Uhr, Manfred

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry

Genetic Associations and EpidemiologyBipolar Disorder and Treatment

Cited by 1,120

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 977

The Role of m6A/m-RNA Methylation in Stress Response Regulation

Engel, M., Eggert, C., Kaplick, P. M., Eder, M., Röh, S., Tietze, L., Namendorf, C., Arloth, J., Weber, P., Rex-Haffner, M., et al. (2018) · Neuron

RNA modifications and cancerRNA regulation and disease

Cited by 411

Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression

Zobel, A. W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., & Ising, M. (2001) · Journal of Psychiatric Research

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 354

Combined Dexamethasone/Corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression–A Potential Biomarker?

Ising, M., Horstmann, S., Kloiber, S., Lucae, S., Binder, E. B., Kern, N., Künzel, H. E., Pfennig, A., Uhr, M., & Holsboer, F. (2007) · Biological Psychiatry

Stress Responses and CortisolTreatment of Major Depression

Cited by 341

Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study

Zimmermann, P., Brückl, T., Nocon, A., Pfister, H., Binder, E. B., Uhr, M., Lieb, R., Moffitt, T. E., Caspi, A., Holsboer, F., et al. (2011) · American Journal of Psychiatry

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 262

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics

Adenosine and Purinergic SignalingGenetic Associations and Epidemiology

Cited by 261

Selective inhibitors of the FK506-binding protein 51 by induced fit

Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Fernandez-Vizarra, P., Sippel, C., Zannas, A. S., et al. (2015) · Nature Chemical Biology

Signaling Pathways in DiseaseTreatment of Major Depression

Cited by 245

The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression

Kohli, M. A., Lucae, S., Saemann, P. G., Schmidt, M. V., Demirkan, A., Hek, K., Czamara, D., Alexander, M., Salyakina, D., Ripke, S., et al. (2011) · Neuron

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 228

Prevalence of anterior pituitary insufficiency 3 and 12 months after traumatic brain injury

Schneider, H. J., Schneider, M., Saller, B., Petersenn, S., Uhr, M., Husemann, B., von Rosen, F., & Stalla, G. K. (2006) · European Journal of Endocrinology

Pituitary Gland Disorders and TreatmentsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 224

Sleep enhances nocturnal plasma ghrelin levels in healthy subjects

Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Sleep and Wakefulness ResearchRegulation of Appetite and Obesity

Cited by 184

Ghrelin Stimulates Appetite, Imagination of Food, GH, ACTH, and Cortisol, but does not Affect Leptin in Normal Controls

Schmid, D. A., Held, K., Ising, M., Uhr, M., Weikel, J. C., & Steiger, A. (2005) · Neuropsychopharmacology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 181

Depression, comorbidities and the TNF-α system

Himmerich, H., Fulda, S., Linseisen, J., Seiler, H., Wolfram, G., Himmerich, S., Gedrich, K., Kloiber, S., Lucae, S., Ising, M., et al. (2008) · European Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 181

Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients

Menke, A., Arloth, J., Pütz, B., Weber, P., Klengel, T., Mehta, D., Gonik, M., Rex-Haffner, M., Rubel, J., Uhr, M., et al. (2012) · Neuropsychopharmacology

Stress Responses and CortisolTreatment of Major Depression

Cited by 177

Changes of Sleep Architecture, Spectral Composition of Sleep EEG, the Nocturnal Secretion of Cortisol, ACTH, GH, Prolactin, Melatonin, Ghrelin, and Leptin, and the DEX-CRH Test in Depressed Patients during Treatment with Mirtazapine

Schmid, D. A., Wichniak, A., Uhr, M., Ising, M., Brunner, H., Held, K., Weikel, J. C., Sonntag, A., & Steiger, A. (2006) · Neuropsychopharmacology

Stress Responses and CortisolSleep and Wakefulness Research

Cited by 165

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression

Menke, A., Klengel, T., Rubel, J., Brückl, T., Pfister, H., Lucae, S., Uhr, M., Holsboer, F., & Binder, E. B. (2013) · Genes, Brain and Behavior

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 151

Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks

Sarapas, C., Cai, G., Bierer, L. M., Golier, J. A., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Uhr, M., et al. (2011) · Disease Markers

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 143

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

Balsevich, G., Häusl, A. S., Meyer, C. W., Karamihalev, S., Feng, X., Pöhlmann, M. L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., et al. (2017) · Nature Communications

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 134

Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties

Hartmann, J., Wagner, K. V., Gaali, S., Kirschner, A., Kozany, C., Ruhter, G., Dedic, N., Hausl, A. S., Hoeijmakers, L., Westerholz, S., et al. (2015) · Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 109

Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

Zaba, M., Kirmeier, T., Ionescu, I. A., Wollweber, B., Buell, D. R., Gall-Kleebach, D. J., Schubert, C. F., Novak, B., Huber, C., Köhler, K., et al. (2015) · Psychoneuroendocrinology

Stress Responses and CortisolPosttraumatic Stress Disorder Research

Cited by 101

Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

Hellmann-Regen, J., Clemens, V., Grözinger, M., Kornhuber, J., Reif, A., Prvulovic, D., Goya-Maldonado, R., Wiltfang, J., Gruber, O., Schüle, C., et al. (2022) · JAMA Network Open

Treatment of Major DepressionTryptophan and brain disorders

Cited by 100

Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

Schmidt, M. V., Trümbach, D., Weber, P., Wagner, K., Scharf, S. H., Liebl, C., Datson, N., Namendorf, C., Gerlach, T., Kühne, C., et al. (2010) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 91

The brain as immunoprecipitator of serum autoantibodies against N‐Methyl‐D‐aspartate receptor subunit NR1

Castillo‐Gomez, E., Kästner, A., Steiner, J., Schneider, A., Hettling, B., Poggi, G., Ostehr, K., Uhr, M., Asif, A. R., Matzke, M., et al. (2016) · Annals of Neurology

Autoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus Research

Cited by 89

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., et al. (2015) · Molecular Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 84