NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Mechanism and Regulation of NLRP3 Inflammasome Activation

He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works

Fibrosis–a common pathway to organ injury and failure

Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428 · see citing works

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Wree, A., Eguchi, A., McGeough, M. D., Pena, C. A., Johnson, C. D., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2014) · Hepatology · doi:10.1002/hep.26592 · Cited by 945 · see citing works

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741 · see citing works

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S.-Y., Kurt-Jones, E. A., & Szabo, G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60777 · Cited by 735 · see citing works

Evolving therapies for liver fibrosis

Schuppan, D., & Kim, Y. O. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66028 · Cited by 596 · see citing works

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D., Shi, H., Gorka, O., Koenig, P.-A., Fromm, S., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.010 · Cited by 530 · see citing works

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.036 · Cited by 515 · see citing works

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

Wree, A., McGeough, M. D., Peña, C. A., Schlattjan, M., Li, H., Inzaugarat, M. E., Messer, K., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1170-1 · Cited by 486 · see citing works

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

Wen, H., Ting, J. P. ‐., & O'Neill, L. A. J. (2012) · Nature Immunology · doi:10.1038/ni.2228 · Cited by 455 · see citing works

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity

Brydges, S. D., Mueller, J. L., McGeough, M. D., Pena, C. A., Misaghi, A., Gandhi, C., Putnam, C. D., Boyle, D. L., Firestein, G. S., Horner, A. A., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.005 · Cited by 339 · see citing works

ATP release and purinergic signaling in NLRP3 inflammasome activation

Gombault, A., Baron, L., & Couillin, I. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00414 · Cited by 308 · see citing works

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

Kamari, Y., Shaish, A., Vax, E., Shemesh, S. S., Kandel-Kfir, M., Arbel, Y., Olteanu, S., Barshack, I., Dotan, S., Voronov, E., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.01.048 · Cited by 288 · see citing works

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284 · see citing works

Interleukin-1 participates in the progression from liver injury to fibrosis

Gieling, R. G., Wallace, K., & Han, Y.-P. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90564.2008 · Cited by 279 · see citing works

NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice

Wree, A., McGeough, M. D., Inzaugarat, M. E., Eguchi, A., Schuster, S., Johnson, C. D., Peña, C. A., Geisler, L. J., Papouchado, B. G., Hoffman, H. M., et al. (2018) · Hepatology · doi:10.1002/hep.29523 · Cited by 266 · see citing works

Inflammasome-mediated regulation of hepatic stellate cells

Watanabe, A., Sohail, M. A., Gomes, D. A., Hashmi, A., Nagata, J., Sutterwala, F. S., Mahmood, S., Jhandier, M. N., Shi, Y., Flavell, R. A., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90223.2008 · Cited by 233 · see citing works

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

Pellegrini, C., Antonioli, L., López‐Castejón, G., Blandizzi, C., & Fornai, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00036 · Cited by 212 · see citing works

Inflammasomes in liver fibrosis

Alegre, F., Pelegrin, P., & Feldstein, A. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1601350 · Cited by 176 · see citing works

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies

Li, J., Liao, Z., Ping, J., Xu, D., & Wang, H. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2180-y · Cited by 167 · see citing works

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

Dixon, L. J., Berk, M. P., Thapaliya, S., Papouchado, B. G., & Feldstein, A. E. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.45 · Cited by 159 · see citing works

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

Boaru, S. G., Borkham‐Kamphorst, E., Tihaa, L., Haas, U., & Weiskirchen, R. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-49 · Cited by 142 · see citing works

The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies

Xu, J., Liu, X., Koyama, Y., Wang, P., Lan, T., Kim, I., Kim, I. H., Ma, H., & Kisseleva, T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00167 · Cited by 126 · see citing works

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

Kluwe, J., Wongsiriroj, N., Troeger, J. S., Gwak, G., Dapito, D. H., Pradère, J., Jiang, H., Siddiqi, M., Piantedosi, R., O’Byrne, S. M., et al. (2011) · Gut · doi:10.1136/gut.2010.209551 · Cited by 121 · see citing works

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

Jiang, S., Zhang, Y., Zheng, J., Li, X., Yao, Y., Wu, Y., Song, S., Sun, P., Nan, J., & Lian, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.040 · Cited by 104 · see citing works

Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation

Cai, S., Yang, R., Li, Y., Ning, Z., Zhang, L., Zhou, G.-S., Luo, W., Li, D.-H., Chen, Y., Pan, M., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6498 · Cited by 103 · see citing works

A new method for removal of mononuclear phagocytes from heterogeneous cell populations in vitro, using the liposome-mediated macrophage ‘suicide’ technique

Claassen, I. J. T. M., van Rooijen, N., & Claassen, E. (1990) · Journal of Immunological Methods · doi:10.1016/0022-1759(90)90376-7 · Cited by 91 · see citing works

Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP 3 inflammasome pathway

Wu, X., Zhang, F., Xiong, X., Lu, C., Lian, N., Lu, Y., & Zheng, S. (2015) · IUBMB Life · doi:10.1002/iub.1348 · Cited by 88 · see citing works

Inflammasome biology in fibrogenesis

Ouyang, X., Ghani, A., & Mehal, W. Z. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.020 · Cited by 69 · see citing works

Molecular Activation of the NLRP3 Inflammasome in Fibrosis: Common Threads Linking Divergent Fibrogenic Diseases

Artlett, C. M., & Thacker, J. D. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6148 · Cited by 59 · see citing works

Palmitic acid elicits hepatic stellate cell activation through inflammasomes and hedgehog signaling

Duan, N.-N., Liu, X.-J., & Wu, J. H. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.03.012 · Cited by 51 · see citing works

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

Gaul, S., Leszczynska, A., Alegre, F., Kaufmann, B. K., Johnson, C. D., Adams, L. A., Wree, A., Damm, G., Seehofer, D., Calvente, C. J., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.041 · Cited by 556 · see citing works

The NLRP3 inflammasome: contributions to inflammation-related diseases

Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492 · see citing works

Role of the Inflammasome in Liver Disease

Ribeiro, M. D. C., & Szabó, G. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-032521-102529 · Cited by 280 · see citing works

Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome

Zhang, Y., Zhang, S., Li, B., Luo, Y., Gong, Y., Jin, X., Zhang, J., Zhou, Y., Zhuo, X., Wang, Z., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab114 · Cited by 272 · see citing works

Immunological mechanisms and therapeutic targets of fatty liver diseases

Wang, H., Mehal, W. Z., Nagy, L. E., & Rotman, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00579-3 · Cited by 222 · see citing works

Inflammasomes and Fibrosis

Zhang, W., Chen, S., Zhou, S., Wu, S., & Wang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643149 · Cited by 208 · see citing works

STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

Xiao, Y., Zhao, C., Tai, Y., Li, B., Lan, T., Lai, E., Dai, W., Guo, Y., Gan, C., Kostallari, E., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102691 · Cited by 182 · see citing works

Mitochondrial DNA in liver inflammation and oxidative stress

Zhang, X., Wu, X., Hu, Q., Wu, J., Wang, G., Hong, Z., & Ren, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.020 · Cited by 163 · see citing works

Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

Khanam, A., Saleeb, P. G., & Kottilil, S. (2021) · Cells · doi:10.3390/cells10051097 · Cited by 132 · see citing works

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112 · see citing works

Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis

Babuta, M., Morel, C., Ribeiro, M. D. C., Calenda, C. D., Ortega‐Ribera, M., Nagesh, P. T., Copeland, C., Zhuang, Y., Wang, Y., Cho, Y., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331447 · Cited by 110 · see citing works

FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models

O’Farrell, M., Duke, G. M., Crowley, R., BUCKLEY, D. I., Martins, E. B., Bhattacharya, D., Friedman, S. L., & Kemble, G. W. (2022) · Scientific Reports · doi:10.1038/s41598-022-19459-z · Cited by 104 · see citing works

Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study

Zhang, L., Zhan, D.-L., Chen, Y., Wang, W., He, C., Lin, Y., Lin, Z., & Lin, Z. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02572-w · Cited by 106 · see citing works

Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury

Frissen, M., Liao, L., Schneider, K. M., Djudjaj, S., Haybaeck, J., Wree, A., Rolle-Kampczyk, U. E., von Bergen�, M., Latz, E., Boor, P., et al. (2020) · Hepatology · doi:10.1002/hep.31494 · Cited by 92 · see citing works

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Knorr, J., Kaufmann, B. K., Inzaugarat, M. E., Holtmann, T. M., Geisler, L. J., Hundertmark, J., Kohlhepp, M. S., Boosheri, L. M., Chilin-Fuentes, D., Birmingham, A., et al. (2022) · Hepatology · doi:10.1002/hep.32776 · Cited by 93 · see citing works

Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

Sharma, S. K., Guillou, D. L., & Chen, J. Y. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00832-w · Cited by 95 · see citing works

NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?

