Mills, Evanna L.

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell

Immune cells in cancerMitochondrial Function and Pathology

Cited by 2,291

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

Cited by 1,885

Mitochondria are the powerhouses of immunity

Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology

Mitochondrial Function and PathologyImmune Response and Inflammation

Cited by 1,161

Succinate: a metabolic signal in inflammation

Mills, E., & O’Neill, L. A. J. (2014) · Trends in Cell Biology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 741

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 571

Accumulation of succinate controls activation of adipose tissue thermogenesis

Mills, E. L., Pierce, K. A., Jedrychowski, M. P., Garrity, R., Winther, S., Vidoni, S., Yoneshiro, T., Spinelli, J. B., Lu, G. Z., Kazak, L., et al. (2018) · Nature

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 539

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 398

pH-gated succinate secretion regulates muscle remodeling in response to exercise

Reddy, A., Bozi, L. H. M., Yaghi, O. K., Mills, E. L., Xiao, H., Nicholson, H. E., Paschini, M., Paulo, J. A., Garrity, R., Laznik-Bogoslavski, D., et al. (2020) · Cell

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 279

Inflammasome Priming in Sterile Inflammatory Disease

Patel, M. N., Carroll, R. G., Galván-Peña, S., Mills, E. L., Olden, R., Triantafilou, M., Wolf, A. I., Bryant, C. E., Triantafilou, K., & Masters, S. L. (2017) · Trends in Molecular Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 241

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease

Guillot-Sestier, M.-V., Araiz, A. R., Mela, V., Gaban, A. S., O’Neill, E., Joshi, L., Chouchani, E. T., Mills, E. L., & Lynch, M. A. (2021) · Communications Biology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 182