Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130 · see citing works

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., & Davis, R. J. (2008) · Science · doi:10.1126/science.1160794 · Cited by 604 · see citing works

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R., Zein, N. N., & Feldstein, A. E. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01774.x · Cited by 597 · see citing works

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., et al. (2004) · Nature Medicine · doi:10.1038/nm980 · Cited by 384 · see citing works

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

Ueki, K., Kondo, T., Tseng, Y., & Kahn, C. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402511101 · Cited by 382 · see citing works

Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses

Shi, Z., Wakil, A. E., & Rockey, D. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10663 · Cited by 310 · see citing works

Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations

Preiss, D., & Sattar, N. A. (2008) · Clinical Science · doi:10.1042/cs20070402 · Cited by 292 · see citing works

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†

Singh, R., Wang, Y., Xiang, Y., Tanaka, K. E., Gaarde, W. A., & Czaja, M. J. (2008) · Hepatology · doi:10.1002/hep.22578 · Cited by 224 · see citing works

A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver

Akhurst, B., Croager, E. J., Farley-Roche, C. A., Ong, J., Dumble, M. L., Knight, B., & Yeoh, G. C. (2001) · Hepatology · doi:10.1053/jhep.2001.26751 · Cited by 212 · see citing works

Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice

McCuskey, R. S., Ito, Y., Robertson, G. R., McCuskey, M. K., Perry, M. A., & Farrell, G. C. (2004) · Hepatology · doi:10.1002/hep.20302 · Cited by 211 · see citing works

Beyond insulin resistance

Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 204 · see citing works

Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

Carter-Kent, C. A., Zein, N. N., & Feldstein, A. E. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01709.x · Cited by 202 · see citing works

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Stebbins, J. L., De, S. K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.-H., Cellitti, J. F., Riel-Mehan, M., Emdadi, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805677105 · Cited by 186 · see citing works

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

Franckhauser, S., Elias, I., Sopasakis, V. R., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008) · Diabetologia · doi:10.1007/s00125-008-0998-8 · Cited by 166 · see citing works

Liver diseases and metabolic syndrome

Watanabe, S., Yaginuma, R., Ikejima, K., & Miyazaki, A. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2193-6 · Cited by 157 · see citing works

Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.

StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00901-6 · Cited by 94 · see citing works

Diverse regulation of NF-κB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver

Romics, L., Kodys, K., Dolganiuc, A., Graham, L. S., Velayudham, A., Mandrekar, P., & Szabó, G. (2004) · Hepatology · doi:10.1002/hep.20304 · Cited by 87 · see citing works

Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice

Sakamori, R., Takehara, T., Ohnishi, C., Tatsumi, T., Ohkawa, K., Takeda, K., Akira, S., & Hayashi, N. (2007) · Hepatology · doi:10.1002/hep.21837 · Cited by 71 · see citing works

NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes

Bugianesi, E., Vanni, E., & Marchesini, G. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0029-z · Cited by 70 · see citing works

Gene Expression Patterns in Hepatic Tissue and Visceral Adipose Tissue of Patients with Non-Alcoholic Fatty Liver Disease

Baranova, A. V., Schlauch, K. A., Elariny, H. A., Jarrar, M. H., Bennett, C. G., Nugent, C., Gowder, S., Younoszai, Z., Collantes, R. S., Chandhoke, V., et al. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9187-y · Cited by 55 · see citing works

Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice

Wuestefeld, T., Klein, C., Streetz, K., Beraza, N., Schölmerich, J., Burgart, L., Zender, L., Kubicka, S., Gores, G., Manns, M., et al. (2005) · Hepatology · doi:10.1002/hep.20912 · Cited by 39 · see citing works

Neuropoietin Attenuates Adipogenesis and Induces Insulin Resistance in Adipocytes

White, U. A., Stewart, W. C., Mynatt, R. L., & Stephens, J. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710462200 · Cited by 32 · see citing works

IL-6 pathway in the liver: From physiopathology to therapy

Schmidt-Arras, D., & Rose-John, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.004 · Cited by 881 · see citing works

Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

Liedtke, C., Luedde, T., Sauerbruch, T., Scholten, D., Streetz, K. L., Tacke, F., Tolba, R. H., Trautwein, C., Trebicka, J., & Weiskirchen, R. (2013) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-6-19 · Cited by 336 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

Tang, L.-Y., Heller, M., Meng, Z., Yu, L., Tang, Y., Zhou, M., & Zhang, Y. E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.773085 · Cited by 278 · see citing works

