Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
Open accessAbstract
Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a multistage pathway to squamous carcinoma. We report that infiltration by mast cells and activation of the matrix metalloproteinase MMP-9/gelatinase B coincides with the angiogenic switch in premalignant lesions. Mast cells infiltrate hyperplasias, dysplasias, and invasive fronts of carcinomas, but not the core of solid tumors, where they degranulate in close apposition to capillaries and epithelial basement membranes, releasing mast-cell-specific serine proteases MCP-4 (chymase) and MCP-6 (tryptase). MCP-6 is shown to be a mitogen for dermal fibroblasts that proliferate in the reactive stroma, whereas MCP-4 can activate progelatinase B and induce hyperplastic skin to become angiogenic in an in vitro bioassay. Notably, premalignant angiogenesis is abated in a mast-cell-deficient (KITW/KITWWv) HPV16 transgenic mouse. The data indicate that neoplastic progression in this model involves exploitation of an inflammatory response to tissue abnormality. Thus, regulation of angiogenesis during squamous carcinogenesis is biphasic: In hyperplasias, dysplasias, and invading cancer fronts, inflammatory mast cells are conscripted to reorganize stromal architecture and hyperactivate angiogenesis; within the cancer core, upregulation of angiogenesis factors in tumor cells apparently renders them self-sufficient at sustaining neovascularization.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines.
“Genetic and functional experiments indicate that neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines11,23–26.”
From Inflammation and cancer (2002) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885 · see citing works
Self-citationWhat Is the Evidence That Tumors Are Angiogenesis Dependent?
Folkman, J. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.4 · Cited by 4,509 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works
RAG-1-deficient mice have no mature B and T lymphocytes
Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works
Proteins: Structures and Molecular Properties
Creighton, T. E. (1986) · Medical Entomology and Zoology · Cited by 2,652 · see citing works
Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,737 · see citing works
Self-citationThe proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P., & Bernstein, A. (1988) · Nature · doi:10.1038/335088a0 · Cited by 1,339 · see citing works
Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation
Kitamura, Y., Go, S.-R., & Hatanaka, K. (1978) · Blood · doi:10.1182/blood.v52.2.447.bloodjournal522447 · Cited by 830 · see citing works
Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation
Kitamura, Y., Go, S.-R., & Hatanaka, K. (1978) · Blood · doi:10.1182/blood.v52.2.447.447 · Cited by 651 · see citing works
Whitelock, J. M., Murdoch, A. D., Iozzo, R. V., & Underwood, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10079 · Cited by 597 · see citing works
Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2
Molino, M., Barnathan, E. S., Numerof, R. P., Clark, J., Dreyer, M. L., Cumashi, A., Hoxie, J. A., Schechter, N. M., Woolkalís, M. J., & Brass, L. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4043 · Cited by 591 · see citing works
Nocka, K. H., Tan, J. C., Chiu, E., Chu, T., Ray, P., Traktman, P., & Besmer, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08305.x · Cited by 588 · see citing works
Matrix metal loproteinases and the development of cancer
Coussens, L. M., & Werb, Z. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90178-7 · Cited by 569 · see citing works
Self-citationHerron, G. S., Banda, M. J., Clark, E. J., Gavrilović, J., & Werb, Z. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35860-x · Cited by 525 · see citing works
Self-citationVEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix
Gluzman‐Poltorak, Z., Cohen, T., Sivan, R., Kandelis, Y., Spira, G., Vlodavsky, I., Keshet, E., & Neufeld, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7151 · Cited by 519 · see citing works
VUORIO, E. I., & Crombrugghe, B. D. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.004201 · Cited by 513 · see citing works
Landscaping the Cancer Terrain
Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.280.5366.1036 · Cited by 511 · see citing works
Brown, L. F., Detmar, M. J., Claffey, K. P., Nagy, J. A., Feng, D., Dvořàk, A. M., & Dvorak, H. F. (1997) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-9006-9_10 · Cited by 472 · see citing works
How does extracellular matrix control capillary morphogenesis?
Ingber, D. E., & Folkman, J. (1989) · Cell · doi:10.1016/0092-8674(89)90928-8 · Cited by 462 · see citing works
Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor.
