New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works

Cell Biology of Ischemia/Reperfusion Injury

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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

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Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

Suntharalingam, G., Perry, M. R., Ward, S., Brett, S. J., Castello-Cortes, A., Brunner, M. D., & Panoskaltsis, N. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa063842 · Cited by 2,164 · see citing works

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure: Results of the Anti-TNF Therapy Against Congestive Heart failure (ATTACH) Trial

Chung, E. S., Packer, M., Lo, K. H., Fasanmade, A. A., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000077913.60364.d2 · Cited by 1,644 · see citing works

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494 · see citing works

Targeted Anticytokine Therapy in Patients With Chronic Heart Failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124490.27666.b2 · Cited by 1,240 · see citing works

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature · doi:10.1038/nature10992 · Cited by 1,201 · see citing works

Macrophages Facilitate Electrical Conduction in the Heart

Hulsmans, M., Clauss, S., Xiao, L., Aguirre, A. D., King, K. R., Hanley, A., Hucker, W. J., Wülfers, E. M., Seemann, G., Courties, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.050 · Cited by 1,011 · see citing works

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., Thuren, T. Y., Glynn, R. J., Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32814-3 · Cited by 943 · see citing works

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

Shiojima, I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24682 · Cited by 935 · see citing works

Self-Renewing Resident Cardiac Macrophages Limit Adverse Remodeling Following Myocardial Infarction

Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0272-2 · Cited by 883 · see citing works

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876 · see citing works

Macrophages are required for neonatal heart regeneration

Aurora, A. B., Porrello, E. R., Tan, W. H., Mahmoud, A. I., Hill, J. A., Bassel‐Duby, R., Sadek, H. A., & Olson, E. N. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72181 · Cited by 823 · see citing works

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406508111 · Cited by 818 · see citing works

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

Bajpai, G., Bredemeyer, A., Li, W., Zaitsev, K., Koenig, A. L., Lokshina, I., Mohan, J., Ivey, B., Hsiao, H.-M., Weinheimer, C., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314028 · Cited by 751 · see citing works

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

Horckmans, M., Ring, L., Duchêne, J., Santovito, D., Schloss, M. J., Drechsler, M. D., Weber, C., Soehnlein, O., & Steffens, S. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw002 · Cited by 737 · see citing works

The human heart contains distinct macrophage subsets with divergent origins and functions

Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0059-x · Cited by 712 · see citing works

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

Weirather, J., Hofmann, U., Beyersdorf, N., Ramos, G. C., Vogel, B., Frey, A., Ertl, G., Kerkau, T., & Frantz, S. (2014) · Circulation Research · doi:10.1161/circresaha.115.303895 · Cited by 705 · see citing works

Chronic Heart Failure and Inflammation

Dick, S. A., & Epelman, S. (2016) · Circulation Research · doi:10.1161/circresaha.116.308030 · Cited by 691 · see citing works

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

Heidt, T., Courties, G., Dutta, P., Sager, H. B., Sebas, M., Iwamoto, Y., Sun, Y., Da Silva, N., Panizzi, P., van der Laan, A. M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.303567 · Cited by 607 · see citing works

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

Kehat, I., & Molkentin, J. D. (2010) · Circulation · doi:10.1161/circulationaha.110.942268 · Cited by 592 · see citing works

IRF3 and type I interferons fuel a fatal response to myocardial infarction

King, K. R., Aguirre, A. D., Ye, Y., Sun, Y., Roh, J. D., Ng, R. P., Köhler, R. H., Arlauckas, S. P., Iwamoto, Y., Savol, A. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4428 · Cited by 571 · see citing works

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Hilgendorf, I., Gerhardt, L. M. S., Tan, T. C., Winter, C., Holderried, T. A. W., Chousterman, B. G., Iwamoto, Y., Liao, R., Zirlik, A., Scherrer‐Crosbie, M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.303204 · Cited by 549 · see citing works

Abandoning M1/M2 for a Network Model of Macrophage Function

Nahrendorf, M., & Swirski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.309194 · Cited by 525 · see citing works

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Li, W., Feng, G., Gauthier, J. M., Lokshina, I., Higashikubo, R., Evans, S., Liu, X., Hassan, A., Tanaka, S., Cicka, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126428 · Cited by 492 · see citing works

Inflammatory Markers and Incident Heart Failure Risk in Older Adults

Kalogeropoulos, A., Georgiopoulou, V., Psaty, B. M., Rodondi, N., Smith, A. L., Harrison, D. G., Liu, Y., Hoffmann, U., Bauer, D. C., Newman, A. B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.045 · Cited by 478 · see citing works