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

Wang, H., Lafdil, F., Kong, X., & Gao, B. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.536 · Cited by 268 · see citing works

The JAK / STAT pathway in obesity and diabetes

Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · FEBS Journal · doi:10.1111/febs.13709 · Cited by 253 · see citing works

STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

Gao, B., Wang, H., Lafdil, F., & Feng, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.029 · Cited by 179 · see citing works

Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10–deficient mice

Miller, A. M., Wang, H., Bertola, A., Park, O., Horiguchi, N., Ki, S. H., Yin, S., Lafdil, F., & Gao, B. (2011) · Hepatology · doi:10.1002/hep.24517 · Cited by 162 · see citing works

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Dong, J., Viswanathan, S., Adami, E., Singh, B. K., Chothani, S. P., Ng, B., Lim, W., Zhou, J., Tripathi, M., Ko, N. S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20303-z · Cited by 125 · see citing works

Cytokines and STATs in Liver Fibrosis

Kong, X., Horiguchi, N., Mori, M., & Gao, B. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00069 · Cited by 113 · see citing works

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

Kagan, P., Sultan, M., Tachlytski, I., Safran, M., & Ben‐Ari, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176173 · Cited by 100 · see citing works

Inflammation and liver tumorigenesis

Sun, B., & Karin, M. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0256-4 · Cited by 88 · see citing works

Interleukin-6 Is an Important Mediator for Mitochondrial DNA Repair After Alcoholic Liver Injury in Mice

Zhang, X., Tachibana, S., Wang, H., Hisada, M., Williams, G. M., Gao, B., & Sun, Z. (2010) · Hepatology · doi:10.1002/hep.23909 · Cited by 73 · see citing works

Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice

Fourcot, A., Couchie, D., Chobert, M.-N., Zafrani, E., Mavier, P., Laperche, Y., & Brouillet, A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00311.2010 · Cited by 69 · see citing works

STAT3 in hepatocellular carcinoma: new perspectives

Svinka, J., Mikulits, W., & Eferl, R. (2014) · Hepatic Oncology · doi:10.2217/hep.13.7 · Cited by 63 · see citing works

Hepatitis C virus induced insulin resistance impairs response to anti viral therapy

El‐Zayadi, A. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i3.212 · Cited by 67 · see citing works

JAK-STAT signaling in hepatic fibrosis

Mair, M. (2011) · Frontiers in bioscience · doi:10.2741/3886 · Cited by 63 · see citing works

Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis

Henkel, J., Gärtner, D., Dorn, C., Hellerbrand, C., Schanze, N., Elz, S. R., & Püschel, G. P. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.47 · Cited by 65 · see citing works

Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice

Tsuchiya, H., Ikeda, Y., Ebata, Y., Kojima, C., Katsuma, R., Tsuruyama, T., Sakabe, T., Shomori, K., Komeda, N., Oshiro, S., et al. (2012) · Hepatology · doi:10.1002/hep.25798 · Cited by 63 · see citing works

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Hu, W., Lv, J., Han, M., Yang, Z. P., Li, T. X., Jiang, S., & Yang, Y. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.002 · Cited by 63 · see citing works

The Stat3 paradox: A killer and an oncogene

Resemann, H. K., Watson, C. J., & Lloyd‐Lewis, B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.029 · Cited by 58 · see citing works

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

Widjaja, A. A., Chothani, S. P., & Cook, S. A. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1761203 · Cited by 54 · see citing works

Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice

Cai, X., Fang, C., Hayashi, S., Hao, S., Zhao, M., Tsutsui, H., Nishiguchi, S., & Sheng, J. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-015-1154-0 · Cited by 55 · see citing works

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-Fed db/db mice

Yamaguchi, K., Itoh, Y., Yokomizo, C., Nishimura, T., Niimi, T., Umemura, A., Fujii, H., Okanoue, T., & Yoshikawa, T. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.2 · Cited by 54 · see citing works

Metformin increases hepatic leptin receptor and decreases steatosis in mice

Tang, X., Li, J., Xiang, W., Cui, Y., Xie, B., Wang, X., Xu, Z., & Gan, L. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0142 · Cited by 54 · see citing works

Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis

He, S., Luo, Y., Ma, W., Wang, X. Y., Yan, C., Hao, W., Fang, Y., Su, H., Lai, B., Liu, J., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.02.032 · Cited by 53 · see citing works