Blair, R. J., Meng, H., Marchese, M. J., Ren, S., Schwartz, L. B., Tonnesen, M. G., & Gruber, B. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119458 · Cited by 434 · see citing works
Grützkau, A., Krüger‐Krasagakes, S., Baumeister, H., Schwarz, C., Koegel, H., Welker, P., Lippert, U., Henz, B. M., & Möller, A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.4.875 · Cited by 336 · see citing works
Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
Cairns, J. A., & Walls, A. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119290 · Cited by 318 · see citing works
Molecular and functional aspects of PECAM-1/CD31
DeLisser, H. M., Newman, P. J., & Albelda, S. Μ. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90195-3 · Cited by 316 · see citing works
Gruber, B. L., Kew, R. R., Jelaska, A., Marchese, M. J., Garlick, J. A., Ren, S., Schwartz, L. B., & Korn, J. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2310 · Cited by 309 · see citing works
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice
Arbeit, J. M., Münger, K., Howley, P. M., & Hanahan, D. (1994) · Journal of Virology · doi:10.1128/jvi.68.7.4358-4368.1994 · Cited by 304 · see citing works
Self-citationVlodavsky, I., Eldor, A., Haimovitz‐Friedman, A., Matzner, Y., Ishai-Michaeli, R., Lider, O., Naparstek, Y., Cohen, I. R., & FUKS, Z. Y. (1992) · PubMed · Cited by 302 · see citing works
Mucosal mast cells. I. Isolation and functional characteristics of rat intestinal mast cells.
Befus, A. D., Pearce, F. L., Gauldie, J., Horsewood, P., & Bienenstock, J. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.6.2475 · Cited by 289 · see citing works
Hanahan, D., Christofori, G., Naik, P., & Arbeit, J. M. (1996) · European Journal of Cancer · doi:10.1016/s0959-8049(96)00401-7 · Cited by 253 · see citing works
Self-citationDemonstration and characterization of the angiogenic properties of cervical dysplasia.
Smith‐McCune, K., & Weidner, N. (1994) · PubMed · Cited by 235 · see citing works
Mast‐cell‐deficient W/Wv mice exhibit A decreased rate of tumor angiogenesis
Starkey, J. R., Crowle, P. K., & Taubenberger, S. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910420110 · Cited by 217 · see citing works
Herron, G. S., Werb, Z., Dwyer, K. S., & Banda, M. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35859-3 · Cited by 216 · see citing works
Self-citationBehrendtsen, O., Alexander, C. M., & Werb, Z. (1992) · Development · doi:10.1242/dev.114.2.447 · Cited by 216 · see citing works
Self-citationGenetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.
Coussens, L. M., Hanahan, D., & Arbeit, J. M. (1996) · PubMed · Cited by 205 · see citing works
Self-citationReynolds, D. S., Stevens, R. L., Lane, W. S., Carr, M., Austen, K. F., & Serafin, W. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.8.3230 · Cited by 203 · see citing works
Mast cell population density, blood vessel density and histamine content in normal human skin
Eady, R., Cowen, T., Marshall, T. F., Plummer, V., & Greaves, M. (1979) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1979.tb08065.x · Cited by 184 · see citing works
Matrix metalloproteinases in normal menstruation
Salamonsen, L. A., & Woolley, D. E. (1996) · Human Reproduction · doi:10.1093/humrep/11.suppl_2.124 · Cited by 178 · see citing works
Talhouk, R., Chin, J. R., Unemori, E., Werb, Z., & Bissell, M. J. (1991) · Development · doi:10.1242/dev.112.2.439 · Cited by 176 · see citing works
Self-citationThe multiple roles of tumour stroma
Wernert, N. (1997) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050053 · Cited by 168 · see citing works
Reynolds, D. S., Gurley, D. S., Austen, K. F., & Serafin, W. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67871-3 · Cited by 166 · see citing works
Conjugated avidin binds to mast cell granules.
Tharp, M. D., Seelig, L. L., Tigelaar, R. E., & Bergstresser, P. R. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.1.2578142 · Cited by 161 · see citing works
Thurston, G., Bałuk, P., Hirata, A., & McDonald, D. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.6.h2547 · Cited by 159 · see citing works
Fang, K. C., Raymond, W. W., Blount, J. L., & Caughey, G. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25628 · Cited by 156 · see citing works
Self-citationThe mast cell: origin, morphology, distribution, and function
Li, Y. (1997) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(97)80129-7 · Cited by 140 · see citing works
Exon skipping by mutation of an authentic splice site ofc-kitgene inW/Wmouse
Hayashi, S., Kunisada, T., Ogawa, M., Yamaguchi, K., & Nishikawa, S.-I. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.6.1267 · Cited by 140 · see citing works
Ohtani, H. (1998) · Pathology International · doi:10.1111/j.1440-1827.1998.tb03820.x · Cited by 129 · see citing works
Identification of a chymotrypsin-like proteinase in human mast cells.
