Energy expenditure in frontotemporal dementia: a behavioural and imaging study
Open accessAbstract
SEE FINGER DOI101093/AWW312 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Abnormal eating behaviour and metabolic parameters including insulin resistance, dyslipidaemia and body mass index are increasingly recognized as important components of neurodegenerative disease and may contribute to survival. It has previously been established that behavioural variant frontotemporal dementia is associated with abnormal eating behaviour characterized by increased sweet preference. In this study, it was hypothesized that behavioural variant frontotemporal dementia might also be associated with altered energy expenditure. A cohort of 19 patients with behavioural variant frontotemporal dementia, 13 with Alzheimer's disease and 16 (age- and sex-matched) healthy control subjects were studied using Actiheart devices (CamNtech) to assess resting and stressed heart rate. Actiheart devices were fitted for 7 days to measure sleeping heart rate, activity levels, and resting, active and total energy expenditure. Using high resolution structural magnetic resonance imaging the neural correlates of increased resting heart rate were investigated including cortical thickness and region of interest analyses. In behavioural variant frontotemporal dementia, resting (P = 0.001), stressed (P = 0.037) and sleeping heart rate (P = 0.038) were increased compared to control subjects, and resting heart rate (P = 0.020) compared to Alzheimer disease patients. Behavioural variant frontotemporal dementia was associated with decreased activity levels compared to controls (P = 0.002) and increased resting energy expenditure (P = 0.045) and total energy expenditure (P = 0.035). Increased resting heart rate correlated with behavioural (Cambridge Behavioural Inventory) and cognitive measures (Addenbrooke's Cognitive Examination). Increased resting heart rate in behavioural variant frontotemporal dementia correlated with atrophy involving the mesial temporal cortex, insula, and amygdala, regions previously suggested to be involved exclusively in social and emotion processing in frontotemporal dementia. These neural correlates overlap the network involved in eating behaviour in frontotemporal dementia, suggesting a complex interaction between eating behaviour, autonomic function and energy homeostasis. As such the present study suggests that increased heart rate and autonomic changes are prevalent in behavioural variant frontotemporal dementia, and are associated with changes in energy expenditure. An understanding of these changes and neural correlates may have potential relevance to disease progression and prognosis.
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Alterations in heart rate and the autonomic nervous system are related to atrophy of the mesial temporal cortex, insula, and amygdala, as well as energy homoeostasis, which is prevalent in FTLD.
“In addition, alterations in heart rate and the ANS are related to atrophy of the mesial temporal cortex, insula, and amygdala, as well as energy homoeostasis, which is prevalent in FTLD.218”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [218]
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- Authors
- Ahmed, R. M., Landin-Romero, R., Collet, T.-H., van der Klaauw, A. A., Devenney, E., Henning, E., Kiernan, M. C., Piguet, O., Farooqi, I. S., & Hodges, J. R.
- Affiliations
- The University of Sydney (AU)
- University of Cambridge (GB)
- UNSW Sydney (AU)
- Corresponding author
- Ahmed, Rebekah M.
- Hodges, John R.
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-27
- Volume
- 140
- Issue
- 1
- Pages
- 171-183
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC5379863
- OpenAlex
- W2541570986
- Cited by
- 58
- References
- 75
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 2 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 1
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Apollo (University of Cambridge) (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Apollo
- Funders
- National Science Foundation (1003139, 1022684)
- Wellcome Trust (099038/Z/12/Z)
- National Institute for Health and Care Research (NF-SI-0616-10065)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (145870, 155318)
- Centre of Excellence in Cognition and its Disorders, Australian Research Council (CE110001021, 1037746)
- Israel Science Foundation
- Medical Research Council
- Australian Research Council (CE 110001021, 1037746)
- National Health and Medical Research Council (1003139, 1037746)
- NIHR Cambridge Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia, energy expenditure, resting heart rate, autonomic dysfunction, eating behaviour, Alzheimer's disease, heart rate variability, cortical thickness, insula, amygdala, energy homeostasis, activity level
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Autonomic Nervous System Diseases, Cerebral Cortex, Energy Metabolism, Feeding Behavior, Female, Heart Rate, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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