Farooqi, I. Sadaf

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,936

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,912

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,998

Definition and diagnostic criteria of clinical obesity

Rubino, F., Cummings, D. E., Eckel, R. H., Cohen, R. V., Wilding, J. P. H., Brown, W. A., Stanford, F. C., Batterham, R. L., Farooqi, I. S., Farpour-Lambert, N. J., et al. (2025) · The Lancet Diabetes & Endocrinology

Obesity and Health PracticesObesity, Physical Activity, Diet

Cited by 1,811

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 1,778

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Yeo, G. S. H., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., & O'Rahilly, S. (1998) · Nature Genetics

Regulation of Appetite and ObesityGenetic Associations and Epidemiology

Cited by 1,159

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,105

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.

Farooqi, I. S., Wangensteen, T., Collins, S., Kimber, W., Matarese, G., Keogh, J. M., Lank, E., Bottomley, B., Lopez-Fernandez, J., Ferraz-Amaro, I., et al. (2007) · New England Journal of Medicine

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 732

Leptin Regulates Striatal Regions and Human Eating Behavior

Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science

Regulation of Appetite and ObesityEating Disorders and Behaviors

Cited by 622

Large, rare chromosomal deletions associated with severe early-onset obesity

Bochukova, E. G., Huang, N., Keogh, J., Henning, E., Purmann, C., Blaszczyk, K., Saeed, S., Hamilton-Shield, J., Clayton-Smith, J., O’Rahilly, S., et al. (2010) · Nature

Genomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology

Cited by 613

Genetics of Obesity in Humans

Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 583

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

Azizan, E. A. B., Poulsen, H., Tuluc, P., Zhou, J., Clausen, M. V., Lieb, A., Maniero, C., Garg, S., Bochukova, E. G., Zhao, W., et al. (2013) · Nature Genetics

Hormonal Regulation and HypertensionAdrenal and Paraganglionic Tumors

Cited by 544

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., et al. (2010) · Nature

Genomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology

Cited by 543

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 509

Modulation of Blood Pressure by Central Melanocortinergic Pathways

Greenfield, J. R., Miller, J. W., Keogh, J. M., Henning, E., Satterwhite, J. H., Cameron, G. S., Astruc, B., Mayer, J. P., Brage, S., See, T. C., et al. (2009) · New England Journal of Medicine

Regulation of Appetite and ObesityBlood Pressure and Hypertension Studies

Cited by 477

Obesity and the brain: how convincing is the addiction model?

Ziauddeen, H., Farooqi, I. S., & Fletcher, P. C. (2012) · Nature Reviews Neuroscience

Eating Disorders and BehaviorsRegulation of Appetite and Obesity

Cited by 462

Partial leptin deficiency and human adiposity

Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S. (2001) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 407

The central melanocortin system directly controls peripheral lipid metabolism

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 396

The energy balance model of obesity: beyond calories in, calories out

Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J., Mangelsdorf, D. J., O’Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., et al. (2022) · The American Journal of Clinical Nutrition

Regulation of Appetite and ObesityObesity, Physical Activity, Diet

Cited by 315

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Collet, T.-H., Dubern, B., Mokrosinski, J., Connors, H., Keogh, J. M., Mendes de Oliveira, E., Henning, E., Poitou-Bernert, C., Oppert, J.-M., Tounian, P., et al. (2017) · Molecular Metabolism

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 302

Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism

Semple, R. K., Achermann, J. C., Ellery, J., Farooqi, I. S., Karet, F. E., Stanhope, R. G., O’Rahilly, S., & Aparicio, S. A. (2005) · The Journal of Clinical Endocrinology & Metabolism

Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth Factors

Cited by 291

Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity

Asai, M., Ramachandrappa, S., Joachim, M., Shen, Y., Zhang, R., Nuthalapati, N., Ramanathan, V., Strochlic, D. E., Ferket, P., Linhart, K., et al. (2013) · Science

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 290

Human gain-of-function MC4R variants show signaling bias and protect against obesity

Lotta, L. A., Mokrosiński, J., Mendes de Oliveira, E., Li, C., Sharp, S. J., Luan, J., Brouwers, B., Ayinampudi, V., Bowker, N., Kerrison, N., et al. (2019) · Cell

Regulation of Appetite and ObesityReceptor Mechanisms and Signaling

Cited by 284

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Hedbacker, K., Birsoy, K., Wysocki, R. W., Asilmaz, E., Ahima, R. S., Farooqi, I. S., & Friedman, J. M. (2010) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 280