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease

Fang, C., Cai, X., Hayashi, S., Hao, S., Sakiyama, H., Wang, X., Yang, Q., Akira, S., Nishiguchi, S., Fujiwara, N., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.12.003 · Cited by 52 · see citing works

Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

Nagata, N., Matsuo, K., Bettaieb, A., Bakke, J., Matsuo, I., Graham, J. L., Xi, Y., Liu, S., Tomilov, A. A., Tomilova, N. B., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1406 · Cited by 50 · see citing works

Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high fat diet-induced steatosis in IL-6 deficient mice

Vida, M., Gavito, A., Pavón, F. J., Bautista, D., Serrano, A., Suárez, J., Arrabal, S., Decara, J. M., Cuevas, M. R., de Fonseca, F. R., et al. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.019166 · Cited by 50 · see citing works

Lack of fibroblast growth factor 21 accelerates metabolic liver injury characterized by steatohepatities in mice.

Liu, X., Zhang, P., Martin, R. C. G., Cui, G., Wang, G., Tan, Y., Cai, L., Lv, G., & Li, Y. (2016) · PubMed Central · Cited by 50 · see citing works

IL-6 and diabetic kidney disease

Zhang, L., Xu, F., & Hou, L.-Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465625 · Cited by 50 · see citing works

Preventive effects of interleukin-6 in lipopolysaccharide/ d -galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages

Li, L., Duan, C., Zhao, Y., Zhang, X., Yin, H., Wang, T., Huang, C., Liu, S., Yang, S., & Li, X. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.009 · Cited by 47 · see citing works

Organokines in disease

(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46 · see citing works

Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease

Min, H.-K., Mirshahi, F., Verdianelli, A., Pacana, T., Patel, V., Park, C.-G., Choi, A., Lee, J.-H., Park, C.-B., Ren, S., et al. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00390.2014 · Cited by 45 · see citing works

The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway

Collura, K. M., Niu, J., Sanders, S. S., Montersino, A., Holland, S. M., & Thomas, G. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013815 · Cited by 39 · see citing works

A Protective Role for CD154 in Hepatic Steatosis in Mice

Villeneuve, J., Lepreux, S., Mulot, A., Bérard, A. M., Higa-Nishiyama, A., Costet, P., de Lédinghen, V., Bioulac‐Sage, P., Balabaud, C. P., Nurden, A. T., et al. (2010) · Hepatology · doi:10.1002/hep.23935 · Cited by 35 · see citing works

The role of the interleukin family in liver fibrosis

Zhang, Z., Wang, J., Li, H., Niu, Q. F., Tao, Y., Zhao, X., Zeng, Z., & Dong, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1497095 · Cited by 34 · see citing works

Carbenoxolone ameliorates hepatic lipid metabolism and inflammation in obese mice induced by high fat diet via regulating the JAK2/STAT3 signaling pathway

Chen, Y., Wen, L., Jin, Z., Yu, J., & Shi, B. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.03.011 · Cited by 34 · see citing works

Role of insulin resistance and hepatic steatosis in the progression of fibrosis and response to treatment in hepatitis C

Sanyal, A. J. (2011) · Liver International · doi:10.1111/j.1478-3231.2010.02397.x · Cited by 34 · see citing works

Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms

Nelson, J. E., Handa, P., Aouizerat, B. E., Wilson, L., Vemulakonda, L. A., Yeh, M. M., & Kowdley, K. V. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13824 · Cited by 33 · see citing works

Interaction mechanisms between major depressive disorder and non-alcoholic fatty liver disease

Shao, Q., Wu, Y., Ji, J., Xu, T., Yu, Q., Ma, C., Liao, X., Cheng, F., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711835 · Cited by 32 · see citing works

Immunoregulation by lipids during the development of non-alcoholic steatohepatitis.

