A Unified Polymerase Mechanism for Nonhomologous DNA and RNA Polymerases
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Ternary complexes of several different polymerases have an arrangement of reactive groups consistent with a two-metal ion mechanism for nucleotidyl transfer that may be common to all polymerases.
“Ternary complexes of several different polymerases have an arrangement of reactive groups consistent with a two-metal ion mechanism for nucleotidyl transfer that may be common to all polymerases (23).”
From DNA Replication Fidelity (2004) · cites this paper as [23]
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- Authors
- Steitz, T. A., Smerdon, S. J., Jäger, J., & Joyce, C. M.
- Affiliations
- Yale University (US)
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA
- Venue
- Science
- Published
- 1994-12-23
- Volume
- 266
- Issue
- 5193
- Pages
- 2022-2025
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061294794
- Cited by
- 280
- References
- 27
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-28550, P01GM039546, GM 39546, R01GM028550)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- DNA polymerase, RNA polymerase, polymerase mechanism, DNA replication, transcription
- MeSH terms
- Amino Acid Sequence, Binding Sites, Crystallization, DNA Polymerase I, Models, Molecular, Molecular Sequence Data, Protein Conformation, RNA-Directed DNA Polymerase, DNA-Directed RNA Polymerases, Viral Proteins, Protein Folding, Crystallography, X-Ray, HIV Reverse Transcriptase
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