The intestinal microbiota in inflammatory bowel disease
Abstract
The intestinal microbiota has important metabolic and host-protective functions. Conversely to these beneficial functions, the intestinal microbiota is thought to play a central role in the etiopathogenesis of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), a chronic inflammation of the gut mucosa. Genetic screens and studies in experimental mouse models have clearly demonstrated that IBD can develop due to excessive translocation of bacteria into the bowel wall or dysregulated handling of bacteria in genetically susceptible hosts. In healthy individuals, the microbiota is efficiently separated from the mucosal immune system of the gut by the gut barrier, a single layer of highly specialized epithelial cells, some of which are equipped with innate immune functions to prevent or control access of bacterial antigens to the mucosal immune cells. It is currently unclear whether the composition of the microbial flora or individual bacterial strains or pathogens induces or supports the pathogenesis of IBD. Further research will be necessary to carefully dissect the contribution of individual bacterial species to this disease and to ascertain whether specific modulation of the intestinal microbiome may represent a valuable further option for future therapeutic strategies.
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The gastrointestinal tract is constantly confronted with food antigens, possible pathogens, and symbiotic intestinal microbiota that present a risk factor for intestinal inflammation.
“The gastrointestinal tract is constantly confronted with food antigens, possible pathogens, and symbiotic intestinal microbiota that present a risk factor for intestinal inflammation (63).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [63]
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Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works
“immune Homeostasis The gastrointestinal tract is constantly confronted with food antigens, possible pathogens, and symbiotic intestinal microbiota that present a risk factor for intestinal inflammation (63).”
BackgroundSartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works
Dolinger, M. T., Torres, J., & Vermeire, S. (2024) · The Lancet · doi:10.1016/s0140-6736(23)02586-2 · Cited by 617 · see citing works
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“adherent/invasive Escherichia coli) [3, 4], the majority of bacterial species that characterize the dysbiosis of IBD have not been fully identified.”
BackgroundResultInfluentialAnanthakrishnan, A. N., Luo, C., Yajnik, V., Khalili, H., Garber, J. J., Stevens, B. W., Cleland, T., & Xavier, R. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.010 · Cited by 451 · see citing works
“The gut microbiome is a key determinant of initiation and propagation of luminal inflammation in IBD(Becker et al., 2015; Forbes et al., 2016; Gevers et al., 2014; Knights et al., 2013; Kostic et al., 2014).”
BackgroundInfluentialThe Gut Microbiota in Immune-Mediated Inflammatory Diseases
Forbes, J. D., Domselaar, G. V., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 430 · see citing works
Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease
Zhang, M., Sun, K., Wu, Y., Yang, Y., Tso, P., & Wu, Z. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00942 · Cited by 347 · see citing works
“However, it should be kept in mind that the diversity and composition of bacteria among experimental animal studies or IBD patients are not consistent, and the results are contradictory under some conditions (72).”
BackgroundResultInfluentialDietary simple sugars alter microbial ecology in the gut and promote colitis in mice
Khan, S., Waliullah, S., Godfrey, V., Khan, M. A. W., Ramachandran, R. A., Cantarel, B. L., Behrendt, C. L., Peng, L., Hooper, L. V., & Zaki, H. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6218 · Cited by 322 · see citing works
“exerts protective functions and maintains gut homeostasis through multiple mechanisms including induction of anti-inflammatory cytokines and protection against colonization of pathobionts to intestinal epithelium (55).”
BackgroundTryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis
Kaur, H., Bose, C., & Mande, S. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01365 · Cited by 320 · see citing works
The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors
Lobionda, S., Sittipo, P., Kwon, H. Y., & Lee, Y. K. (2019) · Microorganisms · doi:10.3390/microorganisms7080271 · Cited by 319 · see citing works
“Proteobacteria species, belonging to the Enterobacteriaceae phylum, are commonly observed to be abundant in specific diseases, including inflammatory bowel disease (IBD) [15,19].”
BackgroundInfluentialIngestible electronics for diagnostics and therapy
Steiger, C., Abramson, A., Nadeau, P., Chandrakasan, A. P., Langer, R., & Traverso, G. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0070-3 · Cited by 278 · see citing works
Risk of colorectal cancer in inflammatory bowel diseases
Nadeem, M. S., Kumar, V., Al-Abbasi, F. A., Kamal, M. A., & Anwar, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.001 · Cited by 250 · see citing works
Fábrega, M.-J., Rodríguez-Nogales, A., Garrido-Mesa, J., Algieri, F., Badía, J., Giménez, R., Gálvez, J., & Baldomà, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01274 · Cited by 240 · see citing works
“Different letters indicate significant differences between groups (P < 0.05). genetically susceptible individuals, leading to the inflammatory status that characterizes these intestinal conditions (Becker et al., 2015).”