Activation of CD4 + T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice

Hofmann, U., Beyersdorf, N., Weirather, J., Podolskaya, A., Bauersachs, J. K., Ertl, G., Kerkau, T., & Frantz, S. (2012) · Circulation · doi:10.1161/circulationaha.111.044164 · Cited by 478 · see citing works

Angiogenesis and Cardiac Hypertrophy

Oka, T., Akazawa, H., Naito, A. T., & Komuro, I. (2014) · Circulation Research · doi:10.1161/circresaha.114.300507 · Cited by 461 · see citing works

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

Uderhardt, S., Martins, A. J., Tsang, J. S., Lämmermann, T., & Germain, R. N. (2019) · Cell · doi:10.1016/j.cell.2019.02.028 · Cited by 383 · see citing works

Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure

Sager, H., Hulsmans, M., Lavine, K. J., Moreira, M. B., Heidt, T., Courties, G., Sun, Y., Iwamoto, Y., Tricot, B., Khan, O. F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309001 · Cited by 377 · see citing works

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3343 · Cited by 372 · see citing works

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Yang, W., Tao, Y., Wu, Y., Zhao, X., Ye, W., Zhao, D., Fu, L., Tian, C., Yang, J., He, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09046-8 · Cited by 367 · see citing works

Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure

Ismahil, M. A., Hamid, T., Bansal, S. S., Patel, B., Kingery, J. R., & Prabhu, S. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.301720 · Cited by 340 · see citing works

Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage

Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.-K., Fischer, R., Schwarz, I., Rahn, H.-P., Plehm, R., Wellner, M., Elitok, S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.832782 · Cited by 336 · see citing works

Primitive Embryonic Macrophages are Required for Coronary Development and Maturation

Leid, J. M., Carrelha, J., Boukarabila, H., Epelman, S., Jacobsen, S. E. W., & Lavine, K. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.308270 · Cited by 327 · see citing works

An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile

Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W., & Rosenthal, N. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036814 · Cited by 318 · see citing works

Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling

Anzai, A., Anzai, T., Nagai, S., Maekawa, Y., Naito, K., Kaneko, H., Sugano, Y., Takahashi, T., Abe, H., Mochizuki, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.052126 · Cited by 313 · see citing works

Mapping macrophage polarization over the myocardial infarction time continuum

Mouton, A. J., DeLeon‐Pennell, K. Y., Gonzalez, O. J. R., Flynn, E. R., Freeman, T. C., Saucerman, J. J., Garrett, M. R., Ma, Y., Harmancey, R., & Lindsey, M. L. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0686-x · Cited by 307 · see citing works

CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

Dobaczewski, M., Xia, Y., Bujak, M., Gonzalez-Quesada, C., & Frangogiannis, N. G. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090759 · Cited by 301 · see citing works

CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload

Patel, B., Bansal, S. S., Ismahil, M. A., Hamid, T., Rokosh, G., Mack, M., & Prabhu, S. D. (2018) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2017.12.006 · Cited by 297 · see citing works

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

Laroumanie, F., Douin‐Echinard, V., Pozzo, J., Lairez, O., Tortosa, F., Vinel, C., Delage, C., Calise, D., Dutaur, M., Parini, A., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007101 · Cited by 294 · see citing works

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

Majmudar, M. D., Keliher, E. J., Heidt, T., Leuschner, F., Truelove, J. J., Sena, B. F., Gorbatov, R., Iwamoto, Y., Dutta, P., Wojtkiewicz, G. R., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000116 · Cited by 289 · see citing works

Myocardial Infarct–Sparing Effect of Adenosine A 2A Receptor Activation Is due to Its Action on CD4 + T Lymphocytes

Yang, Z., Day, Y., Toufektsian, M.-C., Xu, Y., Ramos, S. I., Marshall, M. A., French, B. A., & Linden, J. M. (2006) · Circulation · doi:10.1161/circulationaha.106.649244 · Cited by 286 · see citing works

Tissue macrophage identity and self‐renewal

Gentek, R., Molawi, K., & Sieweke, M. H. (2014) · Immunological Reviews · doi:10.1111/imr.12224 · Cited by 277 · see citing works

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure

Nevers, T. A., Salvador, A. M., Grodecki‐Pena, A., Knapp, A., Velázquez, F., Aronovitz, M. J., Kapur, N. K., Karas, R. H., Blanton, R. M., & Alcaide, P. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002225 · Cited by 272 · see citing works

