Zhang, X., Li, B., Li, W., Ma, L., Zheng, D., Li, L., Yang, W., Chu, M., Chen, W., Mailman, R. B., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.07.004 · Cited by 104 · see citing works
HMGA2 Elicits EMT by Activating the Wnt/β-catenin Pathway in Gastric Cancer
Zha, L., Zhang, J., Tang, W., Zhang, N., He, M., Guo, Y., & Wang, Z. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2399-6 · Cited by 95 · see citing works
BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen
Sahai, V., Kumar, K., Knab, L. M., Chow, C. R., Raza, S. S., Bentrem, D. J., Ebine, K., & Munshi, H. G. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0925 · Cited by 93 · see citing works
Isolation, culture and genetic manipulation of mouse pancreatic ductal cells
Reichert, M., Takano, S., Heeg, S., Bakir, B. S., Botta, G., & Rustgi, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.079 · Cited by 89 · see citing works
The clinical significance of SWI/SNF complex in pancreatic cancer
Numata, M., Morinaga, S., Watanabe, T., Tamagawa, H., Yamamoto, N., Shiozawa, M., Nakamura, Y., Kameda, Y., Okawa, S., Rino, Y., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1723 · Cited by 89 · see citing works
Sentani, K., Oue, N., Kondo, H., Kuraoka, K., Motoshita, J., Ito, R., Yokozaki, H., & Yasui, W. (2001) · Pathobiology · doi:10.1159/000064638 · Cited by 76 · see citing works
Molin, M. D., Hong, S., Hebbar, S., Sharma, R. B., Scrimieri, F., de Wilde, R. F., Mayo, S. C., Goggins, M., Wolfgang, C. L., Schulick, R. D., et al. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.06.009 · Cited by 65 · see citing works
BRG1 expression is increased in human cutaneous melanoma
Lin, H., Wong, R. P. C., Martinka, M., & Li, G. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09851.x · Cited by 64 · see citing works
Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms
Park, J. Y., Hong, S., Klimstra, D. S., Goggins, M., Maitra, A., & Hruban, R. H. (2011) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e318206d958 · Cited by 64 · see citing works
Ischenko, I., Petrenko, O., & Hayman, M. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319911111 · Cited by 62 · see citing works
Ostapoff, K. T., Cenik, B. K., Wang, M., Ye, R., Xu, X. N., Nugent, D. P., Hagopian, M. M., Topalovski, M., Rivera, L. B., Carroll, K. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1807 · Cited by 59 · see citing works
BRG1 promotes chemoresistance of pancreatic cancer cells through crosstalking with Akt signalling
Liu, X., Tian, X., Wang, F., Ma, Y., Kornmann, M., & Yang, Y. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.05.017 · Cited by 44 · see citing works
Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase
Watanabe, H., Saitō, H., Ueda, J., & Evers, B. M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.012 · Cited by 23 · see citing works
Abstract 4909: Olig2 phosphorylation by CDK2 implicated in glioma proliferation.
Fu, J., Koul, D., Zheng, S., Singh, V., Yao, J., Zheng, Y., Lu, Z., Sulman, E. P., Lang, F. F., & Yung, A. W. K. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-4909 · Cited by 5 · see citing works
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Weischenfeldt, J., Dubash, T., Drainas, A. P., Mardin, B. R., Chen, Y., Stütz, A. M., Waszak, S. M., Bosco, G., Halvorsen, A. R., Raeder, B., et al. (2017) · Nature Genetics · doi:10.1038/ng.3722 · Cited by 404 · see citing works
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Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620164114 · Cited by 147 · see citing works
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- Authors
- Roy, N., Malik, S., Villanueva, K. E., Urano, A., Lu, X., Von Figura, G., Seeley, E. S., Dawson, D. W., Collisson, E. A., & Hebrok, M.
- Affiliations
- University of California, San Francisco (US)
- University of California, Los Angeles (US)
- Corresponding author
- Hebrok, Matthias
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-03-15
- Volume
- 29
- Issue
- 6
- Pages
- 658-671
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC4378197
- OpenAlex
- W2112350662
- Cited by
- 155
- References
- 64
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 15 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- National Institutes of Health (R01CA172045)
- National Cancer Institute (R01CA112537)
- NIH (R01CA178015)
- NCI (K08CA137153)
- American Association of Cancer Research
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- SMARCA4, pancreatic ductal adenocarcinoma, intraductal papillary mucinous neoplasm, pancreatic intraepithelial neoplasia, SWI/SNF complex, dedifferentiation, tumor initiation, JQ1, epigenetic regulation, tumor suppressor, oncogenic transformation
- MeSH terms
- Animals, Azepines, Cell Transformation, Neoplastic, DNA Helicases, Humans, Nuclear Proteins, Pancreatic Neoplasms, Transcription Factors, Triazoles, Tumor Cells, Cultured, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Carcinoma, Pancreatic Ductal, Mice, SOX9 Transcription Factor
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