BackgroundInfluentialRintala, A., Pietilä, S., Munukka, E., Eerola, E., Pursiheimo, J.-P., Laiho, A., Pekkala, S., & Huovinen, P. (2017) · Journal of Biomolecular Techniques : JBT · doi:10.7171/jbt.17-2801-003 · Cited by 194 · see citing works
Intestinal microbiota mediates Enterotoxigenic Escherichia coli-induced diarrhea in piglets
Bin, P., Tang, Z., Liu, S., Chen, S., Xia, Y., Liu, J., Wu, H., & Zhu, G. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1704-9 · Cited by 158 · see citing works
Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health
Bedu-Ferrari, C., Biscarrat, P., Langella, P., & Cherbuy, C. (2022) · Nutrients · doi:10.3390/nu14102096 · Cited by 153 · see citing works
“Thus, diabetes [11], cardiovascular disease [12,13], obesity [14], inflammatory bowel disease [15,16], and non-alcoholic fatty liver disease (NAFLD) are examples of diseases associated with a shift in microbial patterns compared to healthy individuals [17].”
BackgroundIntestinal Bacteria Composition and Translocation of Bacteria in Inflammatory Bowel Disease
Vrakas, S., Mountzouris, K. C., Michalopoulos, G., Karamanolis, G. P., Papatheodoridis, G., Tzathas, C., & Gazouli, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170034 · Cited by 130 · see citing works
Hirano, A., Umeno, J., Okamoto, Y., Shibata, H., Ogura, Y., Moriyama, T., Torisu, T., Fujioka, S., Fuyuno, Y., Kawarabayasi, Y., et al. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14129 · Cited by 129 · see citing works
Xie, J., Liu, Y., Chen, B., Zhang, G., Ou, S., Luo, J., & Peng, X. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.1559 · Cited by 128 · see citing works
“of IBD, as indicated by experimental mouse model studies that demonstrated that the development of IBD was due to excessive translocation of bacteria into the bowel wall or the dysregulation of bacteria in genetically susceptible hosts (4).”
MethodAlemany-Cosme, E., González, E. S., Moret, I., Mateos, B., Iborra, M., Nos, P., Sandoval, J., & Beltrán, B. (2021) · Antioxidants · doi:10.3390/antiox10010064 · Cited by 127 · see citing works
“Most of these genes play an important role in the mucosal barrier function, antimicrobial recognition and function, and immune regulation [61].”
BackgroundEftychi, C., Schwarzer, R., Vlantis, K., Wachsmuth, L., Basic, M., Wagle, P., Neurath, M. F., Becker, C., Bleich, A., & Pasparakis, M. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.008 · Cited by 118 · see citing works
Self-citationAhlawat, S., Kumar, P., Mohan, H., Goyal, S., & Sharma, K. K. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1876631 · Cited by 111 · see citing works
Han, B., Lv, X., Liu, G., Li, S., Fan, J., Chen, L., Huang, Z., Lin, G., Xu, X., Huang, Z., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2232143 · Cited by 116 · see citing works
“, Firmicutes) decreased.(3,19,21) Recently, the baseline gut microbiota was used to predict the treatment response in a prospective study of IBD patients receiving anti-α4β7-integrin as an initial treatment, and the researchers discovered that remission-achieving CD patients at week 14 had higher baseline levels of Ro…”
Resolution of ulcerative colitis
Neurath, M. F., & Leppkes, M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00751-6 · Cited by 103 · see citing works
Self-citationINTESTINAL MICROBIOTA IN DIGESTIVE DISEASES
Passos, M. D. C. F., & Moraes-Filho, J. P. P. (2017) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.201700000-31 · Cited by 101 · see citing works
Alteration of the Gut Microbiome in Inflammatory Bowel Disease
Andoh, A., & Nishida, A. (2023) · Digestion · doi:10.1159/000525925 · Cited by 88 · see citing works
Gut microbiome: a new player in gastrointestinal disease
Gorkiewicz, G., & Moschen, A. R. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2277-x · Cited by 87 · see citing works
“tified not only significant compositional alterations of the microbiome with reduction of potentially-protective commensals such as Faecalibacterium prausnitzii [113] but also a less”
BackgroundBacterial associations in the healthy human gut microbiome across populations
Loftus, M. G., Hassouneh, S. A.-D., & Yooseph, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-82449-0 · Cited by 77 · see citing works
de Bruyn, M., Vandooren, J., Ugarte-Berzal, E., Arijs, I., Vermeire, S., & Opdenakker, G. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1199535 · Cited by 77 · see citing works
“In IBD, an imbalance in the composition of the gut microbiota, termed dysbiosis, has been determined to play an important role in the disease pathogenesis (Becker et al, 2015; Kamada et al, 2013; Round & Mazmanian, 2009; Sartor, 2008).”