Chen, X., Zhang, D., Li, Y., Wang, W., Bei, W., & Guo, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105885 · Cited by 84 · see citing works

Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies

Li, J., Guo, C., Liu, Y., Han, B., Lv, Z., Jiang, H., Li, S., & Zhang, Z. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.01.019 · Cited by 81 · see citing works

Hepatic Stellate Cell-Immune Interactions in NASH

Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79 · see citing works

Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis

Zhu, Z., Hu, R., Li, J., Xing, X., Chen, J., Zhou, Q. X., & Sun, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107660 · Cited by 80 · see citing works

Oxidative stress-related canonical pyroptosis pathway, as a target of liver toxicity triggered by zinc oxide nanoparticles

Pei, X., Jiang, H., Li, C., Li, D., & Tang, S. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130039 · Cited by 77 · see citing works

The multifaceted role of cathepsins in liver disease

Ruiz-Blázquez, P., Pistorio, V., Fernández-Fernández, M., & Moles, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.031 · Cited by 76 · see citing works

Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development

Ignat, S.-R., Dinescu, S., Hermenean, A. O., & Costache, M. (2020) · Cells · doi:10.3390/cells9020461 · Cited by 72 · see citing works

Pyroptosis: Mechanisms and Links with Fibrosis

Song, Z., Gong, Q., & Guo, J. (2021) · Cells · doi:10.3390/cells10123509 · Cited by 68 · see citing works

Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy

Wang, L., Wang, Y., & Quan, J. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00207-w · Cited by 63 · see citing works

The NLRP3 inflammasome in fibrosis and aging: The known unknowns

Liu, Y., Xu, X., Lei, W., Hou, Y., Zhang, Y., Tang, R., Yang, Z. P., Tian, Y., Zhu, Y., Wang, C., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101638 · Cited by 62 · see citing works

Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions

Myint, M., Oppedisano, F., De Giorgi, V., Kim, B.-M., Marincola, F. M., Alter, H. J., & Nesci, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04627-0 · Cited by 61 · see citing works

Role of inflammasomes and cytokines in immune dysfunction of liver cirrhosis

Das, P. P., & Medhi, S. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156347 · Cited by 63 · see citing works

Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

Dong, Z., Zhuang, Q., Ning, M., Wu, S., Lu, L., & Wan, X. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.21 · Cited by 61 · see citing works

Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner

Holtmann, T. M., Inzaugarat, M. E., Knorr, J., Geisler, L. J., Schulz, M., Bieghs, V., Frissen, M., Feldstein, A. E., Tacke, F., Trautwein, C., et al. (2021) · Cells · doi:10.3390/cells10102618 · Cited by 60 · see citing works

Treating inflammation to combat non-alcoholic fatty liver disease

Wiering, L., & Tacke, F. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0194 · Cited by 58 · see citing works

Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

Charan, H. V., Dwivedi, D. K., Khan, S., & Jena, G. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.006 · Cited by 55 · see citing works

Antifibrotic effect and long‐term outcome of SGLT2 inhibitors in patients with NAFLD complicated by diabetes mellitus

Arai, T., Atsukawa, M., Tsubota, A., Mikami, S., Uojima, H., Yoshikata, K., Ono, H., Kawano, T., Yoshida, Y., Tanabe, T., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.2069 · Cited by 54 · see citing works

Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

Kaufmann, B., Kui, L., Reca, A., Leszczynska, A., Kim, A. D., Booshehri, L. M., Wree, A., Friess, H., Hartmann, D., Broderick, L., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.06.007 · Cited by 51 · see citing works

Innate Immunity and MASLD

Meyer, M., Schwärzler, J., Jukic, A., & Tilg, H. (2024) · Biomolecules · doi:10.3390/biom14040476 · Cited by 50 · see citing works