Schechter, N. M., Choi, J. K., Slavin, D., Deresienski, D., 佐山, 重., Dong, G., Lavker, R. M., Proud, D., & Lazarus, G. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.3.962 · Cited by 127 · see citing works
Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases.
Stevens, R. L., Friend, D. S., McNeil, H. P., Schiller, V., Ghildyal, N., & Austen, K. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.128 · Cited by 127 · see citing works
Smith‐McCune, K., Zhu, Y. H., Hanahan, D., & Arbeit, J. M. (1997) · PubMed · Cited by 127 · see citing works
Self-citationDog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
Fang, K. C., Raymond, W. W., Lazarus, S. C., & Caughey, G. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118583 · Cited by 125 · see citing works
Self-citationThe role of fibroblasts in tumor behavior
Gr�goire, M., & Lieubeau, B. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690602 · Cited by 119 · see citing works
Human cutaneous mast cells express basic fibroblast growth factor.
Reed, J. A., Albino, A. P., & McNutt, N. S. (1995) · PubMed · Cited by 119 · see citing works
Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma
Dabbous, M. K., Walker, R. A., Haney, L., Carter, L. M., Nicolson, G. L., & Woolley, D. E. (1986) · British Journal of Cancer · doi:10.1038/bjc.1986.198 · Cited by 117 · see citing works
Natural Disruption of the Mouse Mast Cell Protease 7 Gene in the C57BL/6 Mouse
Hunt, J. E., Stevens, R. L., Austen, K. F., Zhang, J., Xia, Z., & Ghildyal, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2851 · Cited by 112 · see citing works
Huang, R., Blom, T., & Hellman, L. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210706 · Cited by 108 · see citing works
Friedl, A., Chang, Z., Tierney, A., & Rapraeger, A. C. (1997) · Europe PMC (PubMed Central) · Cited by 105 · see citing works
McNeil, H. P., Austen, K. F., Somerville, L. L., Gurish, M. F., & Stevens, R. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54925-5 · Cited by 103 · see citing works
Hartmann, T., Ruoss, S. J., Raymond, W. W., Seuwen, K., & Caughey, G. H. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.262.5.l528 · Cited by 93 · see citing works
Self-citationIncreased mast cell density in invasive melanoma
Duncan, L. M., Richards, L. A., & Mihm, M. C. (1998) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1998.tb01683.x · Cited by 92 · see citing works
Bergers, G., Hanahan, D., & Coussens, L. M. (1998) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9853830 · Cited by 89 · see citing works
Self-citationBernstein, A., Chabot, B., Dubreuil, P. C., Reith, A. D., Nocka, K. H., Majumder, S., Ray, P. N., & Besmer, P. (1990) · PubMed · Cited by 87 · see citing works
The chloroacetate esterase reaction
Leder, L.-D. (1979) · American Journal of Dermatopathology · doi:10.1097/00000372-197900110-00005 · Cited by 85 · see citing works
Molecular Regulation of Angiogenesis in the Skin
Detmar, M. J. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12340457 · Cited by 83 · see citing works
Ghildyal, N., Friend, D. S., Stevens, R. L., Austen, K. F., Huang, C. B., Penrose, J. F., Šali, A., & Gurish, M. F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1061 · Cited by 80 · see citing works
Cells Involved in the Immune Response
Richter, M., Rose, B., & Abdou, N. I. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000230280 · Cited by 79 · see citing works
Bossy‐Wetzel, E., Bravo, R., & Hanahan, D. (1992) · Genes & Development · doi:10.1101/gad.6.12a.2340 · Cited by 77 · see citing works
Self-citationAaltomaa, S. H., Lipponen, P., Papinaho, S., & Kosma, V. M. (1993) · PubMed · Cited by 74 · see citing works
Caughey, G. H., Raymond, W. W., Bacci, E., Lombardy, R. J., & Tidwell, R. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10193-6 · Cited by 70 · see citing works
Self-citationBashkin, P., Razin, E., Eldor, A., & Vlodavsky, I. (1990) · Blood · doi:10.1182/blood.v75.11.2204.2204 · Cited by 68 · see citing works
Jm, A., Olson, D., & Hanahan, D. (1996) · PubMed · Cited by 68 · see citing works
Self-citationHanahan, D. (1998) · Nature Medicine · doi:10.1038/nm0198-013 · Cited by 63 · see citing works
Self-citationWastling, J. M., Scudamore, C. L., Thornton, E. M., Newlands, G. F. J., & Miller, H. R. P. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00155.x · Cited by 60 · see citing works
McGrath, M. E., Hines, W. M., Sakanari, J. A., Fletterick, R. J., & Craik, C. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38162-6 · Cited by 58 · see citing works
Molecular dissection of multi-stage tumorigenesis in transgenic mice.
