Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults
Open accessAbstract
Adults older than 65 years undergo more than 120,000 coronary artery bypass (CAB) procedures each year in the United States. Chronological age alone, though commonly used in prediction models of outcomes after CAB, does not alone reflect variability in aging process; thus, the risk of complications in older adults. We performed a prospective study to evaluate a relationship between senescence marker p16(INK4a) expression in peripheral blood T-lymphocytes (p16 levels in PBTLs) with aging and with perioperative outcomes in older CAB patients. We included 55 patients age 55 and older, who underwent CAB in Johns Hopkins Hospital between September 1st, 2010 and March 25th, 2013. Demographic, clinical and laboratory data following outline of the Society of Thoracic Surgeons data collection form was collected, and p16 mRNA levels in PBTLs were measured using TaqMan® qRT-PCR. Associations between p16 mRNA levels in PBTLs with length of hospital stay, frailty status, p16 protein levels in the aortic and left internal mammary artery tissue, cerebral oxygen saturation, and augmentation index as a measure of vascular stiffness were measured using regression analyses. Length of hospital stay was the primary outcome of interest, and major organ morbidity, mortality, and discharge to a skilled nursing facility were secondary outcomes. In secondary analysis, we evaluated associations between p16 mRNA levels in PBTLs and interleukin-6 levels using regression analyses. Median age of enrolled patients was 63.5 years (range 56-81 years), they were predominantly male (74.55%), of Caucasian descent (85.45%). Median log2(p16 levels in PBTLs) were 4.71 (range 1.10-6.82). P16 levels in PBTLs were significantly associated with chronological age (mean difference 0.06 for each year increase in age, 95% CI 0.01-0.11) and interleukin 6 levels (mean difference 0.09 for each pg/ml increase in IL-6 levels, 95% CI 0.01-0.18). There were no significant associations with frailty status, augmentation index, cerebral oxygenation and p16 protein levels in blood vessels. Increasing p16 levels in PBTLs did not predict length of stay in the hospital (HR 1.10, 95% CI 0.87-1.40) or intensive care unit (HR 1.02, 95% CI 0.79-1.32). Additional evaluation of p16 levels in PBTLs as predictor of perioperative outcomes is required and should include additional markers of immune system aging as well as different outcomes after CAB in addition to length of hospital stay.
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T cell p16 levels forecast how long older adults stay in hospital after coronary artery bypass surgery.
“to predict length of hospital stay after coronary artery bypass surgery in older adults31.”
From Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial (2024) · cites this paper as [31]
The Results (§3.5) report no association between T-cell p16INK4a levels and hospital length of stay after coronary artery bypass surgery (HR 1.10, 95% CI 0.87–1.40; p=0.49). The Abstract likewise says increasing p16 levels did not predict hospital stay, contrary to the claim. (LLM, conf=0.95)
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Experimental — accuracy not yet measuredIn 47 patients aged 56-81 yr with a high prevalence of frailty and comorbid conditions undergoing coronary artery bypass surgery, no association was found between levels of physical activity and P16 in circulating T cells.
“In a recent study of 47 patients aged 56–81 yr with a high prevalence of frailty and comorbid conditions undergoing coronary artery bypass surgery, no association was found between levels of physical activity and P16 in circulating T cells (63).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [63]
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- Authors
- Pustavoitau, A., Barodka, V., Sharpless, N. E., Torrice, C., Nyhan, D., Berkowitz, D. E., Shah, A. S., Bandeen Roche, K. J., & Walston, J. D.
- Affiliations
- Johns Hopkins University (US)
- University of North Carolina at Chapel Hill (US)
- Vanderbilt University (US)
- Corresponding author
- Pustavoitau, Aliaksei
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 74
- Pages
- 29-36
- ISSN
- 0531-5565 (ISSN-L)
- PMC
- PMC4718794
- OpenAlex
- W2190975361
- Cited by
- 36
- References
- 40
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2016: 5
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-02-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Johns Hopkins University (P30AG021334)
- National Institutes of Health (5r01ag024379-15, UL1TR001079)
- National Institute on Aging (R01-AG024379, P30AG021334)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- p16INK4a, cellular senescence, coronary artery bypass grafting, older adults, length of hospital stay, T cells, frailty, interleukin-6, vascular stiffness, perioperative outcomes, aging biomarkers, postoperative complications, mortality, cerebral oxygen saturation, augmentation index
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Coronary Artery Bypass, Coronary Artery Disease, Female, Genetic Markers, Humans, Length of Stay, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Prospective Studies, Risk Factors, RNA, Messenger, T-Lymphocytes, Time Factors, Baltimore, Geriatric Assessment, Interleukin-6, Polymerase Chain Reaction, Frail Elderly, Treatment Outcome, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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