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

Cao, D. J., Schiattarella, G. G., Villalobos, E., Jiang, N., May, H. I., Li, T., Chen, Z. J., Gillette, T. G., & Hill, J. A. (2018) · Circulation · doi:10.1161/circulationaha.117.031046 · Cited by 272 · see citing works

Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events

Emami, H., Singh, P., MacNabb, M. H., Vucic, E., Lavender, Z. R., Rudd, J. H. F., Fayad, Z. A., Lehrer‐Graiwer, J., Korsgren, M., Figueroa, A. L., et al. (2015) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.10.009 · Cited by 264 · see citing works

The Macrophage in Cardiac Homeostasis and Disease

Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2149 · Cited by 234 · see citing works

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis

Moore, K. J., Koplev, S., Fisher, E. A. A., Tabas, I. A., Björkegren, J., Doran, A. C., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2147 · Cited by 221 · see citing works

Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells

Dutta, P., Sager, H. B., Stengel, K. R., Naxerova, K., Courties, G., Sáez, B., Silberstein, L., Heidt, T., Sebas, M., Sun, Y., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.04.008 · Cited by 219 · see citing works

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

Varga, T., Mounier, R., Horváth, A., Cuvellier, S., Dumont, F., Póliska, S., Ardjoune, H., Juban, G., Nagy, L., & Chazaud, B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502490 · Cited by 218 · see citing works

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

Anzai, A., Choi, J. L., He, S., Fenn, A. M., Nairz, M., Rattik, S., McAlpine, C. S., Mindur, J. E., Chan, C. T., Iwamoto, Y., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170689 · Cited by 210 · see citing works

Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non–ST-Segment Elevation Myocardial Infarction

Tardif, J., Tanguay, J., Wright, S. R., Duchatelle, V., Petroni, T., Grégoire, J. C., Ibrahim, R., Heinonen, T. M., Robb, S., Bertrand, O. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.003 · Cited by 206 · see citing works

Targeted Deletion of CC Chemokine Receptor 2 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction

Kaikita, K., Hayasaki, T., Okuma, T., Kuziel, W. A., Ogawa, H., & Takeya, M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63309-3 · Cited by 206 · see citing works

Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution?

Puhl, S., & Steffens, S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00025 · Cited by 197 · see citing works

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 192 · see citing works

Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

Liao, X., Shen, Y., Zhang, R., Sugi, K., Vasudevan, N. T., Alaiti, M. A., Sweet, D. R., Zhou, L., Qing, Y., Gerson, S. L., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720065115 · Cited by 185 · see citing works

Infarcted Myocardium-Primed Dendritic Cells Improve Remodeling and Cardiac Function After Myocardial Infarction by Modulating the Regulatory T Cell and Macrophage Polarization

Choo, E., Lee, J.-H., Park, E., Park, H., Jung, N.-C., Kim, T., Koh, Y., Kim, E., Seung, K., Park, C., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.023106 · Cited by 173 · see citing works

Myocardial aging as a T-cell–mediated phenomenon

Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621047114 · Cited by 168 · see citing works

Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor

HoWangYin, K.-Y., Zlatanova, I., Pinto, C., Ngkelo, A., Cochain, C., Rouanet, M., Vilar, J., Lemitre, M., Stockmann, C., Fleischmann, B. K., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.020857 · Cited by 165 · see citing works

Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling

Li, W., Hsiao, H.-M., Higashikubo, R., Saunders, B. T., Bharat, A., Goldstein, D. R., Krupnick, A. S., Gelman, A. E., Lavine, K. J., & Kreisel, D. (2016) · JCI Insight · doi:10.1172/jci.insight.87315 · Cited by 162 · see citing works

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Nakayama, H., & Otsu, K. (2018) · Biochemical Journal · doi:10.1042/bcj20170714 · Cited by 160 · see citing works

Cross-talk between macrophages and atrial myocytes in atrial fibrillation

Sun, Z., Zhou, D., Xie, X., Wang, S., Wang, Z., Zhao, W., Xu, H., & Zheng, L. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0584-z · Cited by 153 · see citing works

Exaggerated Inflammation and Monocytosis Associate With Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction: Evidence of M2 Macrophage Activation in Disease Pathogenesis

Glezeva, N., Voon, V., Watson, C. J., Horgan, S. J., McDonald, K., Ledwidge, M. T., & Baugh, J. A. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.11.004 · Cited by 152 · see citing works

Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways

Honsho, S., Nishikawa, S., Amano, K., Zen, K., Adachi, Y., Kishita, E., Matsui, A., Katsume, A., Yamaguchi, S., Nishikawa, K., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.208199 · Cited by 146 · see citing works

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction

DuBrock, H. M., AbouEzzeddine, O. F., & Redfield, M. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201836 · Cited by 144 · see citing works

Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease

Williams, J. W., Giannarelli, C., Rahman, A. H., Randolph, G. J., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2148 · Cited by 142 · see citing works

Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation

Wang, L., Li, Y., Zhang, C., Cui, W., Xia, W., Xia, Y., Du, J., & Li, H. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt258 · Cited by 134 · see citing works

Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart

Heo, G. S., Kopecky, B. J., Sultan, D. H., Ou, M., Feng, G., Bajpai, G., Zhang, X., Luehmann, H. P., Detering, L., Su, Y., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314030 · Cited by 131 · see citing works

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

Volz, H. C., Laohachewin, D., Seidel, C., Lasitschka, F., Keilbach, K., Wienbrandt, A. R., Andrassy, J., Bierhaus, A., Kaya, Z., Katus, H. A., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0250-z · Cited by 130 · see citing works

Relationship Between Central Sympathetic Drive and Magnetic Resonance Imaging–Determined Left Ventricular Mass in Essential Hypertension

Burns, J., Sivananthan, M. U., Ball, S. G., Mackintosh, A. F., Mary, D. A. S. G., & Greenwood, J. P. (2007) · Circulation · doi:10.1161/circulationaha.106.668863 · Cited by 122 · cited 1× · see citing works

Regulatory T Lymphocytes Attenuate Myocardial Infarction-Induced Ventricular Remodeling in Mice

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Inflammatory cytokines as biomarkers in heart failure

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β 2 -Adrenergic receptor disruption exacerbates cardiac injury and fibroblast activation in a female mouse model of Takotsubo cardiomyopathy

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Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure

Li, X., Shao, M., Liu, Z., Sun, X., Cui, L., Liu, X., Wang, G., Lu, L., Wu, Y. L., & Li, C. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9024394 · Cited by 1 · see citing works

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory functionPreprint

Dueck, A., Althaus, L., Heise, K., Esfandyari, D., Baygün, S., Brandes, R. P., Gagneur, J., Jaé, N., Knolle, P. A., Leisegang, M. S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.30.518576 · Cited by 1 · see citing works

SupErbB monocytes? Innate immune cells help the heart adapt

Vagnozzi, R. J. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.12.003

Joint Application of Multiple Inflammatory Cytokines in Development of Heart FailurePreprint

Yu, M., Zhang, Q., Zhu, J., Xu, L., Chen, L., & Zheng, K. (2023) · Research Square · doi:10.21203/rs.3.rs-3333525/v1

Ventricular remodelling

Dı́ez, J., & Rocca, H. B. (2023) · doi:10.1093/med/9780198891628.003.0022

Immunometabolic regulation of cardiac macrophages in heart failure with preserved ejection fraction

Liang, J., Su, M., Liu, R., Li, T., Qin, Z., & Wáng, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1896936

Inflammatory Biomarkers and Left Atrial Remodelling for Early Risk Stratification of 6-Month Readmission in Ischaemic and Idiopathic Dilated Cardiomyopathy

Vladutu, C.-V., Țieranu, E., Rocșoreanu, A., Militaru, C., Militaru, S., & Neagoe, C. (2026) · Medicina · doi:10.3390/medicina62101884

Monocyte and macrophage subsets along the continuum to heart failure: Misguided heroes or targetable villains?

Glezeva, N., Horgan, S. J., & Baugh, J. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.10.029 · Cited by 61 · see citing works

Emerging roles of macrophages in heart failure and associated treatment approaches

Xie, L., Chen, J., Wang, Y., Jin, C., Xie, Y., Ma, H., & Xiang, M. (2023) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223231168755 · Cited by 16 · see citing works

Cardiac macrophages and their functions in homeostasis and injury

Trimaglio, G., Mirtschink, P., El‐Armouche, A., & Chavakis, T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120480 · Cited by 1 · see citing works

Monocyte and macrophage contributions to cardiac remodeling

Hulsmans, M., Sam, F., & Nahrendorf, M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.015 · Cited by 279 · see citing works

Macrophages in ventricular remodeling and heart failure: orchestrators of inflammation and repair

Han, F., Hu, W., Liu, Y., Xu, X., Zhou, P., Qu, C., & Liu, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682294 · Cited by 19 · see citing works