Kalluri, Raghu

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors

De Raedt, T., Walton, Z., Yecies, J. L., Li, D., Chen, Y., Malone, C. F., Maertens, O., Jeong, S. M., Bronson, R. T., Lebleu, V., et al. (2011) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingEndoplasmic Reticulum Stress and Disease

Cited by 258

KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

Mahadevan, K. K., McAndrews, K. M., LeBleu, V. S., Yang, S., Lyu, H., Li, B., Sockwell, A. M., Kirtley, M. L., Morse, S. J., Moreno Diaz, B. A., et al. (2023) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Immunotherapy and Biomarkers

Cited by 258

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Yang, S., Che, S. P. Y., Kurywchak, P., Tavormina, J. L., Gansmo, L. B., Correa de Sampaio, P., Tachezy, M., Bockhorn, M., Gebauer, F., Haltom, A. R., et al. (2017) · Cancer Biology & Therapy

Extracellular vesicles in diseaseCancer Genomics and Diagnostics

Cited by 248

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases

Cited by 245

Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis

Schweitzer, M. H., Zheng, W., Organ, C. L., Avci, R., Suo, Z., Freimark, L. M., Lebleu, V. S., Duncan, M. B., Vander Heiden, M. G., Neveu, J. M., et al. (2009) · Science

Paleontology and Evolutionary BiologyEvolution and Paleontology Studies

Cited by 238

Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras G12D in pancreatic cancer

McAndrews, K. M., Xiao, F., Chronopoulos, A., LeBleu, V. S., Kugeratski, F. G., & Kalluri, R. (2021) · Life Science Alliance

Extracellular vesicles in diseaseCRISPR and Genetic Engineering

Cited by 216

αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

Hahm, K., Lukashev, M. E., Luo, Y., Yang, W. J., Dolinski, B. M., Weinreb, P. H., Simon, K. J., Chun Wang, L., Leone, D. R., Lobb, R. R., et al. (2007) · The American Journal of Pathology

Renal Diseases and GlomerulopathiesCell Adhesion Molecules Research

Cited by 190

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

Léveillé, N., Melo, C. A., Rooijers, K., Díaz-Lagares, A., Melo, S. A., Korkmaz, G., Lopes, R., Moqadam, F. A., Maia, A. R., Wijchers, P. J., et al. (2015) · Nature Communications

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 183

Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2

Keskin, D., Kim, J., Cooke, V. G., Wu, C.-C., Sugimoto, H., Gu, C., De Palma, M., Kalluri, R., & LeBleu, V. S. (2015) · Cell Reports

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 165

Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Hou, P., Kapoor, A., Zhang, Q., Li, J., Wu, C.-J., Li, J., Lan, Z., Tang, M., Ma, X., Ackroyd, J. J., et al. (2020) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchImmune cells in cancer

Cited by 154

Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta

Chen, Y., Yang, S., Lovisa, S., Ambrose, C. G., McAndrews, K. M., Sugimoto, H., & Kalluri, R. (2021) · Nature Communications

Connective tissue disorders researchBone Metabolism and Diseases

Cited by 134

Engineered exosomes with KrasG12D specific siRNA in pancreatic cancer: a phase I study with immunological correlates

Kalluri, V. S., Smaglo, B. G., Mahadevan, K. K., Kirtley, M. L., McAndrews, K. M., Mendt, M., Yang, S., Maldonado, A. S., Sugimoto, H., Salvatierra, M. E., et al. (2025) · Nature Communications

Extracellular vesicles in diseaseRNA Interference and Gene Delivery

Cited by 70

Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure

Tampe, B., Tampe, D., Nyamsuren, G., Klöpper, F., Rapp, G., Kauffels, A., Lorf, T., Zeisberg, E. M., Müller, G. A., Kalluri, R., et al. (2018) · Journal of Clinical Investigation

TGF-β signaling in diseasesChronic Kidney Disease and Diabetes

Cited by 24