Thorne, Robert G.

Intranasal delivery of biologics to the central nervous system

Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews

Advanced Drug Delivery SystemsBarrier Structure and Function Studies

Cited by 1,214

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience

Advanced Drug Delivery SystemsBarrier Structure and Function Studies

Cited by 958

In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space

Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesOptical Imaging and Spectroscopy Techniques

Cited by 641

Delivery of Neurotrophic Factors to the Central Nervous System: Pharmacokinetic Considerations

Thorne, R. G., & Frey, W. H. (2001) · Clinical Pharmacokinetics

Barrier Structure and Function StudiesAdvanced Drug Delivery Systems

Cited by 487

Quantitative analysis of the olfactory pathway for drug delivery to the brain

Thorne, R. G., Emory, C. R., Ala, T. A., & Frey, W. H. (1995) · Brain Research

Advanced Drug Delivery SystemsOlfactory and Sensory Function Studies

Cited by 352

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

Wolak, D. J., & Thorne, R. G. (2013) · Molecular Pharmaceutics

Barrier Structure and Function StudiesNanoparticle-Based Drug Delivery

Cited by 299

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

Pizzo, M. E., Wolak, D. J., Kumar, N. N., Brunette, E., Brunnquell, C. L., Hannocks, M., Abbott, N. J., Meyerand, M. E., Sorokin, L., Stanimirovic, D. B., et al. (2018) · The Journal of Physiology

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 272

Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

Ross, T. M., Martinez, P. M., Renner, J. C., Thorne, R. G., Hanson, L. R., & Frey, W. H. (2004) · Journal of Neuroimmunology

Advanced Drug Delivery SystemsMultiple Sclerosis Research Studies

Cited by 242

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich, B., Zhan, L., Xia, D., Chan, D., Joy, D., Park, J. I., Tatarakis, D., Calvert, M., Hummel, S., Lianoglou, S., et al. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 233

Brain delivery and activity of a lysosomal enzyme using a blood–brain barrier transport vehicle in mice

Ullman, J. C., Arguello, A., Getz, J. A., Bhalla, A., Mahon, C. S., Wang, J., Giese, T., Bedard, C., Kim, D. J., Blumenfeld, J. R., et al. (2020) · Science Translational Medicine

Lysosomal Storage Disorders ResearchBarrier Structure and Function Studies

Cited by 205

Molecular characterization of perivascular drainage pathways in the murine brain

Hannocks, M.-J., Pizzo, M. E., Huppert, J., Deshpande, T., Abbott, N. J., Thorne, R. G., & Sorokin, L. (2018) · Journal of Cerebral Blood Flow & Metabolism

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 201

Diffusion of Epidermal Growth Factor in Rat Brain Extracellular Space Measured by Integrative Optical Imaging

Thorne, R. G., Hrabětová, S., & Nicholson, C. (2004) · Journal of Neurophysiology

Optical Imaging and Spectroscopy TechniquesBarrier Structure and Function Studies

Cited by 168

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

Barker, S. J., Thayer, M. B., Kim, C., Tatarakis, D., Simon, M. J., Dial, R., Nilewski, L., Wells, R. C., Zhou, Y., Afetian, M., et al. (2024) · Science Translational Medicine

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 142

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Xia, D., Lianoglou, S., Sandmann, T., Calvert, M., Suh, J. H., Thomsen, E., Dugas, J., Pizzo, M. E., DeVos, S. L., Earr, T. K., et al. (2022) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 124

Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.

Pizzo, M. E., Plowey, E. D., Khoury, N., Kwan, W., Abettan, J., DeVos, S. L., Discenza, C. B., Earr, T., Joy, D., Lye-Barthel, M., et al. (2025) · Science

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 63

The Extracellular and Perivascular Spaces of the Brain

Pizzo, M. E., & Thorne, R. G. (2017) · Brain Edema

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 15