Wirtz, Stefan

Chemically induced mouse models of acute and chronic intestinal inflammation

Wirtz, S., Popp, V., Kindermann, M., Gerlach, K., Weigmann, B., Fichtner-Feigl, S., & Neurath, M. F. (2017) · Nature Protocols

Inflammatory Bowel DiseaseOcular Diseases and Behçet’s Syndrome

Cited by 1,575

Chemically induced mouse models of intestinal inflammation

Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. (2007) · Nature Protocols

Inflammatory Bowel DiseaseOcular Diseases and Behçet’s Syndrome

Cited by 1,567

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., et al. (2000) · Nature Medicine

Inflammatory Bowel DiseaseCytokine Signaling Pathways and Interactions

Cited by 1,293

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,048

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsInflammatory Bowel Disease

Cited by 1,043

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H. A., Wirtz, S., Becker, C., Atreya, R., et al. (2003) · Journal of Clinical Investigation

Protein Kinase Regulation and GTPase SignalingCell death mechanisms and regulation

Cited by 828

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity

TGF-β signaling in diseasesCytokine Signaling Pathways and Interactions

Cited by 726

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

Mchedlidze, T., Waldner, M., Zopf, S., Walker, J., Rankin, A. L., Schuchmann, M., Voehringer, D., McKenzie, A. N. J., Neurath, M. F., Pflanz, S., et al. (2013) · Immunity

IL-33, ST2, and ILC PathwaysLiver physiology and pathology

Cited by 502

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

Gerlach, K., Hwang, Y., Nikolaev, A., Atreya, R., Dornhoff, H., Steiner, S., Lehr, H.-A., Wirtz, S., Vieth, M., Waisman, A., et al. (2014) · Nature Immunology

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 407

The intestinal microbiota in inflammatory bowel disease

Becker, C., Neurath, M. F., & Wirtz, S. (2015) · ILAR Journal

Gut microbiota and healthInflammatory Bowel Disease

Cited by 185

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Günther, C., He, G.-W., Kremer, A. E., Murphy, J. M., Petrie, E. J., Amann, K., Vandenabeele, P., Linkermann, A., Poremba, C., Schleicher, U., et al. (2016) · Journal of Clinical Investigation

Cell death mechanisms and regulationLiver Diseases and Immunity

Cited by 157

Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones

Schapher, M., Koch, M., Weidner, D., Scholz, M., Wirtz, S., Mahajan, A., Herrmann, I., Singh, J., Knopf, J., Leppkes, M., et al. (2020) · Cells

Salivary Gland Disorders and FunctionsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 47

Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates

Cosma-Grigorov, A., Meixner, H., Mrochen, A., Wirtz, S., Winkler, J., & Marxreiter, F. (2020) · Frontiers in Neurology

Gut microbiota and healthParkinson's Disease Mechanisms and Treatments

Cited by 38

PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells

Gerlach, K., Popp, V., Wirtz, S., Al-Saifi, R., Gonzalez Acera, M., Atreya, R., Dregelies, T., Vieth, M., Fichtner-Feigl, S., McKenzie, A. N. J., et al. (2022) · Journal of Crohn's and Colitis

T-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

Cited by 25