Dimethyl fumarate protects thioacetamide‐induced liver damage in rats: Studies on Nrf2, NLRP3, and NF‐κB

Dwivedi, D. K., Jena, G., & Kumar, V. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22476 · Cited by 48 · see citing works

Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis

Wang, X., Wang, G., Qu, J., Yuan, Z., Pan, R., & Li, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00200 · Cited by 46 · see citing works

Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice

Lin, Y., Wang, S., Gao, L., Zhou, Z., Yang, Z., Lin, J., Ren, S., Xing, H., & Wu, B. (2020) · Theranostics · doi:10.7150/thno.50281 · Cited by 45 · see citing works

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

Kaufmann, B. K., Leszczynska, A., Reca, A., Booshehri, L. M., Onyuru, J., Tan, Z., Wree, A., Friess, H., Hartmann, D., Papouchado, B. G., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154446 · Cited by 43 · see citing works

Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome

Liu, D., Qin, H., Bi-xian, Y., Du, B., & Xue-lin, Y. (2020) · Drug Development Research · doi:10.1002/ddr.21649 · Cited by 42 · see citing works

Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH

Bala, S., Ganz, M., Babuta, M., Zhuang, Y., Csák, T., Calenda, C. D., & Szabó, G. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00626-1 · Cited by 41 · see citing works

Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway

Cui, L., Li, C., Zhuo, Y., Yang, L., Cui, N., Li, Y., & Zhang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110216 · Cited by 40 · see citing works

Galectin-3 in Inflammasome Activation and Primary Biliary Cholangitis Development

Arsenijević, A., Stojanović, B., Milovanović, J., Arsenijević, D., Arsenijević, N., & Milovanović, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145097 · Cited by 40 · see citing works

Galectin-3: therapeutic targeting in liver disease

MacKinnon, A. C., Tonev, D., Jacoby, B., Pinzani, M., & Slack, R. J. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2258280 · Cited by 39 · see citing works

The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity

Putnam, C. D., Broderick, L., & Hoffman, H. M. (2023) · Immunological Reviews · doi:10.1111/imr.13292 · Cited by 38 · see citing works

Mechanisms of nonalcoholic fatty liver disease and implications for surgery

Kaufmann, B. K., Reca, A., Wang, B., Friess, H., Feldstein, A. E., & Hartmann, D. (2020) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-020-01965-1 · Cited by 38 · see citing works

Liver Fibrosis—From Mechanisms of Injury to Modulation of Disease

Liedtke, C., Nevzorova, Y. A., Luedde, T., Zimmermann, H. W., Kroy, D. C., Strnad, P., Berres, M., Bernhagen, J., Tacke, F., Nattermann, J., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.814496 · Cited by 40 · see citing works

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Qiang, R., Li, Y., Dai, X.-C., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.978190 · Cited by 36 · see citing works

Curcumin Alleviates Aflatoxin B1-Induced Liver Pyroptosis and Fibrosis by Regulating the JAK2/NLRP3 Signaling Pathway in Ducks

Cui, Y., Wang, Q., Zhang, X., Yang, X., Shi, Y., Li, Y., & Song, M. (2023) · Foods · doi:10.3390/foods12051006 · Cited by 36 · see citing works

The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets

Weber, A. N. R., McManus, R. M., Hornung, V., Geyer, M., Kuemmerle-Deschner, J. B., & Latz, E. (2025) · Nature Immunology · doi:10.1038/s41590-025-02230-7 · Cited by 38 · see citing works

Kupffer Cells: Important Participant of Hepatic Alveolar Echinococcosis

Liu, Y., Tian, F., Shan, J., Gao, J. P., Li, B., Lv, J., Zhou, X., Cai, X., Wen, H., & Ma, X. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00008 · Cited by 35 · see citing works

The peripheral CB 1 receptor antagonist JD5037 attenuates liver fibrosis via a CB 1 receptor /β‐arrestin1/ Akt pathway

Tan, S., Liu, H., Ke, B., Jiang, J., & Wu, B. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15010 · Cited by 35 · see citing works

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Kim, H., Choi, Y. J., Kim, S. K., Kim, H., Jun, D. W., Yoon, K., Kim, N., Hwang, J., Kim, Y. M., Lim, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02345-1 · Cited by 35 · see citing works