BackgroundDovrolis, N., Michalopoulos, G., Theodoropoulos, G. E., Arvanitidis, K. I., Kolios, G. C., Sechi, L. A., Eliopoulos, A. G., & Gazouli, M. (2020) · Microorganisms · doi:10.3390/microorganisms8030438 · Cited by 73 · see citing works
“Unfortunately, this approach also prohibits us from detecting low-burden infections from bacteria that, for example, reside in mesenteric lymph nodes like the Mycobacterium avium paratuberculosis, which has been implicated in previous IBD studies [41,42], even though we detected an increase in other Actinobacteria lik…”
BackgroundVitamin A supplementation ameliorates ulcerative colitis in gut microbiota–dependent manner
Pang, B., Han, J., Liao, N., Li, J., Jiang, C., & Shi, J. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110568 · Cited by 76 · see citing works
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients
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“Animal models of IBD suggest that not all bacterial species are created equal when it comes to inducing inflammation of the gastrointestinal tract [130,131]; hence it is not reasonable to expect that all antibiotic regimens will be similarly effective in all groups of patients.”
BackgroundIs there a relationship between intestinal microbiota, dietary compounds, and obesity?
Kałużna‐Czaplińska, J., Gątarek, P., Chartrand, M. S., Dadar, M., & Bjørklund, G. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.10.010 · Cited by 72 · see citing works
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“Additionally, several bacterial pathogens have been implicated in the onset or progression of the disease (10).”
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“coli translocation and in probiotic diversity and concentrations.[13,54,94] E.”
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“Disturbance of normal gut microbiota (dysbiosis) has been implicated in the pathogenesis of diverse clinical conditions, such as obesity [1], type 2 diabetes [2], inflammatory bowel disease [3], and cardiovascular [4] and neurological diseases [5].”
BackgroundTranscriptional Signatures That Define Ulcerative Colitis in Remission
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“As research on the intestinal microbiota continues to deepen, researchers have found a close relationship between intestinal inflammatory diseases as well as intestinal health and intestinal microbiota in piglets [9].”
BackgroundGut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases
Pan, I., Issac, P. K., Rahman, M. M., Guru, A., & Arockiaraj, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03691-3 · Cited by 60 · see citing works
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“Lactobacillus could induce the expression of anti-inflammatory cytokines and prevent the colonization of pathogens into the intestinal epithelium, thus maintaining intestinal homeostasis (47).”
BackgroundThe influence of vitamin D on M1 and M2 macrophages in patients with Crohn's disease
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Gut microbiota imbalance mediates intestinal barrier damage in high‐altitude exposed mice
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The gut dysbiosis-cancer axis: illuminating novel insights and implications for clinical practice
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“Microbial dysbiosis is characterized by a shift from a diverse bacterial composition to a maladaptive and pathogenic one, and has been linked to numerous diseases, including diabetes, cardiovascular disease, obesity, inflammatory bowel disease, and various cancers (Koren et al., 2011; Karlsson et al., 2012; Karlsson e…”
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“coliwas generally detected in a smaller percentage in feces and saliva (Becker et al., 2015), this result suggested that it was a marked etiological agent of AC and that dysbiosis may be related to postoperative complications.”
BackgroundCombined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis
Sun, M., Du, B., Shi, Y., Lu, Y., Zhou, Y. Y., & Liu, B.-R. (2019) · Medical Science Monitor · doi:10.12659/msm.916009 · Cited by 51 · see citing works
“Inflammatory bowel disease (IBD) involves chronic, idiopathic, and relapsing inflammation in the gastrointestinal (GI) tract, including Crohn’s disease (CD) and ulcerative colitis (UC) [1].”
BackgroundNatural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease
Li, B., Wang, Y., Jiang, X., Du, H., Shi, Y., Xiu, M., Liu, Y., & He, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114950 · Cited by 50 · see citing works
Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the Gut
Liebing, E., Krug, S. M., Neurath, M. F., Siegmund, B., & Becker, C. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101423 · Cited by 52 · see citing works
Self-citationComposition of the Intestinal Microbiota Determines the Outcome of Virus-Triggered Colitis in Mice
Bolsega, S., Basic, M., Smoczek, A., Büettner, M., Eberl, C., Ahrens, D., Odum, K. A., Stecher, B., & Bleich, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01708 · Cited by 50 · see citing works
“The intestinal microbiota was shown to be crucial for the development of IBD, while genetic susceptibility and environmental factors can also play an important role (13, 14).”
