Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
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Sonic hedgehog inhibition to inactivate CAFs failed in patients, and later preclinical studies identified explanations for that failure.
“Subsequently, attempts to inactivate CAFs through sonic hedgehog inhibition proved ineffective in patients289, and preclinical studies that were conducted after the fact pinpointed reasons for this failure159,290.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [289]
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- Authors
- Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., De Jesus-Acosta, A., Sharma, P., Heidari, P., Mahmood, U., Chin, L., Moses, H. L., Weaver, V. M., Maitra, A., Allison, J. P., LeBleu, V. S., & Kalluri, R.
- Corresponding author
- Kalluri, Raghu
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 28
- Issue
- 6
- Pages
- 831-833
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2462485532
- Cited by
- 245
- References
- 0
- Citations by year
- 2026: 27 · 2025: 21 · 2024: 35 · 2023: 25 · 2022: 26 · 2021: 36 · 2020: 34 · 2019: 20 · 2018: 14 · 2017: 4 · 2016: 1 · 2015: 2
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- Funders
- National Cancer Institute (U01CA151925)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- cancer-associated fibroblasts, pancreatic ductal adenocarcinoma, tumor fibrosis, myofibroblasts, immunosuppression, gemcitabine, patient survival, tumor microenvironment
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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