Ramadori, P., Kroy, D. C., & Streetz, K. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.01.02 · Cited by 32 · see citing works

Stem cell exosomes: new hope and future potential for relieving liver fibrosis

Li, L., Liu, Y., Wang, K., Mo, J., Weng, Z., Jiang, H., & Jin, C. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0854 · Cited by 30 · see citing works

A novel STAT3 inhibitor, STX-0119, attenuates liver fibrosis by inactivating hepatic stellate cells in mice

Choi, S., Jung, H. J., Kim, M. W., Kang, J., Shin, D., Jang, Y., Yoon, Y. S., & Oh, S. H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.156 · Cited by 29 · see citing works

Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice

Gavito, A., Bautista, D., Suárez, J., Badran, S., Arco, R., Pavón, F., Serrano, A., Rivera, P., Decara, J., Cuesta, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157956 · Cited by 26 · see citing works

Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling

Zhao, J., Jiao, Y., Song, Y., Liu, J., Li, X., Zhang, H., Yang, J., & Lu, Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00873 · Cited by 25 · see citing works

iRhom2 inhibits bile duct obstruction–induced liver fibrosis

Sundaram, B., Behnke, K., Belancic, A., Al-Salihi, M. A., Thabet, Y., Polz, R., Pellegrino, R., Zhuang, Y., Shinde, P. V., Xu, H. C., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aax1194 · Cited by 20 · see citing works

SULF1/SULF2 reactivation during liver damage and tumour growth

Graham, K., Murphy, J. I., & Dhoot, G. K. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1425-8 · Cited by 19 · see citing works

Inflammatory networks cultivate cancer cell metastasis to the liver

Lee, J. W., & Beatty, G. L. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1728013 · Cited by 17 · see citing works

The research development of STAT3 in hepatic ischemia-reperfusion injury

Yang, H., Zhang, P., Wang, Q., Cheng, K., & Zhao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1066222 · Cited by 16 · see citing works

Effect of adipocyte-secreted factors on EpCAM+/CD133+ hepatic stem cell population

Karagonlar, Z. F., Koç, D., Şahin, E., Avcı, S. T., Yilmaz, M., Atabey, N., & Erdal, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.137 · Cited by 14 · see citing works

Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3

Cho, I. J., Kim, J. K., Kim, E. O., Park, S. M., Kim, S. C., Ki, S. H., & Ku, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094743 · Cited by 13 · see citing works

New Approaches for Studying Alcoholic Liver Disease

Xu, J., Liu, X., Gao, B., Karin, M., Tsukamoto, H., Brenner, D. A., & Kisseleva, T. (2014) · Current Pathobiology Reports · doi:10.1007/s40139-014-0053-z · Cited by 13 · see citing works

Early inflammation–associated factors blunt sterol regulatory element‐binding proteins‐1‐mediated lipogenesis in high‐fat diet‐fed APPSWE/PSEN1dE9 mouse model of Alzheimer's disease

Tang, Y., Peng, Y., Liu, J., Shi, L., Wang, Y., Long, J., & Liu, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13437 · Cited by 13 · see citing works

Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Kraakman, M. J., Peijs, L., Rose‐John, S., & Febbraio, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179099 · Cited by 12 · see citing works

The role of ADAM17 during liver damage

Al-Salihi, M. A., Bornikoel, A., Zhuang, Y., Stachura, P., Scheller, J., Lang, K. S., & Lang, P. A. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0149 · Cited by 11 · see citing works

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency

Cho, K., Ushiki, T., Ishiguro, H., Tamura, S., Araki, M., Suwabe, T., Katagiri, T., Watanabe, M., Fujimoto, Y., Ohashi, R., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103117 · Cited by 11 · see citing works

Low-dose valine attenuates diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice by enhancing leptin sensitivity and modulating the gut microbiome

Felicianna, Lo, E. K. K., Chen, C., Ismaiah, M. J., Zhang, F., Leung, H. K. M., & El-Nezami, H. S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102059 · Cited by 9 · see citing works

Refining MASLD Phenotypes: Clinical, Metabolic, and Elastographic Differences Between Adipose Tissue Dysfunction and Obesity-Driven Disease

Cosma, T., Avram, L., Donca, V., Grosu, A. I., Stoicescu, L., Buzdugan, E., Nemeș, A., Bălan, A. M., & Crișan, D. (2025) · Nutrients · doi:10.3390/nu17243940 · Cited by 9 · see citing works

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury

Dong, J., Lim, W., Shekeran, S. G., Tan, J., Lim, S. Y., Goh, J. W. T., George, B. L., Schäfer, S., Cook, S. A., & Widjaja, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137089 · Cited by 9 · see citing works

SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice

Tran, M., Mostofa, G., Picard, M., Wu, J., Wang, L., & Shin, D. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0073 · Cited by 7 · see citing works

Proteomic and phosphoproteomic analysis reveal threonine deficiency increases hepatic lipid deposition in Pekin ducks via reducing STAT phosphorylation

