RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Steitz, Thomas A; Moore, Peter B

doi:10.1016/s0968-0004(03)00169-5

Cited by 319RNA and protein synthesis mechanismsRNA modifications and cancerEnzyme Structure and Function

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Steitz, Thomas A, Moore, Peter B·2003·Trends in Biochemical Sciences

DOI 10.1016/s0968-0004(03)00169-5

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Abstract

Recently, the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with substrates have been determined. These have provided exciting new insights into the principles of RNA structure, the mechanism of the peptidyl-transferase reaction and early events in the evolution of this RNA-protein complex assembly that is essential in all cells. The structures of the large subunit bound to a variety of antibiotics explain the effects of antibiotic resistance mutations and provide promise for the development of new antibiotics.

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RNA was the dominant genetic and functional biopolymer at an early stage in the evolution of life.
“The central role of RNA in modern cellular biochemistry, and especially the role of the large ribosomal RNA as the catalyst of protein synthesis (Steitz and Moore 2003), provides a powerful argument in support of RNA as the dominant genetic and functional biopolymer at an early stage in the evolution of life.”
From Protocells and RNA Self-Replication (2018) · cites this paper as Steitz and Moore 2003

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Authors: Steitz, T. A., & Moore, P. B.
Affiliations: Howard Hughes Medical Institute (US)
Yale University (US)
Corresponding author: Steitz, Thomas A
ORCID: Steitz, Thomas A
Moore, Peter B
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2003-08
Volume: 28
Issue: 8
Pages: 411-418
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/s0968-0004(03)00169-5
OpenAlex: W2162522101
Cited by: 319
References: 36
Citations by year: 2026: 5 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 20 · 2013: 10 · 2012: 15
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Agouron Institute
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
Keywords: ribosome, ribozymes, peptidyl transferase, RNA catalysis, large ribosomal subunit, Haloarcula marismortui, antibiotic resistance, antibiotic binding sites, RNA structure
MeSH terms: Drug Resistance, Microbial, Microscopy, Electron, Models, Chemical, Models, Molecular, Nucleic Acid Conformation, Peptide Elongation Factor Tu, Peptidyl Transferases, Protein Binding, Ribosomes, RNA, RNA, Messenger, RNA, Ribosomal, 23S, RNA, Transfer, RNA, Catalytic, Haloarcula marismortui

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RNA, the first macromolecular catalyst: the ribosome is a ribozyme

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