Involvement of Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3 Inflammasome in the Pathogenesis of Liver Diseases

Shi, C., Yang, H., & Zhang, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00139 · Cited by 34 · see citing works

Therapeutic modulation of the liver immune microenvironment

Tilg, H., Adolph, T. E., & Tacke, F. (2023) · Hepatology · doi:10.1097/hep.0000000000000386 · Cited by 31 · see citing works

Purinergic signaling in hepatic disease

Velázquez‐Miranda, E., Díaz‐Muñoz, M., & Vázquez‐Cuevas, F. G. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09680-3 · Cited by 31 · see citing works

Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice

Huang, P. C., Ma, H., Cao, Y., Zhan, T., Zhang, T., Wang, X., Zhang, Y., Xu, J., & Xia, C.-M. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05584-1 · Cited by 30 · see citing works

The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging

Gallego, P., Castejón‐Vega, B., Campo, J. A. D., & Cordero, M. D. (2020) · Cells · doi:10.3390/cells9102148 · Cited by 29 · see citing works

Attenuation of hepatic fibrosis by p-Coumaric acid via modulation of NLRP3 inflammasome activation in C57BL/6 mice

Truong, T. M. T., Seo, S. H., Chung, S., & Kang, I. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109204 · Cited by 28 · see citing works

Oxymatrine alleviates high-fat diet/streptozotocin-induced non-alcoholic fatty liver disease in C57BL/6 J mice by modulating oxidative stress, inflammation and fibrosis

Lou, D., Fang, Q., He, Y., Ma, R., Wang, X., Li, H., & Qi, M.-Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116491 · Cited by 27 · see citing works

P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells

Jiang, M., Cui, B., Wu, Y., Zhang, Y., Shang, Y., Liu, J., Yang, H., Qiao, C., Zhan, Z., Ye, H., et al. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.07.023 · Cited by 27 · see citing works

The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

Li, N., Wang, L., Li, L., Yang, M.-Z., Wang, Q., Bai, X., Gao, F., Yuan, Y., Yu, Z., & Ren, Z. (2023) · Military Medical Research · doi:10.1186/s40779-023-00489-1 · Cited by 32 · see citing works

Saikosaponin d Alleviates Liver Fibrosis by Negatively Regulating the ROS/NLRP3 Inflammasome Through Activating the ERβ Pathway

Zhang, K., Lin, L., Zhu, Y., Zhang, N., Zhou, M., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.894981 · Cited by 26 · see citing works

Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury

Wang, Y., Xu, G., Wang, Z., Li, R., Zhan, X., Liu, H., Qin, Q., Li, W., Wang, X., Zhang, M., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107352 · Cited by 25 · see citing works

Metabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice

Isaacs‐Ten, A., Moreno‐Gonzalez, M., Bone, C., Märtens, A., Bernuzzi, F., Ludwig, T., Hellmich, C., Hiller, K., Rushworth, S. A., & Beraza, N. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.12.010 · Cited by 25 · see citing works

Regulation of the macrophage‐hepatic stellate cell interaction by targeting macrophage peroxisome proliferator‐activated receptor gamma to prevent non‐alcoholic steatohepatitis progression in mice

Ni, X., Ji, P., Chen, Y., Li, X., Li, S., Lian, M., Guo, C. J., & Hua, J. (2022) · Liver International · doi:10.1111/liv.15441 · Cited by 23 · see citing works

Transcriptional enhancement of GBP‐5 by BATF aggravates sepsis‐associated liver injury via NLRP3 inflammasome activation

Guo, H., Ni, M.-M., Xu, J., Chen, F., Yao, Z., Yao, Y., Liu, C., & Du, Q. (2021) · The FASEB Journal · doi:10.1096/fj.202100234r · Cited by 22 · see citing works

Intercellular communication among liver cells in the perisinusoidal space of the injured liver: Pathophysiology and therapeutic directions

Ezhilarasan, D., & Najimi, M. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30915 · Cited by 22 · see citing works

Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches

Mahmoudi, S. K., Tarzemani, S., Aghajanzadeh, T., Kasravi, M., Hatami, B., Zali, M. R., & Baghaei, K. (2024) · European journal of medical research · doi:10.1186/s40001-024-01708-8 · Cited by 22 · see citing works

Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis

Stoess, C., Leszczynska, A., Kui, L., & Feldstein, A. E. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1218807 · Cited by 22 · see citing works

Antarctic krill peptide alleviates liver fibrosis via downregulating the secondary bile acid mediated NLRP3 signaling pathway

Yue, H., Li, Y., Cai, W., Bai, X., Dong, P., & Wang, J. (2022) · Food & Function · doi:10.1039/d1fo04241f · Cited by 21 · see citing works

Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis?