Christofori, G., & Hanahan, D. (1994) · PubMed · Cited by 54 · see citing works
Self-citationDecrease of mast cells in W/W[v] mice and their increase by bone marrow transplantation
呉, 聰. (1979) · Medical Entomology and Zoology · Cited by 49 · see citing works
Mast cell modulation of tumour cell proliferation in rat mammary adenocarcinoma 13762NF
Dabbous, M., Haney, L., Nicolson, G., Eckley, D., & Woolley, D. E. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.192 · Cited by 47 · see citing works
Caughey, G. H., Viro, N. F., Calonico, L. D., McDonald, D. M., Lazarus, S. C., & Gold, W. M. (1988) · Journal of Histochemistry & Cytochemistry · doi:10.1177/36.8.3134486 · Cited by 46 · see citing works
Self-citationMast Cells and Tumor-Associated Angiogenesis
Meininger, C. J. (1995) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000319306 · Cited by 44 · see citing works
Post-transcriptional Regulation of Chymase Expression in Mast Cells
Xia, Z., Ghildyal, N., Austen, K. F., & Stevens, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8747 · Cited by 44 · see citing works
Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor
Jippo, T., Ushio, H., Hirota, S., Mizuno, H., Yamatodani, A., Nomura, S., Matsuda, H., & Kitamura, Y. (1994) · Blood · doi:10.1182/blood.v84.9.2977.2977 · Cited by 42 · see citing works
Structural organization of the murine c-kit proto-oncogene.
Gokkel, E., Grossman, Z., Ramot, B., Yarden, Y., Rechavi, G., & Givol, D. (1992) · PubMed · Cited by 42 · see citing works
Adler, R. R., Brenner, C. A., & Werb, Z. (1990) · Development · doi:10.1242/dev.110.1.211 · Cited by 41 · see citing works
Self-citationMast cells in angiolipomas and hemangiomas of human skin: are they important for angiogenesis?
Shea, C. R., & Prieto, V. G. (1994) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1994.tb00268.x · Cited by 30 · see citing works
Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor
Jippo, T., Ushio, H., Hirota, S., et al. (1994) · Blood · doi:10.1182/blood.v84.9.2977.bloodjournal8492977 · Cited by 8 · see citing works
Cells involved in the immune response
Talor, E., & Richter, M. (1988) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(88)90079-7 · Cited by 7 · see citing works
Earle, K., Pancholi, S., Vernon, P., & Yudkin, J. S. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199808)176:2 · Cited by 2 · see citing works
Laig-Webster, M., Coussens, L. M., Hanahan, D., & Caughey, G. H. (1998) · The FASEB Journal · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Caughey, G.H. 1995. Mast cell chymases and tryptases: Phylog- eny, family relations, and biogenesis. In Mast cell proteases in immunology and biology (ed. G.H. Caughey), pp. 305- 329.
- Folkman, J. and D. Hanahan. 1991. Expression of the angiogenic phenotype during development of murine and human can- cer. In Origins of human cancer: A comprehensive review (ed. J. Brugge, J. Curran, E. Harlow, and F. McCormick), pp. 803-814. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
- Westphal, E. 1891. Uber mastzellen. In Farbenanalytische Ut- ersuchuugen zur Histologie und Klinik des Blutes: gesam- melte Mitt(h)eilungen (ed. P. Ehrlich), Vol. 1, p. 17. Hirsch- wald Press, Berlin, Germany.
Cited by
Sorted by citations
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Self-citationCoussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
“Genetic and functional experiments indicate that neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokine”
Self-citationMantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070 · see citing works
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works
“Recruitment of mast cells to human papilloma virus-induced squamous carcinomas (Coussens et al., 1999) or Myc-induced pancreatic b cell tumors (Soucek et al., 2007) is required for macroscopic tumor expansion; treatment with mast cell inhibitors results in impaired induction and persistence of…”
Self-citationAngiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works
“Tissue fibrosis influences tumor progression by regulating soluble factors that induce inflammation and angiogenesis and stimulate cell growth and invasion (Bierie et al., 2009; Coussens et al., 1999).”
BackgroundMechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,146 · see citing works
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works
Tumorigenesis and the angiogenic switch
Bergers, G., & Benjamin, L. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1093 · Cited by 3,559 · see citing works
“, which develop pancreatic-islet carcinomas, and K14-HPV16 mice, which develop squamous-cell carcinomas of the skin and cervi”
Self-citationTumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,365 · see citing works
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797 · see citing works
Self-citationInfluence of tumour micro-environment heterogeneity on therapeutic response
Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694 · see citing works
Paradoxical roles of the immune system during cancer development
de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,261 · see citing works
“Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant skin lesions contain, predominantly, infiltrating mast cells and granulocyte”
BackgroundSelf-citationHepatocellular carcinoma pathogenesis: from genes to environment
Farazi, P. A., & DePinho, R. A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1934 · Cited by 1,979 · see citing works
“Along these lines, intra-tumoral immunocytes have been shown to enable the angiogenic switc”
BackgroundMicroenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847 · see citing works
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769 · see citing works
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works
The role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642 · see citing works
“Coussens and colleagues also showed that premalignant angiogenesis is decreased in HPV16-derived cutaneous squamous cell carcinoma in MC-deficient transgenic mice compared with their wild-type counterpart”
BackgroundHypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520 · see citing works
Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515 · see citing works
“By 4 months of age, at sites where skin tissue is focally dysplastic, the dermis is transformed into a reactive stroma, composed of blood and lymphatic vessels, inflammatory cells, and fibroblasts, which persists during neoplastic progression to cancer (Coussens et al., 1999) (Figure 1A).”
BackgroundSelf-citationMMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306 · see citing works
Self-citationMAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,231 · see citing works
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
Egeblad, M., Nakasone, E. S., & Werb, Z. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.012 · Cited by 1,230 · see citing works
“Mast cells infiltrate hyperplasias and invasive fronts of carcinomas, where they degranulate close to capillaries, releasing mast cell-specific proteinases, which can stimulate fibroblast proliferation and induce angiogenesis via MMP9 activation (Coussens et al., 1999).”
Self-citationImmunological hallmarks of stromal cells in the tumour microenvironment
Turley, S. J., Cremasco, V., & Astarita, J. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3902 · Cited by 1,140 · see citing works
Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer
Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-N., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1278 · Cited by 1,074 · see citing works
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F. H., Reynolds, C. A., Zimmerman, R. A., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,053 · see citing works
Inflammation, a Key Event in Cancer Development
Lu, H., Ouyang, W., & Huang, C. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0261 · Cited by 1,031 · see citing works
“TAMs may also facilitate tumor cell invasion and metastasis by releasing matrix metalloproteinases (MMP-2 and MMP-9), which degrade the extracellular matrix and the basement membrane (43, 84).”
BackgroundThe hypoxic tumour microenvironment
Petrova, V., Annicchiarico‐Petruzzelli, M., Melino, G., & Amelio, I. (2018) · Oncogenesis · doi:10.1038/s41389-017-0011-9 · Cited by 1,035 · see citing works
TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT
Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 981 · see citing works
Self-citationDePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951 · see citing works
Nozawa, H., Chiu, C. W., & Hanahan, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601807103 · Cited by 926 · see citing works
Self-citationMast-cell responses to pathogens
Marshall, J. S. (2004) · Nature reviews. Immunology · doi:10.1038/nri1460 · Cited by 862 · see citing works
“There is also evidence of a long-term interaction between mast cells and blood vessels, leading to the involvement of mast cells in ANGIOGENESIS”
BackgroundRas-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 854 · see citing works
Palucka, A. K., & Coussens, L. M. (2016) · Cell · doi:10.1016/j.cell.2016.01.049 · Cited by 843 · see citing works
Self-citationDe novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 826 · see citing works
Self-citationMatrix metalloproteinases in tumor invasion and metastasis
Stamenkovic, I. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0379 · Cited by 809 · see citing works
Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796 · see citing works
Toll-like receptors and cancer
Rakoff-Nahoum, S., & Medzhitov, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2541 · Cited by 925 · see citing works
Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics
Jope, R. S., Yuskaitis, C. J., & Beurel, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9128-5 · Cited by 774 · see citing works
