Farooqi, I. Sadaf

20 YEARS OF LEPTIN: Human disorders of leptin action

Farooqi, I. S., & O'Rahilly, S. (2014) · Journal of Endocrinology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 280

Congenital Leptin Deficiency Due to Homozygosity for the Δ133G Mutation: Report of Another Case and Evaluation of Response to Four Years of Leptin Therapy

Gibson, W. T., Farooqi, I. S., Moreau, M., DePaoli, A. M., Lawrence, E., O’Rahilly, S., & Trussell, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 275

Hyperphagia and Early-Onset Obesity due to a Novel Homozygous Missense Mutation in Prohormone Convertase 1/3

Farooqi, I. S., Volders, K., Stanhope, R., Heuschkel, R., White, A., Lank, E., Keogh, J., O’Rahilly, S., & Creemers, J. W. M. (2007) · The Journal of Clinical Endocrinology & Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 218

Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions

O'Rahilly, S., & Farooqi, I. S. (2008) · Diabetes

Regulation of Appetite and ObesityEating Disorders and Behaviors

Cited by 205

High protein intake stimulates postprandial GLP1 and PYY release

van der Klaauw, A. A., Keogh, J. M., Henning, E., Trowse, V. M., Dhillo, W. S., Ghatei, M. A., & Farooqi, I. S. (2013) · Obesity

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 175

Obesity due to Melanocortin 4 Receptor (MC4R) Deficiency Is Associated with Increased Linear Growth and Final Height, Fasting Hyperinsulinemia, and Incompletely Suppressed Growth Hormone Secretion

Martinelli, C. E., Keogh, J. M., Greenfield, J. R., Henning, E., van der Klaauw, A. A., Blackwood, A., O'Rahilly, S., Roelfsema, F., Camacho-Hübner, C., Pijl, H., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Growth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

Cited by 153

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Wade, K. H., Lam, B. Y. H., Melvin, A., Pan, W., Corbin, L. J., Hughes, D. A., Rainbow, K., Chen, J.-H., Duckett, K., Liu, X., et al. (2021) · Nature Medicine

Regulation of Appetite and ObesityGenetic Associations and Epidemiology

Cited by 133

Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity

Rubino, F., Batterham, R. L., Koch, M., Mingrone, G., le Roux, C. W., Farooqi, I. S., Farpour-Lambert, N., Gregg, E. W., & Cummings, D. E. (2023) · The Lancet Diabetes & Endocrinology

Obesity and Health PracticesObesity, Physical Activity, Diet

Cited by 126

Prolonged Successful Therapy for Hyperinsulinaemic Hypoglycaemia after Gastric Bypass: The Pathophysiological Role of GLP1 and Its Response to a Somatostatin Analogue

Myint, K. S., Greenfield, J. R., Farooqi, I. S., Henning, E., Holst, J. J., & Finer, N. (2012) · European Journal of Endocrinology

Bariatric Surgery and OutcomesPancreatic function and diabetes

Cited by 77

Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism

von Schnurbein, J., Moss, A., Nagel, S. A., Muehleder, H., Debatin, K. M., Farooqi, I. S., & Wabitsch, M. (2012) · Hormone Research in Paediatrics

Hypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

Cited by 70

Energy expenditure in frontotemporal dementia: a behavioural and imaging study

Ahmed, R. M., Landin-Romero, R., Collet, T.-H., van der Klaauw, A. A., Devenney, E., Henning, E., Kiernan, M. C., Piguet, O., Farooqi, I. S., & Hodges, J. R. (2017) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 58

Hypothalamic obesity: from basic mechanisms to clinical perspectives

Argente, J., Farooqi, I. S., Chowen, J. A., Kühnen, P., López, M., Morselli, E., Gan, H.-W., Spoudeas, H. A., Wabitsch, M., & Tena-Sempere, M. (2025) · The Lancet Diabetes & Endocrinology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 57

Setmelanotide in patients aged 2–5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial

Argente, J., Verge, C. F., Okorie, U., Fennoy, I., Kelsey, M. M., Cokkinias, C., Scimia, C., Lee, H.-M., & Farooqi, I. S. (2025) · The Lancet Diabetes & Endocrinology

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 55

A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism

Koulouri, O., Nicholas, A. K., Schoenmakers, E., Mokrosinski, J., Lane, F., Cole, T., Kirk, J., Farooqi, I. S., Chatterjee, V. K., Gurnell, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 32

Tirzepatide leads to weight reduction in people with obesity due to MC4R deficiency

Bhatnagar, P., Ahmad, N. N., Li, X., Coghlan, M., Kaplan, L. M., & Farooqi, I. S. (2025) · Nature Medicine

Pharmacology and Obesity TreatmentRegulation of Appetite and Obesity

Cited by 20

Early childhood height, weight, and BMI development in children with monogenic obesity: a European multicentre, retrospective, observational study

Zorn, S., de Groot, C. J., Brandt-Heunemann, S., von Schnurbein, J., Abawi, O., Bounds, R., Ruck, L., Guijo, B., Martos-Moreno, G. Á., Nicaise, C., et al. (2025) · The Lancet Child & Adolescent Health

Regulation of Appetite and ObesityGenomics and Rare Diseases

Cited by 19

Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature

Ahmed, R. M., Tse, N. Y., Chen, Y., Henning, E., Hodges, J. R., Kiernan, M. C., Irish, M., Farooqi, I. S., & Piguet, O. (2021) · Annals of Clinical and Translational Neurology

Dementia and Cognitive Impairment ResearchEating Disorders and Behaviors

Cited by 12

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

Baird, H. J. M., Shun-Shion, A. S., Mendes de Oliveira, E., Stalder, D., Liang, L., Eden, J., Chambers, J. E., Farooqi, I. S., Gershlick, D. C., & Fazakerley, D. J. (2024) · Journal of Biological Chemistry

Regulation of Appetite and ObesityCellular transport and secretion

Cited by 0