Ingber, Donald E.

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 4,250

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 3,305

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 2,057

Induction of angiogenesis during the transition from hyperplasia to neoplasia

Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989) · Nature

Angiogenesis and VEGF in CancerPancreatic function and diabetes

Cited by 1,879

From 3D cell culture to organs-on-chips

Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 1,834

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 1,734

Cellular mechanotransduction: putting all the pieces together again

Ingber, D. E. (2006) · The FASEB Journal

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 1,627

Human organs-on-chips for disease modelling, drug development and personalized medicine

Ingber, D. E. (2022) · Nature Reviews Genetics

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 1,589

Engineering cell shape and function

Singhvi, R., Kumar, A., Lopez, G. P., Stephanopoulos, G. N., Wang, D. I. C., Whitesides, G. M., & Ingber, D. E. (1994) · Science

Cellular Mechanics and InteractionsNanofabrication and Lithography Techniques

Cited by 1,453

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 993

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 922

Modelling cancer in microfluidic human organs-on-chips

Sontheimer-Phelps, A., Hassell, B. A., & Ingber, D. E. (2019) · Nature Reviews Cancer

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 906

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Jalili-Firoozinezhad, S., Gazzaniga, F. S., Calamari, E. L., Camacho, D. M., Fadel, C. W., Bein, A., Swenor, B., Nestor, B., Cronce, M. J., Tovaglieri, A., et al. (2019) · Nature Biomedical Engineering

Gut microbiota and health3D Printing in Biomedical Research

Cited by 855

Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network

Huang, S., Eichler, G., Bar-Yam, Y., & Ingber, D. E. (2005) · Physical Review Letters

Gene Regulatory Network AnalysisDevelopmental Biology and Gene Regulation

Cited by 775

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Kasendra, M., Tovaglieri, A., Sontheimer-Phelps, A., Jalili-Firoozinezhad, S., Bein, A., Chalkiadaki, A., Scholl, W., Zhang, C., Rickner, H., Richmond, C. A., et al. (2018) · Scientific Reports

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 754

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 750

Microfabrication of human organs-on-chips

Huh, D., Kim, H. J., Fraser, J. P., Shea, D. E., Khan, M., Bahinski, A., Hamilton, G. A., & Ingber, D. E. (2013) · Nature Protocols

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 712

Microfluidic Organ-on-a-Chip Models of Human Intestine

Bein, A., Shin, W., Jalili-Firoozinezhad, S., Park, M. H., Sontheimer-Phelps, A., Tovaglieri, A., Chalkiadaki, A., Kim, H. J., & Ingber, D. E. (2018) · Cellular and Molecular Gastroenterology and Hepatology

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 625

Engineered In Vitro Disease Models

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 554

Reproducing human and cross-species drug toxicities using a liver-chip

Jang, K.-J., Otieno, M. A., Ronxhi, J., Lim, H.-K., Ewart, L., Kodella, K. R., Petropolis, D. B., Kulkarni, G., Rubins, J. E., Conegliano, D., et al. (2019) · Science Translational Medicine

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 511

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

Henry, O. Y. F., Villenave, R., Cronce, M. J., Leineweber, W. D., Benz, M. A., & Ingber, D. E. (2017) · Lab on a Chip

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 482

Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro

Hassell, B. A., Goyal, G., Lee, E., Sontheimer-Phelps, A., Levy, O., Chen, C. S., & Ingber, D. E. (2017) · Cell Reports

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 467

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering

3D Printing in Biomedical ResearchSARS-CoV-2 and COVID-19 Research

Cited by 440

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

Ewart, L., Apostolou, A., Briggs, S. A., Carman, C. V., Chaff, J. T., Heng, A. R., Jadalannagari, S., Janardhanan, J., Jang, K.-J., Joshipura, S. R., et al. (2022) · Communications Medicine

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 337