“On the other hand, attenuation of innate inflammation following GSK3 inhibition could explain the absence of an effect of lithium alone on tumor formation, since in the absence of infiltration of immune cells, components of tumor development, such as increased cell survival, tissue remodeling, angiogenesis, and suppre…”
BackgroundTargeting the tumour vasculature: insights from physiological angiogenesis
Chung, A. S., Lee, J., & Ferrara, N. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2868 · Cited by 751 · see citing works
“Mast cells promote MMP9-dependent neovascularization of dysplastic tissue and are necessary for triggering the angiogenic switch in a mouse model of skin cance”
BackgroundNew developments in mast cell biology
Kalesnikoff, J., & Galli, S. J. (2008) · Nature Immunology · doi:10.1038/ni.f.216 · Cited by 749 · see citing works
“Experiments with WBB6F 1 - Kit W/W-v mice have provided evidence that mast cells can facilitate angiogenesis during early stages of skin carcinogenesi”
BackgroundTanaka, T., Kohno, H., Suzuki, R., Yamada, Y., Sugie, S., & Mori, H. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01386.x · Cited by 732 · see citing works
The platelet contribution to cancer progression
Bambace, N. M., & Holmes, C. E. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04131.x · Cited by 707 · see citing works
Mast cells as sources of cytokines, chemokines, and growth factors
Mukai, K., Tsai, M. M., Saito, H., & Galli, S. J. (2018) · Immunological Reviews · doi:10.1111/imr.12634 · Cited by 687 · see citing works
DeNardo, D. G., & Coussens, L. M. (2007) · Breast Cancer Research · doi:10.1186/bcr1746 · Cited by 677 · see citing works
“This regulation is exemplified by positive correlations between numbers of innate immune cells (macrophages, mast cells and neutrophils) infiltrating human tumors with the number of blood vessels [81,82], and by experimental findings in mouse models where attenuating innate immune cell infiltration of premalignant tis…”
BackgroundSelf-citationQian, B., Deng, Y., Im, J. H., Muschel, R. J., Zou, Y., Li, J., Lang, R. A., & Pollard, J. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006562 · Cited by 664 · see citing works
“whereby particular classes of cells are ablated in the tumor have revealed major roles for mast cells and macrophages in tumor progression and for macrophages in promoting metastasis [14,15,16].”
BackgroundGelatinase-mediated migration and invasion of cancer cells
Björklund, M., & Koivunen, E. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.03.001 · Cited by 663 · see citing works
“Chymotrypsin-like proteinase in human skin (Han et al., 2002) and mast cell derived α and β chymase (Coussens et al., 1999; Fang et al., 1997) have also been reported to activate MMP-9.”
Backgroundda Silva, E. Z. M., Jamur, M. C., & Oliver, C. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414545334 · Cited by 607 · see citing works
“Mast cells also secrete proteases such as MMP-2 and MMP-9, which digest ECM and, together with heparin, stimulate heparin-binding pro-angiogenic factors in the tumor microenvironment, thus influencing tumor progression and metastasis (Coussens et al. 1999; Baram et al. 2001; Norrby 2002).”
BackgroundGene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems
Birgersdotter, A., Sandberg, R., & Ernberg, I. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.009 · Cited by 591 · see citing works
Grimbaldeston, M. A., Chen, C., Piliponsky, A. M., Tsai, M. M., Tam, S., & Galli, S. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62055-x · Cited by 594 · see citing works
FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
Andreu, P., Johansson, M., Affara, N. I., Pucci, F., Tan, T., Junankar, S. R., Korets, L. V., Lam, J., Tawfik, D., DeNardo, D. G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.019 · Cited by 592 · see citing works
“FcγRIII+ mast cells regulate tissue remodeling, angiogenesis, and keratinocyte hyperproliferation in HPV16 mice (Coussens et al., 1999; Coussens et al., 2000), thus we evaluated whether FcRγ-dependent activation of mast cells was in part necessary for neoplastic progression.”
InfluentialSelf-citationGiraudo, E., Inoue, M., & Hanahan, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422087 · Cited by 700 · see citing works
“from cervices and RT-PCR was performed as previously described (18)”
MethodResultInfluentialSelf-citationComparative biology of mouse versus human cells: modelling human cancer in mice
Rangarajan, A., & Weinberg, R. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1235 · Cited by 567 · see citing works
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
Elenbaas, B., & Weinberg, R. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5133 · Cited by 557 · see citing works
Tumor Immunology and Tumor Evolution: Intertwined Histories
Galon, J., & Bruni, D. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.018 · Cited by 541 · see citing works
A history of exploring cancer in context
Maman, S., & Witz, I. P. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0006-7 · Cited by 502 · see citing works
Galli, S. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00007 · Cited by 521 · see citing works
Fazel, S. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27019 · Cited by 516 · see citing works
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
DeNardo, D. G., Andreu, P., & Coussens, L. M. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9223-6 · Cited by 513 · see citing works
“Our own work has demonstrated that CD4+ TH2 cells in mammary tumors promote M2 responses in TAM and IMCs that in turn enhance pulmonary metastasis [25].”