Li, X., Zhang, Q., Wang, Z., Zhuang, Q., & Zhao, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.802251 · Cited by 21 · see citing works

Pachymic acid alleviates experimental pancreatic fibrosis through repressing NLRP3 inflammasome activation

Fu, L., Chen, M., Ji, J., Tang, R., Huang, J., Zhang, X., & Yu, J. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac114 · Cited by 19 · see citing works

Role of NLR family pyrin domain-containing 3 inflammasome in the activation of pancreatic stellate cells

Li, C., Cui, L., Zhang, L., Yang, L., Zhuo, Y., Cui, N., & Zhang, S. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112634 · Cited by 18 · see citing works

Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Yang, H., Wang, J., & Liu, Z. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17277 · Cited by 17 · see citing works

Inhibition of the NF-κB Signaling Pathway Alleviates Pyroptosis in Bladder Epithelial Cells and Neurogenic Bladder Fibrosis

Chen, J., Li, Q., Hong, Y., Zhou, X., Yu, C., Tian, X., Zhao, J., Long, C., Shen, L., Wu, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311160 · Cited by 17 · see citing works

Inflammasome as an Effective Platform for Fibrosis Therapy

Chen, T., Xiao, F., Li, N., Shan, S., Qi, M., Wang, Z., Zhang, S., Wei, W., & Sun, W. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s304180 · Cited by 17 · see citing works

Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway

Li, X., Li, H., Zhang, S., Zhang, R., Li, J., Wei, Y., Yang, C., Zhang, F., & Zhou, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17039 · Cited by 17 · see citing works

NLRP3 inflammasome: structure, mechanism, drug-induced organ toxicity, therapeutic strategies, and future perspectives

Singh, D. D. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00167f · Cited by 16 · see citing works

Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines

Köse-Vogel, N., Stengel, S., Gardey, E., Kirchberger-Tolstik, T., Reuken, P. A., Stallmach, A., & Bruns, T. (2019) · Cells · doi:10.3390/cells9010079 · Cited by 16 · see citing works

Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model

Zhang, G., Tang, L., Liu, H., Liu, D., Wang, M., Cai, J., Liu, W., Nie, W., Zhang, Y., & Yu, X. (2021) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x21500944 · Cited by 15 · see citing works

NOD-like receptors in the pathogenesis of metabolic (dysfunction)-associated fatty liver disease: Therapeutic agents targeting NOD-like receptors

Khanmohammadi, S., Ramos‐Molina, B., & Kuchay, M. S. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102788 · Cited by 15 · see citing works

Angiotensin II can trigger HSC-LX2 pyroptosis through both classical and non-classical pathways

Xie, Z.-Y., Xu, Y., & Li, Y. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120878 · Cited by 15 · see citing works

Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications

Tarantino, G., & Citro, V. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.119467 · Cited by 14 · see citing works

Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes

Liu, L.-Z., Wei, Y., Xie, N., Cai, H., & Lin, Y. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.2.25 · Cited by 14 · see citing works

Gut microbiome-specific nanoparticle-based therapeutics for liver diseases

Khurana, A., & Hartmann, P. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i27.109105 · Cited by 15 · see citing works

Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury

Zhang, Q., Liu, W., Bulek, K., Wang, H., McMullen, M. R., Wu, X., Welch, N., Zhang, R., Dasarathy, J., Dasarathy, S., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000114 · Cited by 13 · see citing works

The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights

Arrè, V., Negro, R., & Giannelli, G. (2024) · Annals of Hepatology · doi:10.1016/j.aohep.2024.101772 · Cited by 13 · see citing works

