Siegwart, Daniel J.

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

Cheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 2,383

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

Dilliard, S. A., Cheng, Q., & Siegwart, D. J. (2021) · Proceedings of the National Academy of Sciences

Nanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Cited by 1,018

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

Liu, S., Cheng, Q., Wei, T., Yu, X., Johnson, L. T., Farbiak, L., & Siegwart, D. J. (2021) · Nature Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 653

Atrp in the design of functional materials for biomedical applications

Siegwart, D. J., Oh, J. K., & Matyjaszewski, K. (2012) · Progress in Polymer Science

Advanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applications

Cited by 613

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA

Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., & Siegwart, D. J. (2017) · Angewandte Chemie International Edition

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 540

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Dong, Y., Love, K. T., Dorkin, J. R., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R. L., Yin, H., Chen, Y., Vegas, A. J., et al. (2014) · Proceedings of the National Academy of Sciences

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 488

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

Zhang, D., Wang, G., Yu, X., Wei, T., Farbiak, L., Johnson, L. T., Taylor, A. M., Xu, J., Hong, Y., Zhu, H., et al. (2022) · Nature Nanotechnology

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 243

Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

Cheng, Q., Wei, T., Jia, Y., Farbiak, L., Zhou, K., Zhang, S., Wei, Y., Zhu, H., & Siegwart, D. J. (2018) · Advanced Materials

RNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers

Cited by 221

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H.-C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., et al. (2018) · Developmental Cell

Liver physiology and pathologyCancer-related Molecular Pathways

Cited by 180

Systemic mRNA delivery to the lungs by functional polyester-based carriers

Yan, Y., Xiong, H., Zhang, X., Cheng, Q., & Siegwart, D. J. (2017) · Biomacromolecules

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 111

Development of Cationic Polymer Coatings to Regulate Foreign‐Body Responses

Ma, M., Liu, W. F., Hill, P. S., Bratlie, K. M., Siegwart, D. J., Chin, J., Park, M., Guerreiro, J., & Anderson, D. G. (2011) · Advanced Materials

Polymer Surface Interaction Studiesbiodegradable polymer synthesis and properties

Cited by 59

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

Jia, Y., Li, L., Lin, Y.-H., Gopal, P., Shen, S., Zhou, K., Yu, X., Sharma, T., Zhang, Y., Siegwart, D. J., et al. (2022) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 59

The origin of hepatocellular carcinoma depends on metabolic zonation

Guo, J., Liang, R., Chung, A., Li, Z., Li, B., Chen, E., Li, L., Wang, J., Hsieh, M.-H., Fang, I. X., et al. (2026) · Science

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 24

Translational research to enable personalized treatment of cystic fibrosis

Hagemeijer, M. C., Siegwart, D. J., Strug, L. J., Cebotaru, L., Torres, M. J., Sofoluwe, A., & Beekman, J. M. (2018) · Journal of Cystic Fibrosis

Cystic Fibrosis Research AdvancesRNA Interference and Gene Delivery

Cited by 22