BackgroundBamola, V. D., Dubey, D., Samanta, P., Kedia, S., Ahuja, V., Madempudi, R. S., Neelamraju, J., & Chaudhry, R. (2022) · Anaerobe · doi:10.1016/j.anaerobe.2022.102652 · Cited by 53 · see citing works
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Crosstalk between microbiota, pathogens and the innate immune responses
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“So far, many experts believe that the dysbiosis of intestinal microbiota can lead to the dysregulation of the immune response to bacterial antigens, and ultimately leads to the occurrence of IBD (45, 46).”
BackgroundInfluentialHaange, S., Jehmlich, N., Hoffmann, M., Weber, K., Lehmann, J., von Bergen�, M., & Slanina, U. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00974 · Cited by 43 · see citing works
Qi, M., Cao, Z., Shang, P., Zhang, H., Hussain, R., Mehmood, K., Chang, Z., Wu, Q., & Dong, H. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105106 · Cited by 43 · see citing works
Models to evaluate the barrier properties of mucus during drug diffusion
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“In response to various stresses, such as inflammation and antibi‐ otics, the microbial diversity decreases, the normal bacterial functions cannot be performed and anecological imbalance occurs, which indicates that the gut microbiota diversity is required to maintain balance (13,46,55,56).”
BackgroundSchmidt, J., Weigert, M., Leuschner, C., Hartmann, H., Raddatz, D., Haak, R., Mausberg, R. F., Kottmann, T., Schmalz, G., & Ziebolz, D. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0486 · Cited by 40 · see citing works
“Tf IBD 24 (41) 5 (8) 3 (5) 11 (19) 16 (27) 59 % 0.”
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“Indeed, fecal microbiota transplantation has been developed as a new promising therapeutics for treatment of several gut inflammatory diseases [97].”
BackgroundThe Mammalian Microbiome and Its Importance in Laboratory Animal Research
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“Effects of the intestinal microbiota on the host are reviewed by Becker and colleagues and Hörmannsperger and colleagues (Becker et al. 2015; Hörmannsperger et al. 2015).”
BackgroundNiu, W., Yang, F., Fu, Z., Dong, Y., Zhang, Z., & Ju, J. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105381 · Cited by 39 · see citing works
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Treatment of murine colitis by Saccharomyces boulardii secreting atrial natriuretic peptide
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“It is generally accepted that the abnormal alteration of gut microbiota plays an important role in IBD pathogenesis [18], and the ability of probiotics to positively regulate the gut flora can be beneficial to the disease [19, 20].”
BackgroundStolzer, I., Kaden-Volynets, V., Ruder, B., Letizia, M., Bittel, M., Rausch, P., Basic, M., Bleich, A., Baines, J. F., Neurath, M. F., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz142 · Cited by 31 · see citing works
Self-citationWang, Y., Song, X., Wang, Z., Li, Z., & Geng, Y. (2023) · Polymers · doi:10.3390/polym15061414 · Cited by 32 · see citing works
“Gut flora plays a key role in the metabolism, development, and function of the host immune system [12].”
BackgroundPeng-fei, X., Lv, T., Dong, S., Cui, Z., Luo, X., Jia, B., Jeon, C. O., & Zhang, J. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.04.006 · Cited by 31 · see citing works
“However, there is no evidence that changes in intestinal microbes are the cause or result of IBD [56].”
BackgroundMucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects
Kashiwagi, S., Naito, Y., Inoüe, R., Takagi, T., Nakano, T., Inada, Y., Fukui, A., Katada, K., Mizushima, K., Kamada, K., et al. (2019) · Digestion · doi:10.1159/000496102 · Cited by 31 · see citing works
Exposure to copper altered the intestinal microbiota in Chinese brown frog (Rana chensinensis)
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Loss of RHBDF2 results in an early-onset spontaneous murine colitis
Geesala, R., Schanz, W., Biggs, M., Dixit, G., Skurski, J., Gurung, P., Meyerholz, D. K., Elliott, D. E., Issuree, P. D. A., & Maretzky, T. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0718-283rr · Cited by 30 · see citing works
Prevalence of allergic diseases in children with inflammatory bowel disease
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Innate lymphoid cells in intestinal cancer development
Atreya, I., Kindermann, M., & Wirtz, S. J. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.02.001 · Cited by 28 · see citing works
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Microbiota, not host origin drives ex vivo intestinal epithelial responses
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Farhadfar, N., Gharaibeh, R. Z., Dahl, W. J., Mead, L., Alabasi, K. M., Newsome, R. C., Irizarry-Gatell, V., Weaver, M. T., Al‐Mansour, Z., Jobin, C., et al. (2021) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2021.02.017 · Cited by 25 · see citing works
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Precision medicine and drug optimization in adult inflammatory bowel disease patients
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A phytopharmacological overview of medicinal plants used for prophylactic and treatment of colitis
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Bosch, S., Wintjens, D., Wicaksono, A. N., Kuijvenhoven, J. P., van der Hulst, R. W. M., Stokkers, P. C. F., Daulton, E., Pierik, M. J., Covington, J. A., de Meij, T. G. J., et al. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.03.007 · Cited by 22 · see citing works
Role of melatonin in murine “restraint stress”-induced dysfunction of colonic microbiota
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Interleukin-37 exacerbates experimental colitis in an intestinal microbiome-dependent fashion
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“It can cause colon inflammation by allowing more bacteria to translocate to the laminal propria compartment and triggering inappropriate host immune responses when confronted with the commensal microbiota [3-6].”
BackgroundAn improved rat model for chronic inflammatory bowel disease
Ghattamaneni, N. K. R., Panchal, S. K., & Brown, L. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.10.006 · Cited by 22 · see citing works
“During dysbiosis in IBD, decreases in Firmicutes and Bacteroidetes are observed with increases in Proteobacteria and Actinobacteria [27].”
BackgroundInfluentialRegulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation
Schulz-Kuhnt, A., Wirtz, S. J., Neurath, M. F., & Atreya, I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01062 · Cited by 21 · see citing works
Self-citationFeatures of the gut prokaryotic virome of Japanese patients with Crohn’s disease
Imai, T., Inoüe, R., Nishida, A., Yokota, Y., Morishima, S., Kawahara, M., Kusada, H., Tamaki, H., & Andoh, A. (2022) · Journal of Gastroenterology · doi:10.1007/s00535-022-01882-8 · Cited by 20 · see citing works
Chamorro, N., Montero, D. A., Gallardo, P., Farfán, M. J., Mauricio Contreras, G., la Fuente, M. D., Dubois‐Camacho, K., Hermoso, M. A., Quera, R., Pizarro‐Guajardo, M., et al. (2021) · Microbial Cell · doi:10.15698/mic2021.09.760 · Cited by 21 · see citing works
“Previous studies have also shown the same alteration in the abundance of these phyla in the mucosa-associated microbiota of IBD patients [35, 63, 64].”
ResultRajesh, K. M., Kinra, M., Ranadive, N., Pawaskar, G. M., Mudgal, J., & Raval, R. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02710-3 · Cited by 18 · see citing works
“Chronic inflammatory gastrointestinal tract disorders fall under the umbrella term of Inflammatory Bowel Disease (IBD), which encompasses conditions such as ulcerative colitis (UC) and Crohn disease (CD) (Becker et al. 2015b).”
BackgroundJatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression
Zhang, J. L., Zhang, M.-N., Wang, H., Yang, X. Z., & Yu, C. G. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00514-z · Cited by 17 · see citing works
“Discussion Several studies have shown evidence that gut dysbiosis is closely related to UC [33, 34].”
BackgroundGao, R., Wang, C., Aricha, H., Tian, Y., Ren, S., Lv, W., Chen, A., & Zhang, J. (2021) · Animals · doi:10.3390/ani11113314 · Cited by 17 · see citing works
“Alterations in the composition of the gut microbiota can lead to a variety of diseases and dysfunctions, including inflammatory bowel disease [6], obesity [7], colorectal cancer [8], and type 2 diabetes [9].”
Background
- Authors
- Becker, C., Neurath, M. F., & Wirtz, S.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Becker, Christoph
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-08-31
- Volume
- 56
- Issue
- 2
- Pages
- 192-204
- ISSN
- 1084-2020 (ISSN-L)
- 1930-6180
- OpenAlex
- W2235910927
- Cited by
- 185
- References
- 144
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 14 · 2023: 15 · 2022: 31 · 2021: 25 · 2020: 20 · 2019: 24 · 2018: 11 · 2017: 18 · 2016: 9 · 2015: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ILAR Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, inflammatory bowel disease, Crohn's disease, ulcerative colitis, intestinal barrier, mucosal immunity, bacterial translocation, host susceptibility, microbiota modulation, treatment options
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Models, Animal
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