Inflammatory and Non-Inflammatory Mechanisms Controlling Cirrhosis Development

Sánchez, P. S., Rigual, M. D. M., & Djouder, N. (2021) · Cancers · doi:10.3390/cancers13205045 · Cited by 13 · see citing works

Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling

Xu, X., Feng, J., Wang, X., Zeng, X., Luo, Y., He, X., Yang, M., Lv, T., Feng, Z., Bao, L., et al. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00562 · Cited by 12 · see citing works

The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis

Kim, J.-W., Tung, H., Ke, M., Xu, P., Cai, X., Xi, Y., Xu, M., Ren, S., Huang, Y., Bhowmik, A., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000001133 · Cited by 12 · see citing works

Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

Kim, D.-H., Choi, G. H., Song, E.-B., Lee, H. N., Kim, J. K., Jang, Y., Park, J., Chi, S., Han, J., Kim, D., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102047 · Cited by 11 · see citing works

IL‑22 alleviates the fibrosis of hepatic stellate cells via the inactivation of NLRP3 inflammasome signaling

Xing, Z., Yayun, W., & Liu, N. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10522 · Cited by 11 · see citing works

IL-1 family of cytokines in gastrointestinal and liver disorders

Schwärzler, J., Menghini, P., Dinarello, C. A., Cominelli, F., & Tilg, H. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01141-0 · Cited by 10 · see citing works

Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis

Hu, T., Chen, M., Tian, S., Luo, P., & Zhang, J.-P. (2025) · Toxics · doi:10.3390/toxics13040287 · Cited by 10 · see citing works

Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice

Xia, L.-Y., Yu, N.-R., Huang, S., Qu, H. Y., Li, Q., Zhao, Q., & Leng, Y. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01569-9 · Cited by 10 · see citing works

AdipoRon attenuates steatosis, inflammation and fibrosis in murine diet‐induced NASH via inhibiting ER stress

Nie, L., He, K., Wu, W., Zhang, H., Gao, C., Xiong, B., Li, S., Xie, Y., Xie, H., & Yang, X. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16542 · Cited by 9 · see citing works

Gut microbiota's role in NAFLD- and HBV/HCV-related hepatocellular carcinoma: Mechanisms and therapeutic implications

Singh, G., Ansari, S., Yadav, S., & Aran, K. R. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108273 · Cited by 9 · see citing works

Exploring the Axis of Gut Microbiota‐Inflammatory Cytokine‐Atrial Fibrillation in the Pathogenesis of Atrial Fibrillation

Chen, J., Wang, Y., Wang, K., Mei, Z., & Wang, L. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70379 · Cited by 8 · see citing works

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Deng, J., Qin, L., Qin, S., Wu, R., Huang, G., Fang, Y., Huang, L., & Zhou, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s448723 · Cited by 8 · see citing works

NLRP3 inflammasome increases hepatic fibrosis by inducing inflammatory signals in hepatic stellate cells

Rychlicki, C., Agostinelli, L. J., Mingarelli, E., Saccomanno, S., Pinto, C., Pierantonelli, I., Trozzi, L., Benedetti, A., Marzioni, M., Minicis, S. D., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.01.047

Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

Charan, H. V., Dwivedi, D. K., Khan, S., & Jena, G. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.006 · Cited by 55 · see citing works

NLRP3 inflammasome activation in leucocytes drives hepatic stellate cell activation and fibrosis in non-alcoholic steatohepatitis

Kaufmann, B. K., Kui, L., Reca, A., Leszczyńska, A. N., Kim, A. D., Booshehri, L. M., Wree, A., Friess, H., Hüser, N., Hartmann, D., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0042-1754729

Direct activation of Nlrp3 inflammasome in hepatic stellate cells leads to upregulation of fibrotic markers

Inzaugarat, M. E., McGeough, M. D., Holtmann, T. M., Frissen, M., Johnson, C. D., Hoffman, H. H., Feldstein, A. E., Trautwein, C., & Wree, A. (2017) · Journal of Hepatology · doi:10.1016/s0168-8278(17)30338-0 · Cited by 2 · see citing works

Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

Kaufmann, B., Kui, L., Reca, A., Leszczynska, A., Kim, A. D., Booshehri, L. M., Wree, A., Friess, H., Hartmann, D., Broderick, L., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.06.007 · Cited by 51 · see citing works