Ink4a/Arf links senescence and aging

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Expression of senescence-related genes in human corneal endothelial cells.

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p16INK4a: A central player in cellular senescence and a promising aging biomarker in elderly cancer patients

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The role of TEMRA cell-mediated immune senescence in the development and treatment of HIV disease

Guo, L., Liu, X., & Su, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1284293 · Cited by 34 · see citing works

Proteomic analysis of p16ink4a‐binding proteins

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Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1

Lee, T. X. Y., Wu, J., Jean, W., Condello, G., AlKhatib, A. H., Hsieh, C.-C., Hsieh, Y., Huang, C., & Kuo, C. (2021) · Aging · doi:10.18632/aging.203176 · Cited by 33 · see citing works

Effects of Bifidobacterium bifidum on adaptive immune senescence in aging mice

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Genetic Variation and Human Aging: Progress and Prospects

Melzer, D. R., Hurst, A. J., & Frayling, T. M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.301 · Cited by 34 · see citing works

Mechanism of impairment on liver regeneration in elderly patients: Role of hepatic stellate cell function

Saito, Y., Morine, Y., & Shimada, M. (2017) · Hepatology Research · doi:10.1111/hepr.12872 · Cited by 31 · see citing works

Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts

Young, J. J., Patel, A., & Rai, P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.026 · Cited by 31 · see citing works

TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation

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Bmi1 Distinguishes Immature Retinal Progenitor/Stem Cells from the Main Progenitor Cell Population and Is Required for Normal Retinal Development

Chatoo, W., Abdouh, M., Duparc, R.-H., & Bernier, G. (2010) · Stem Cells · doi:10.1002/stem.462 · Cited by 31 · see citing works

Senescence and life span

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Cisplatin-Induced Senescence and Growth Inhibition in Human Non-Small Cell Lung Cancer Cells With Ectopic Transfer of p16I NK4a

Fang, K., Chiu, C., Li, C.-H., Chang, Y.-T., & Hwang, H.-T. (2007) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504007783338331 · Cited by 29 · see citing works

The Intricate Interplay between Mechanisms Underlying Aging and Cancer

Piano, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0209 · Cited by 28 · see citing works

Major heat shock protein Hsp72 controls oncogene‐induced senescence

Sherman, M. Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05196.x · Cited by 28 · see citing works

Overexpression of the Cell Cycle Inhibitor p16 INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice

Cardenas, J. C., Owens, A. P., Krishnamurthy, J., Sharpless, N. E., Whinna, H. C., & Church, F. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221721 · Cited by 27 · see citing works

The Molecular Pathogenesis of Gastrointestinal Stromal Tumors

Tarn, C., & Godwin, A. K. (2006) · Clinical Colorectal Cancer · doi:10.3816/ccc.2006.s.002 · Cited by 27 · see citing works

Oxidants, metabolism, and stem cell biology

Liu, J., Cao, L., & Finkel, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.434 · Cited by 26 · see citing works

Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a

Huang, X., Shi, Z., Wang, W., Bai, J., Chen, Z., Xu, J., Zhang, D., & Fu, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.181 · Cited by 26 · see citing works

Molecular evidence of senescence in corneal endothelial cells of senescence-accelerated mice.

Xiao, X., Wang, Y., Gong, H., Chen, P., & Xie, L. (2009) · PubMed Central · Cited by 23 · see citing works

Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress

Chen, J., & Ozanne, S. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.023 · Cited by 24 · see citing works

Genetic Regulation of Thymocyte Progenitor Aging

Berent-Maoz, B., Montecino-Rodriguez, E., & Dorshkind, K. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.006 · Cited by 26 · see citing works

How Long Will My Mouse Live? Machine Learning Approaches for Prediction of Mouse Life Span

Swindell, W. R., Harper, J. M., & Miller, R. A. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.9.895 · Cited by 22 · see citing works

Human genetic variations: Beacons on the pathways to successful ageing

Cluett, C., & Melzer, D. R. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.009 · Cited by 22 · see citing works

Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions

Proshkina, E., Solovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2020) · Molecular Biology · doi:10.1134/s0026893320060096 · Cited by 21 · see citing works

Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies

MacDonald, J. A., Bradshaw, G. A., Jochems, F., Bernards, R., & Letai, A. G. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-024-01431-1 · Cited by 21 · see citing works

Liver Regeneration: Changes in Oxidative Stress, Immune System, Cytokines, and Epigenetic Modifications Associated with Aging

Tang, C., Chen, H., Jiang, L., & Liu, L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9018811 · Cited by 19 · see citing works

Mitogen‐activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage‐mediated formation of senescence‐associated heterochromatic foci in tumour cells

Zhang, Y., Gao, Y., Zhao, L., Han, L., Lu, Y., Hou, P., Shi, X., Liu, X., Tian, B., Wang, X., et al. (2013) · FEBS Journal · doi:10.1111/febs.12435 · Cited by 19 · see citing works

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype

Engler, M., Fidan, M., Nandi, S., & Cirstea, I. C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111411 · Cited by 15 · see citing works

Neosis - A Parasexual Somatic Reduction Division in Cancer

Rajaraman, R., Guernsey, D. L., Rajaraman, M. M., & Rajaraman, S. R. (2007) · International Journal of Human Genetics · doi:10.1080/09723757.2007.11885983 · Cited by 18 · see citing works

Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции

Proshkina, E., Соловьёв, И. А., Shaposhnikov, M. V., & Moskalev, A. A. (2020) · Molecular Biology · doi:10.31857/s0026898420060099 · Cited by 18 · see citing works

Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia

Signer, R. A. J., Montecino‐Rodriguez, E., Witte, O. N., & Dorshkind, K. A. (2010) · Blood · doi:10.1182/blood-2010-01-264093 · Cited by 17 · see citing works

Involvement of the INK4a/Arf gene locus in senescence

Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113 · see citing works

p16 and ARF: activation of teenage proteins in old age

Ande, S., & Rudolph, K. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23437 · Cited by 64 · see citing works

Ink4a/Arf expression is a biomarker of aging

Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works

Ink4‐Arf locus in cancer and aging

Sherr, C. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.40 · Cited by 100 · see citing works

The Regulation of INK4/ARF in Cancer and Aging

Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · see citing works