Lavine, Kory J.

Origin and functions of tissue macrophages

Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 1,585

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 1,494

Macrophages Facilitate Electrical Conduction in the Heart

Hulsmans, M., Clauss, S., Xiao, L., Aguirre, A. D., King, K. R., Hanley, A., Hucker, W. J., Wülfers, E. M., Seemann, G., Courties, G., et al. (2017) · Cell

Cardiac electrophysiology and arrhythmiasConnexins and lens biology

Cited by 1,011

Self-Renewing Resident Cardiac Macrophages Limit Adverse Remodeling Following Myocardial Infarction

Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., et al. (2019) · Nature Immunology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 883

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 818

Spatial multi-omic map of human myocardial infarction

Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., et al. (2022) · Nature

Single-cell and spatial transcriptomicsCongenital heart defects research

Cited by 772

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

Bajpai, G., Bredemeyer, A., Li, W., Zaitsev, K., Koenig, A. L., Lokshina, I., Mohan, J., Ivey, B., Hsiao, H.-M., Weinheimer, C., et al. (2019) · Circulation Research

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 751

The human heart contains distinct macrophage subsets with divergent origins and functions

Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., et al. (2018) · Nature Medicine

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 712

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Koenig, A. L., Shchukina, I., Amrute, J., Andhey, P. S., Zaitsev, K., Lai, L., Bajpai, G., Bredemeyer, A., Smith, G., Jones, C., et al. (2022) · Nature Cardiovascular Research

Single-cell and spatial transcriptomicsCardiac Fibrosis and Remodeling

Cited by 482

Targeting immune–fibroblast cell communication in heart failure

Amrute, J. M., Luo, X., Penna, V., Yang, S., Yamawaki, T., Hayat, S., Bredemeyer, A., Jung, I.-H., Kadyrov, F. F., Heo, G. S., et al. (2024) · Nature

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 339

The Macrophage in Cardiac Homeostasis and Disease

Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 234

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

Bailey, A. L., Dmytrenko, O., Greenberg, L., Bredemeyer, A. L., Ma, P., Liu, J., Penna, V., Winkler, E. S., Sviben, S., Brooks, E., et al. (2021) · JACC: Basic to Translational Science

Viral Infections and Immunology ResearchCOVID-19 Clinical Research Studies

Cited by 193

Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

Ma, P., Liu, J., Qin, J., Lai, L., Heo, G. S., Luehmann, H., Sultan, D., Bredemeyer, A., Bajapa, G., Feng, G., et al. (2024) · Circulation

Cancer Immunotherapy and BiomarkersViral Infections and Immunology Research

Cited by 187

Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression

Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 180

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development

Luo, X., Fu, Y., Loza, A. J., Murali, B., Leahy, K. M., Ruhland, M. K., Gang, M., Su, X., Zamani, A., Shi, Y., et al. (2016) · Cell Reports

Bone health and treatmentsTelomeres, Telomerase, and Senescence

Cited by 141

Basophils balance healing after myocardial infarction via IL-4/IL-13

Sicklinger, F., Meyer, I. S., Li, X., Radtke, D., Dicks, S., Kornadt, M. P., Mertens, C., Meier, J. K., Lavine, K. J., Zhang, Y., et al. (2021) · Journal of Clinical Investigation

Cardiac Fibrosis and RemodelingMast cells and histamine

Cited by 88

Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

Amrute, J. M., Lai, L., Ma, P., Koenig, A. L., Kamimoto, K., Bredemeyer, A., Shankar, T. S., Kuppe, C., Kadyrov, F. F., Schulte, L. J., et al. (2023) · Nature Cardiovascular Research

Cardiac Fibrosis and RemodelingMechanical Circulatory Support Devices

Cited by 79

Transcriptional and Immune Landscape of Cardiac Sarcoidosis

Liu, J., Ma, P., Lai, L., Villanueva, A., Koenig, A., Bean, G. R., Bowles, D. E., Glass, C., Watson, M., Lavine, K. J., et al. (2022) · Circulation Research

Sarcoidosis and Beryllium Toxicity ResearchViral Infections and Immunology Research

Cited by 78

New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity

Rhee, A. J., & Lavine, K. J. (2020) · Annual Review of Physiology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 46

NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy

Chelko, S. P., Penna, V. R., Engel, M., Shiel, E. A., Centner, A. M., Farra, W., Cannon, E. N., Landim-Vieira, M., Schaible, N., Lavine, K., et al. (2024) · Journal of Clinical Investigation

Cardiac electrophysiology and arrhythmiasCardiovascular Effects of Exercise

Cited by 32

The Dynamic Role of Cardiac Macrophages in Aging and Disease

Jimenez, J., & Lavine, K. J. (2022) · Current Cardiology Reports

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 15

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

Amrute, J. M., Luo, X., Penna, V., Bredemeyer, A., Yamawaki, T., Heo, G. S., Shi, S., Koenig, A., Yang, S., Kadyrov, F., et al. (2022) · bioRxiv

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 14

Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

Koenig, A. L., Kadyrov, F. F., Amrute, J. M., Yang, S., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Smith, G., & Lavine, K. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 12

Defining Cardiac Recovery at Single Cell Resolution

Amrute, J. M., Lai, L., Ma, P., Koenig, A. L., Kamimoto, K., Bredemeyer, A., Shankar, T. S., Kuppe, C., Kadyrov, F. F., Schulte, L. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 6