BackgroundInfluentialSelf-citationComplex roles of tissue inhibitors of metalloproteinases in cancer
Jiang, Y., Goldberg, I. D., & Shi, Y. E. (2002) · Oncogene · doi:10.1038/sj.onc.1205291 · Cited by 508 · see citing works
“The overproduction and unrestrained activity of MMPs have been linked to malignant conversion of tumor cells (Bernhard et al., 1994; Koshiba et al., 1998; Sehgal et al., 1998; Coussens et al., 1999; Sternlicht et al., 1999; Coussens et al., 2000).”
BackgroundSoucek, L., Lawlor, E. R., Soto, D., Shchors, K., Swigart, L. B., & Evan, G. I. (2007) · Nature Medicine · doi:10.1038/nm1649 · Cited by 508 · see citing works
Venneri, M. A., Palma, M. D., Ponzoni, M., Pucci, F., Scielzo, C., Zonari, E., Mazzieri, R., Doglioni, C., & Naldini, L. (2007) · Blood · doi:10.1182/blood-2006-10-053504 · Cited by 504 · see citing works
Genetically engineered mouse models in oncology research and cancer medicine
Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502 · see citing works
“More-over, studies in the K14-HPV16 model have shown that mast cells and bone marrow-derived cells promote squamous skin cancer by activating angiogenesis and by reorganizing stromal architecture via MMP9 (Coussens et al , 1999, 2000).”
Inflammation-induced DNA damage, mutations and cancer
Kay, J. E., Thadhani, E., Samson, L. D., & Engelward, B. P. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102673 · Cited by 481 · see citing works
“tumors can even generate their own inflammatory microenvironment to facilitate growth (7, 25, 26).”
BackgroundMast cell tryptases and chymases in inflammation and host defense.
Caughey, G. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00509.x · Cited by 442 · see citing works
Self-citationVascular Growth Factors and Lymphangiogenesis
Jussila, L., & Alitalo, K. K. (2002) · Physiological Reviews · doi:10.1152/physrev.00005.2002 · Cited by 439 · see citing works
Mast cells promote atherosclerosis by releasing proinflammatory cytokines
Sun, J., Sukhova, G. K., Wolters, P. J., Yang, M., Kitamoto, S., Libby, P., MacFarlane, L. A., Clair, J. M., & Shi, G. (2007) · Nature Medicine · doi:10.1038/nm1601 · Cited by 425 · see citing works
“In an immunoblot analysis, this antibody recognized a 29-kDa band corresponding to mMCP-4 in human papillomavirus transgenic ( Hpv tg ) mouse ear tissue extract”
BackgroundDeryugina, E. I., & Quigley, J. P. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.04.004 · Cited by 424 · see citing works
“By using mast cell-deficient transgenic mice, the infiltration by mast cells delivering MMP-9activating proteases was linked to the MMP-9-mediated angiogenic switch and resulting tumor angiogenesis in the skin carcinogenesis model (Coussens et al., 1999).”
BackgroundKnow thy neighbor: stromal cells can contribute oncogenic signals
Tlsty, T. D., & Hein, P. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00156-8 · Cited by 425 · see citing works
The pre-metastatic niche: finding common ground
Sceneay, J., Smyth, M. J., & Möller, A. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9420-1 · Cited by 422 · see citing works
“The induction of angiogenesis for example, is cruci al to the development and growth of solid tumors and results in the production of ma ny pro-angiogenic TDSFs including VEGF and PlGF from tumor cells and surrou nding stromal cells such as bone marrow-derived macrophages [12], neutrophils [ 13] and mast cells [14].”
BackgroundNew insights into the role of extracellular matrix during tumor onset and progression
Pupa, S. M., Ménard, S., Forti, S., & Tagliabue, E. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10142 · Cited by 420 · see citing works
“However, in the remodeling process, most enzymes are produced by stromal cells of the host (Crawford and Matrisian, 1996; Saren et al., 1996).”
BackgroundMacrophages define the invasive microenvironment in breast cancer
Pollard, J. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107762 · Cited by 414 · see citing works
“by these cells [9, 13].”
