The basic reproductive ratio of life
Open accessAbstract
Template-directed polymerization of nucleotides is believed to be a pathway for the replication of genetic material in the earliest cells. We assume that activated monomers are produced by prebiotic chemistry. These monomers can undergo spontaneous polymerization, a system that we call "prelife." Adding template-directed polymerization changes the equilibrium structure of prelife if the rate constants meet certain criteria. In particular, if the basic reproductive ratio of sequences of a certain length exceeds one, then those sequences can attain high abundance. Furthermore, if many sequences replicate, then the longest sequences can reach high abundance even if the basic reproductive ratios of all sequences are less than one. We call this phenomenon "subcritical life." Subcritical life suggests that sequences long enough to be ribozymes can become abundant even if replication is relatively inefficient. Our work on the evolution of replication has interesting parallels to infection dynamics. Life (replication) can be seen as an infection of prelife.
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Models of prebiotic polymerization of monomers that neglect the concatenation of oligomers also yield exponential length distributions at equilibrium.
“models of prebiotic polymerization of monomers that neglect the concatenation of oligomers (i.e. strong dependence of rate on substrate length) also yield exponential length distributions at equilibrium (61–63,72)”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [61]
The deterministic simulations are generalizations of a previously described 'prelife' framework.
“The deterministic simulations are generalizations of a previously described ‘prelife’ framework (Supplementary Data) (60–62).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [61]
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- Authors
- Manapat, M. L., Chen, I. A., & Nowak, M. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Nowak, Martin A.
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 263
- Issue
- 3
- Pages
- 317-327
- ISSN
- 0022-5193 (ISSN-L)
- PMC
- PMC2827768
- OpenAlex
- W2114893362
- Cited by
- 19
- References
- 86
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2012: 7
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Bill and Melinda Gates Foundation (37874)
- John Templeton Foundation
- Harvard University
- National Institutes of Health
- FAS Center for Systems Biology, Harvard University
- National Institute of General Medical Sciences (P50GM068763, R01GM078986)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- template polymerization, prebiotic chemistry, spontaneous polymerization, sequence abundance, ribozymes, origin of life, infection dynamics
- MeSH terms
- Biopolymers, Biological Evolution, Models, Theoretical, Templates, Genetic, Life
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