Trautwein, Christian

The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury

Klein, C., Wüstefeld, T., Assmus, U., Roskams, T., Rose-John, S., Müller, M., Manns, M. P., Ernst, M., & Trautwein, C. (2005) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 200

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

Hammerich, L., Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., et al. (2014) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 190

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Schneider, A. T., Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S. H., Roy, S., Benz, F., Schemmer, P., Büchler, M. W., Nachbur, U., et al. (2017) · Cancer Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 155

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Inzaugarat, M. E., Johnson, C. D., Holtmann, T. M., McGeough, M. D., Trautwein, C., Papouchado, B. G., Schwabe, R., Hoffman, H. M., Wree, A., & Feldstein, A. E. (2019) · Hepatology

Liver physiology and pathologyInflammasome and immune disorders

Cited by 148

Concanavalin A—induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice☆☆☆

Trautwein, C., Rakemann, T., Brenner, D. A., Streetz, K., Licato, L., Manns, M. P., & Tiegs, G. (1998) · Gastroenterology

Cell death mechanisms and regulationLiver physiology and pathology

Cited by 147

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

Bartneck, M., Scheyda, K. M., Warzecha, K. T., Rizzo, L. Y., Hittatiya, K., Luedde, T., Storm, G., Trautwein, C., Lammers, T., & Tacke, F. (2015) · Biomaterials

Nanoparticle-Based Drug DeliveryLiver physiology and pathology

Cited by 141

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

Mohs, A., Otto, T., Schneider, K. M., Peltzer, M., Boekschoten, M., Holland, C. H., Hudert, C. A., Kalveram, L., Wiegand, S., Saez-Rodriguez, J., et al. (2021) · Journal of Hepatology

Genomics, phytochemicals, and oxidative stressLiver Disease Diagnosis and Treatment

Cited by 137

Acute-phase response factor, increased binding, and target gene transcription during liver regeneration

Trautwein, C., Rakemann, T., Niehof, M., Rose-John, S., & Manns, M. (1996) · Gastroenterology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 131

Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study

Muti, H. S., Heij, L. R., Keller, G., Kohlruss, M., Langer, R., Dislich, B., Cheong, J.-H., Kim, Y.-W., Kim, H., Kook, M.-C., et al. (2021) · The Lancet Digital Health

AI in cancer detectionGastric Cancer Management and Outcomes

Cited by 126

Hyperstimulation With Interleukin 6 Inhibits Cell Cycle Progression After Hepatectomy in Mice

Wüstefeld, T., Rakemann, T., Kubicka, S., Manns, M. P., & Trautwein, C. (2000) · Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 120

Artificial intelligence for detection of microsatellite instability in colorectal cancer—a multicentric analysis of a pre-screening tool for clinical application

Echle, A., Ghaffari Laleh, N., Quirke, P., Grabsch, H. I., Muti, H. S., Saldanha, O. L., Brockmoeller, S. F., van den Brandt, P. A., Hutchins, G. G. A., Richman, S. D., et al. (2022) · ESMO Open

AI in cancer detectionGenetic factors in colorectal cancer

Cited by 111

TNF-α-Induced Expression of Adhesion Molecules in the Liver Is Under the Control of TNFR1—Relevance for Concanavalin A-Induced Hepatitis

Wolf, D., Hallmann, R., Sass, G., Sixt, M., Küsters, S., Fregien, B., Trautwein, C., & Tiegs, G. (2001) · The Journal of Immunology

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 109

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury

Schneider, K. M., Elfers, C., Ghallab, A., Schneider, C. V., Galvez, E. J. C., Mohs, A., Gui, W., Candels, L. S., Wirtz, T. H., Zuehlke, S., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology

Drug-Induced Hepatotoxicity and ProtectionGut microbiota and health

Cited by 108

Functional role of chemokines in liver disease models

Sahin, H., Trautwein, C., & Wasmuth, H. E. (2010) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 107

Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

Bartneck, M., Fech, V., Ehling, J., Govaere, O., Warzecha, K. T., Hittatiya, K., Vucur, M., Gautheron, J., Luedde, T., Trautwein, C., et al. (2016) · Hepatology

Liver physiology and pathologyImmune cells in cancer

Cited by 101

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K. M., Guenther, G., Ahmed, Y. A., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 101

Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.

StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 94

Concanavalin A-induced liver injury triggers hepatocyte proliferation.

Trautwein, C., Rakemann, T., Malek, N. P., Plümpe, J., Tiegs, G., & Manns, M. P. (1998) · Journal of Clinical Investigation

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 87

Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice

Kroy, D. C., Beraza, N., Tschaharganeh, D. F., Sander, L. E., Erschfeld, S., Giebeler, A., Liedtke, C., Wasmuth, H. E., Trautwein, C., & Streetz, K. L. (2010) · Hepatology

Cytokine Signaling Pathways and InteractionsLiver Disease Diagnosis and Treatment

Cited by 76

Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

Luchtefeld, M., Schunkert, H., Stoll, M., Selle, T., Lorier, R., Grote, K., Sagebiel, C., Jagavelu, K., Tietge, U. J. F., Assmus, U., et al. (2007) · The Journal of Experimental Medicine

Atherosclerosis and Cardiovascular DiseasesCytokine Signaling Pathways and Interactions

Cited by 69

GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease

Lebherz, C., Schlieper, G., Möllmann, J., Kahles, F., Schwarz, M., Brünsing, J., Dimkovic, N., Koch, A., Trautwein, C., Flöge, J., et al. (2017) · The American Journal of Medicine

Sepsis Diagnosis and TreatmentDiabetes Treatment and Management

Cited by 65

Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development

Ramadori, P., Drescher, H., Erschfeld, S., Schumacher, F., Berger, C., Fragoulis, A., Schenkel, J., Kensler, T. W., Wruck, C. J., Trautwein, C., et al. (2016) · Free Radical Biology and Medicine

Liver Disease Diagnosis and TreatmentGenomics, phytochemicals, and oxidative stress

Cited by 61

Skeletal Muscle Composition Predicts Outcome in Critically Ill Patients

Loosen, S. H., Schulze-Hagen, M., Püngel, T., Bündgens, L., Wirtz, T., Kather, J. N., Vucur, M., Paffenholz, P., Demir, M., Bruners, P., et al. (2020) · Critical Care Explorations

Nutrition and Health in AgingClinical Nutrition and Gastroenterology

Cited by 58

miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib

Roy, S., Bantel, H., Wandrer, F., Schneider, A. T., Gautheron, J., Vucur, M., Tacke, F., Trautwein, C., Luedde, T., & Roderburg, C. (2017) · Journal of Hepatology

MicroRNA in disease regulationLiver physiology and pathology

Cited by 56