Sharpless, Norman E.

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

Li, W., Asokan, A., Wu, Z., Van Dyke, T., DiPrimio, N., Johnson, J. S., Govindaswamy, L., Agbandje-McKenna, M., Leichtle, S., Eugene Redmond Jr, D., et al. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 261

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

Min, J.-N., Whaley, R. A., Sharpless, N. E., Lockyer, P., Portbury, A. L., & Patterson, C. (2008) · Molecular and Cellular Biology

Genetics, Aging, and Longevity in Model OrganismsHeat shock proteins research

Cited by 256

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

Roberts, P. J., Bisi, J. E., Strum, J. C., Combest, A. J., Darr, D. B., Usary, J. E., Zamboni, W. C., Wong, K.-K., Perou, C. M., & Sharpless, N. E. (2012) · JNCI Journal of the National Cancer Institute

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 255

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Mohlke, K. L., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · PLoS ONE

Genetic Associations and EpidemiologyAtherosclerosis and Cardiovascular Diseases

Cited by 248

ROS as a tumour suppressor?

Ramsey, M. R., & Sharpless, N. E. (2006) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceRedox biology and oxidative stress

Cited by 237

The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., & DePinho, R. A. (2004) · Oncogene

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 224

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

Souroullas, G. P., Jeck, W. R., Parker, J. S., Simon, J. M., Liu, J.-Y., Paulk, J., Xiong, J., Clark, K. S., Fedoriw, Y., Qi, J., et al. (2016) · Nature Medicine

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 212

Review: a meta‐analysis of GWAS and age‐associated diseases

Jeck, W. R., Siebold, A. P., & Sharpless, N. E. (2012) · Aging Cell

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 204

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

Johnson, S. M., Torrice, C. D., Bell, J. F., Monahan, K. B., Jiang, Q., Wang, Y., Ramsey, M. R., Jin, J., Wong, K.-K., Su, L., et al. (2010) · Journal of Clinical Investigation

Effects of Radiation ExposureHematopoietic Stem Cell Transplantation

Cited by 168

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Shao, L., Feng, W., Li, H., Gardner, D., Luo, Y., Wang, Y., Liu, L., Meng, A., Sharpless, N. E., & Zhou, D. (2014) · Blood

Hematopoietic Stem Cell TransplantationEffects of Radiation Exposure

Cited by 165

Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

Diekman, B. O., Sessions, G. A., Collins, J. A., Knecht, A. K., Strum, S. L., Mitin, N. K., Carlson, C. S., Loeser, R. F., & Sharpless, N. E. (2018) · Aging Cell

Telomeres, Telomerase, and SenescenceOsteoarthritis Treatment and Mechanisms

Cited by 158

Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 142

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Kim, W. Y., Perera, S., Zhou, B., Carretero, J., Yeh, J. J., Heathcote, S. A., Jackson, A. L., Nikolinakos, P., Ospina, B., Naumov, G., et al. (2009) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 141

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Zhang, H., Fillmore Brainson, C., Koyama, S., Redig, A. J., Chen, T., Li, S., Gupta, M., Garcia-de-Alba, C., Paschini, M., Herter-Sprie, G. S., et al. (2017) · Nature Communications

Epigenetics and DNA MethylationCancer Cells and Metastasis

Cited by 127

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Liu, W., Monahan, K. B., Pfefferle, A. D., Shimamura, T., Sorrentino, J., Chan, K. T., Roadcap, D. W., Ollila, D. W., Thomas, N. E., Castrillon, D. H., et al. (2012) · Cancer Cell

Cancer Cells and MetastasisMelanoma and MAPK Pathways

Cited by 127

Expression of p16INK4a prevents cancer and promotes aging in lymphocytes

Liu, Y., Johnson, S. M., Fedoriw, Y., Rogers, A. B., Yuan, H., Krishnamurthy, J., & Sharpless, N. E. (2011) · Blood

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

A Blueprint for Characterizing Senescence

Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N., Hodes, R. J., Wilder, E. L., & Anderson, J. M. (2020) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

Kuo, C.-L., Murphy, A. J., Sayers, S., Li, R., Yvan-Charvet, L., Davis, J. Z., Krishnamurthy, J., Liu, Y., Puig, O., Sharpless, N. E., et al. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 73

Expression of p16INK4a as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy

Nelson, J. A. E., Krishnamurthy, J., Menezes, P., Liu, Y., Hudgens, M. G., Sharpless, N. E., & Eron, J. J. (2012) · Aging Cell

HIV Research and TreatmentTelomeres, Telomerase, and Senescence

Cited by 66

Defective Cell Cycle Checkpoint Functions in Melanoma Are Associated with Altered Patterns of Gene Expression

Kaufmann, W. K., Nevis, K. R., Qu, P., Ibrahim, J. G., Zhou, T., Zhou, Y., Simpson, D. A., Helms-Deaton, J., Cordeiro-Stone, M., Moore, D. T., et al. (2008) · Journal of Investigative Dermatology

DNA Repair MechanismsMelanoma and MAPK Pathways

Cited by 65

Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF

Sarkar-Agrawal, P., Vergilis, I., Sharpless, N. E., DePinho, R. A., & Runger, T. M. (2004) · JNCI Journal of the National Cancer Institute

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 48

Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults

Pustavoitau, A., Barodka, V., Sharpless, N. E., Torrice, C., Nyhan, D., Berkowitz, D. E., Shah, A. S., Bandeen Roche, K. J., & Walston, J. D. (2016) · Experimental Gerontology

Cardiac and Coronary Surgery TechniquesTelomeres, Telomerase, and Senescence

Cited by 36