DNA Polymerases: Structural Diversity and Common Mechanisms

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Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

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A general two-metal-ion mechanism for catalytic RNA

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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Structural basis for the 3′‐5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP

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An attempt to unify the structure of polymerases

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FUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES

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Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

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Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism,

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

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Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

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Crystal Structure of Rat DNA Polymerase β: Evidence for a Common Polymerase Mechanism

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Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69

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Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

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Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution

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Crystal structure of Thermus aquaticus DNA polymerase

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Structural basis for initiation of transcription from an RNA polymerase–promoter complex

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Structure of Taq polymerase with DNA at the polymerase active site

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Cocrystal structure of an editing complex of Klenow fragment with DNA.

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A Unified Polymerase Mechanism for Nonhomologous DNA and RNA Polymerases

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The 3′‐5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

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DNA- and RNA-dependent DNA polymerases

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Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

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Structural principles for the inhibition of the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

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Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme

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Elementary steps in the DNA polymerase I reaction pathway

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On the Direction of Translation of the T4 Deoxyribonucleic Acid Polymerase Gene in Vivo

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UV-induced DNA damage and repair: a review

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DNA Replication Fidelity

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Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

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DNA Replication Fidelity

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Eukaryotic DNA Polymerases

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Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

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Role of Magnesium in Genomic Stability

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Crystal Structure of a Y-Family DNA Polymerase in Action

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STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY

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CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

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The Structure and Function of Telomerase Reverse Transcriptase

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ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

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DNA Polymerase γ, The Mitochondrial Replicase

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Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

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Directed evolution of polymerase function by compartmentalized self-replication

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Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

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Structure of a Transcribing T7 RNA Polymerase Initiation Complex

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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

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Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

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The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase

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Evolution of foot-and-mouth disease virus

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DNA Polymerase Fidelity: Kinetics, Structure, and Checkpoints

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The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

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Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

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Structures of Mismatch Replication Errors Observed in a DNA Polymerase

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Structure and Mechanism of DNA Polymerase β

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RNA Polymerase: Structural Similarities Between Bacterial RNA Polymerase and Eukaryotic RNA Polymerase II

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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

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Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

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Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template

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Terminal Deoxynucleotidyl Transferase: The Story of a Misguided DNA Polymerase

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Evolution of DNA Polymerase Families: Evidences for Multiple Gene Exchange Between Cellular and Viral Proteins

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Simplified Normal Mode Analysis of Conformational Transitions in DNA-dependent Polymerases: the Elastic Network Model

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The Palm Subdomain-based Active Site is Internally Permuted in Viral RNA-dependent RNA Polymerases of an Ancient Lineage

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Nucleoside 5′-triphosphates: self-association, acid–base, and metal ion-binding properties in solution

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Structure of BeF3−-Modified Response Regulator PleD: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition

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Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass

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Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA

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Structure of the Tetrahymena Ribozyme

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Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase

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Eukaryotic DNA polymerases, a growing family

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Telomerase Mechanism of Telomere Synthesis

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Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase

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Unlocking the Sugar “Steric Gate” of DNA Polymerases

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Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase η

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Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins

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Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

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Arginine Methylation Regulates DNA Polymerase β

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Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

Zhou, B.-L., Pata, J. D., & Steitz, T. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00310-0 · Cited by 198 · see citing works

Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

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Comparative architecture of transposase and integrase complexes.

Rice, P. A., & Baker, T. A. (2001) · Nature Structural Biology · doi:10.1038/86166 · Cited by 192 · see citing works

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

Das, K., Martinez, S. E., Bauman, J. D., & Arnold, E. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2223 · Cited by 191 · see citing works

The origin of DNA genomes and DNA replication proteins

Forterre, P. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00360-0 · Cited by 190 · see citing works

Prokaryotic DNA polymerase I: evolution, structure, and “base flipping” mechanism for nucleotide selection

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Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase

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The human DINB1 gene encodes the DNA polymerase Polθ

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DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells

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Crystal Structure of the 2′-Specific and Double-Stranded RNA-Activated Interferon-Induced Antiviral Protein 2′-5′-Oligoadenylate Synthetase

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Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

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Capture of a third Mg 2+ is essential for catalyzing DNA synthesis

Gao, Y., & Yang, W. (2016) · Science · doi:10.1126/science.aad9633 · Cited by 178 · see citing works

A general strategy for expanding polymerase function by droplet microfluidics

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Fidelity of DNA replication—a matter of proofreading

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Drug Targets and Molecular Mechanisms of Drug Resistance in Chronic Hepatitis B

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Motors, Switches, and Contacts in the Replisome

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Structural Insights into the Origins of DNA Polymerase Fidelity

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Structural and Functional Comparisons of Nucleotide Pyrophosphatase/Phosphodiesterase and Alkaline Phosphatase: Implications for Mechanism and Evolution,

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DNA Replicases from a Bacterial Perspective

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