Chen, Irene A.

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 1,412

The Emergence of Competition Between Model Protocells

Chen, I. A., Roberts, R. W., & Szostak, J. W. (2004) · Science

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 435

Spontaneous network formation among cooperative RNA replicators

Vaidya, N., Manapat, M. L., Chen, I. A., Xulvi-Brunet, R., Hayden, E. J., & Lehman, N. (2012) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 383

RNA Catalysis in Model Protocell Vesicles

Chen, I. A., Salehi-Ashtiani, K., & Szostak, J. W. (2005) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 257

From self-assembled vesicles to protocells

Chen, I. A., & Walde, P. (2010) · Cold Spring Harbor Perspectives in Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 256

A kinetic study of the growth of fatty acid vesicles

Chen, I. A., & Szostak, J. W. (2004) · Biophysical Journal

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 251

The RNA world as a model system to study the origin of life

Pressman, A., Blanco, C., & Chen, I. A. (2015) · Current Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 225

Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles

Chen, I. A., & Szostak, J. W. (2004) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 164

Comprehensive experimental fitness landscape and evolutionary network for small RNA

Jiménez, J. I., Xulvi-Brunet, R., Campbell, G. W., Turk-MacLeod, R., & Chen, I. A. (2013) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 140

Confronting risks of mirror life

Adamala, K. P., Agashe, D., Belkaid, Y., Bittencourt, D. M. D. C., Cai, Y., Chang, M. W., Chen, I. A., Church, G. M., Cooper, V. S., Davis, M. M., et al. (2024) · Science

Space Science and Extraterrestrial LifeOrigins and Evolution of Life

Cited by 125

Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication

Rajamani, S., Ichida, J. K., Antal, T., Treco, D. A., Leu, K., Nowak, M. A., Szostak, J. W., & Chen, I. A. (2010) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 118

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA

Leu, K., Obermayer, B., Rajamani, S., Gerland, U., & Chen, I. A. (2011) · Nucleic Acids Research

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 85

Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences

Leu, K., Kervio, E., Obermayer, B., Turk-MacLeod, R. M., Yuan, C., Luevano, J.-M., Chen, E., Gerland, U., Richert, C., & Chen, I. A. (2013) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 78

Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences

Derr, J., Manapat, M. L., Rajamani, S., Leu, K., Xulvi-Brunet, R., Joseph, I., Nowak, M. A., & Chen, I. A. (2012) · Nucleic Acids Research

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 74

Molecular Crowding and Early Evolution

Saha, R., Pohorille, A., & Chen, I. A. (2014) · Origins of Life and Evolution of Biospheres

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 52

From Prelife to Life: How Chemical Kinetics Become Evolutionary Dynamics

Chen, I. A., & Nowak, M. A. (2012) · Accounts of Chemical Research

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 50

The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability

Ivica, N. A., Obermayer, B., Campbell, G. W., Rajamani, S., Gerland, U., & Chen, I. A. (2013) · Journal of Molecular Evolution

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 42

Selection for replicases in protocells

Bianconi, G., Zhao, K., Chen, I. A., & Nowak, M. A. (2013) · PLoS Computational Biology

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 31

Experimental fitness landscapes to understand the molecular evolution of RNA-based life

Athavale, S. S., Spicer, B., & Chen, I. A. (2014) · Current Opinion in Chemical Biology

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 25

Cell division: breaking up is easy to do.

Chen, I. A. (2009) · Current Biology

Origins and Evolution of LifeBacterial Genetics and Biotechnology

Cited by 24

The basic reproductive ratio of life

Manapat, M. L., Chen, I. A., & Nowak, M. A. (2010) · Journal of Theoretical Biology

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 19