Jiang, Y. Q., Zhuang, Z., Jia, W., Wen, Z., Xie, M., Bai, H., Bi, Y., Wang, Z., Chang, G., Hou, S., et al. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.01.008 · Cited by 6 · see citing works

CD40 signaling and hepatic steatosis: Unanticipated links

Lepreux, S., Villeneuve, J., Dewitte, A., Bérard, A. M., Desmoulière, A., & Ripoche, J. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2016.11.002 · Cited by 5 · see citing works

Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and Fibrosis during Cholestatic Injury

Hubel, E., Neumann, A., Fishman, S., Schaffer, O., Erez, N., Shrkihe, B. A., Shteingard, Y., Gross, T., Shibolet, O., Varol, C., et al. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.01.023 · Cited by 4 · see citing works

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

Sato, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-68613-2 · Cited by 4 · see citing works

Differential Role of gp130-Dependent STAT and Ras Signalling for Haematopoiesis Following Bone-Marrow Transplantation

Kroy, D. C., Hebing, L., Sander, L. E., Gaßler, N., Erschfeld, S., Sackett, S. D., Galm, O., Trautwein, C., & Streetz, K. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039728 · Cited by 3 · see citing works

Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis

Tu, T., Alba, M. M., Datta, A. A., Hong, H., Hua, B., Jia, Y., Khan, J., Nguyen, P., Niu, X., Pammidimukkala, P., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.958696 · Cited by 3 · see citing works

IL-6 in non-alcoholic fatty liver disease – good, evil or both?

Buechler, C. (2012) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000e101 · Cited by 3 · see citing works

Impact of Cytokines in Hepatocellular Carcinoma Initiation and Progression

Ahmed, Y. A., & Lafdil, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-64958-0_9 · Cited by 1 · see citing works

Signaling Pathways in the Liver

Lade, A. G., & Monga, S. P. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_20 · Cited by 1 · see citing works

the Chicken or the Egg: Adipocytes and Hepatic Insulin Resistance

Hebbard, L., & George, J. (2010) · Hepatology · doi:10.1002/hep.23580 · Cited by 1 · see citing works

Studies on the mechanisms of action and physiological relevance of SOCS proteins

Zadjali, F. (2011) · Figshare

Identification of Shared Gene Signatures in Different Stages of Non-Alcoholic Fatty Liver Disease Using Integrated Microarray DatasetPreprint

Gh, B. F. N. M., & Arabfard, M. (2020) · Research Square · doi:10.21203/rs.3.rs-130713/v1

Current World Literature

(2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328347aeca

Rôle de la protéine Gas6 et des cellules précurseurs dans la stéatohépatite et la fibrose hépatique

Fourcot, A. (2010) · theses.fr (ABES) · doi:10.70675/cfa04fd7z7fc5z4de1za21azd888d9c26d9b

HGF,c-Met and IL-6,gp130 mediated signalling pathways in a model of acute and chronic cholestatic liver injury in mice

Giebeler, A., & Spehr, M. (2011) · RWTH Publications (RWTH Aachen)

941 SERUM PROHEPCIDIN LEVELS IN HEALTHY ADULTS, NONALCOHOLIC FATTY LIVER, CHRONIC HEPATITIS C AND ALCOHOLIC LIVER DISEASE: SIGNIFICANT ELEVATION IN CHRONIC HEPATITIS C PATIENTS

Lee, S. H., Jeong, S., Shin, S., Lee, J. H., Park, Y. S., Hwang, J.-H., Kim, J.-W., Kim, N. Y., Lee, D. H., & Park, K. U. (2008) · Journal of Hepatology · doi:10.1016/s0168-8278(08)60943-5

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice

Yamaguchi, K., Itoh, Y., Yokomizo, C., Nishimura, T., Niimi, T., Fujii, H., Okanoue, T., & Yoshikawa, T. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.75 · Cited by 125 · see citing works

Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Kraakman, M. J., Peijs, L., Rose‐John, S., & Febbraio, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179099 · Cited by 12 · see citing works

Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10–deficient mice

Miller, A. M., Wang, H., Bertola, A., Park, O., Horiguchi, N., Ki, S. H., Yin, S., Lafdil, F., & Gao, B. (2011) · Hepatology · doi:10.1002/hep.24517 · Cited by 162 · see citing works

Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis

Plum, W., Tschaharganeh, D. F., Kroy, D. C., Corsten, E., Erschfeld, S., Dierssen, U., Wasmuth, H. E., Trautwein, C., & Streetz, K. L. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090469 · Cited by 51 · see citing works