BackgroundCytokines in cancer immunity and immunotherapy
Smyth, M. J., Cretney, E., Kershaw, M. H., & Hayakawa, Y. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00199.x · Cited by 413 · see citing works
Albini, A., Bruno, A., Noonan, D. M., & Mortara, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00527 · Cited by 393 · see citing works
“MC deficient tumor-bearing mice show a reduced angiogenesis and metastatic capacity (138, 139).”
BackgroundCoussens, L. M., & Werb, Z. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.f23 · Cited by 384 · see citing works
“Mast cells and neutrophils also potentiate the actions of oncogenes encoded by human papillomavirus type 16 (HPV16) in transgenic mice predisposed to squamous carcinoma development (19, 23).”
BackgroundSelf-citationNorrby, K. (2002) · Apmis · doi:10.1034/j.1600-0463.2002.100501.x · Cited by 378 · see citing works
“Inflammatory cells including mast cells are therefore critical suppliers of MMP-9 to this carcinogenesis pathway (20, 95).”
BackgroundInfluentialImmune cells as mediators of solid tumor metastasis
DeNardo, D. G., Johansson, M., & Coussens, L. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9100-0 · Cited by 370 · see citing works
“In addition, MCs indirectly stimulate angiogenesis by secreting serine proteases (chymases and tryptases) that can activate pro-MMPs and stimulate fibroblast proliferation and fibrillar collagen synthesis [21, 30, 43, 44].”
BackgroundSelf-citationKenny, H. A., Kaur, S., Coussens, L. M., & Lengyel, E. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33775 · Cited by 370 · see citing works
Self-citationBremnes, R. M., Al-Shibli, K. I., Dønnem, T., Sirera, R., Al‐Saad, S., Andersen, S., Stenvold, H., Camps, C., & Busund, L. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182037b76 · Cited by 369 · see citing works
The metastasis-promoting roles of tumor-associated immune cells
Smith, H. A., & Kang, Y. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1021-5 · Cited by 367 · see citing works
Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/−- and c-kit-Dependent Bone Marrow
Yang, F., Ingram, D. A., Shi, C., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S. M., Horn, W., Li, Y., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.041 · Cited by 363 · see citing works
Mast cells in atopic dermatitis
Kawakami, T., Ando, T., Kimura, M., Wilson, B. S., & Kawakami, Y. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.09.006 · Cited by 362 · see citing works
“Current Opinion in Immunology 2009, 21:666–678 autoimmune diseases [8,9], allograft tolerance [10], angiogenesis in tissue repair [11], and carcinogenesis [12,13].”
BackgroundHuang, S. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.15.1134 · Cited by 345 · see citing works
Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer
Kerkelä, E., & Saarialho‐Kere, U. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.120201.x · Cited by 343 · see citing works
“For example, MMP-7 and -9 may both induce tumor angiogenesis or inhibit it by generation of angiostatin (48,109,179).”
BackgroundLiang, W., Wu, X., Peale, F. V., Jr., Lee, C. V., Meng, Y. G., Gutierrez, J., Fu, L., Malik, A. K., Gerber, H., Ferrara, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508199200 · Cited by 345 · see citing works
Rakoff-Nahoum, S. (2006) · PubMed Central · Cited by 343 · see citing works
Cytokines as a key component of cancer-related inflammation
Germano, G., Allavena, P., & Mantovani, A. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.014 · Cited by 331 · see citing works
Tumor-Host Interactions: A Far-Reaching Relationship
McAllister, S. S., & Weinberg, R. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.4257 · Cited by 326 · see citing works
Immune escape as a fundamental trait of cancer: focus on IDO
Prendergast, G. C. (2008) · Oncogene · doi:10.1038/onc.2008.35 · Cited by 325 · see citing works
“, 2006) may serve an important role in epithelial tumorigenesis (Coussens et al., 1999; Muto et al., 2007; Soucek et al., 2007).”
BackgroundMonocyte/macrophage infiltration in tumors: modulators of angiogenesis
Dirkx, A. E. M., Egbrink, M. G. A. O., Wagstaff, J., & Griffioen, A. W. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905495 · Cited by 326 · see citing works
Cancer and Inflammation: Promise for Biologic Therapy
Demaria, S., Pikarsky, E., Karin, M., Coussens, L. M., Chen, Y., El-Omar, E. M., Trinchieri, G., Dubinett, S. M., Mao, J. T., Szabo, E. M., et al. (2010) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181d32e74 · Cited by 325 · see citing works
“Preclinical data suggest that they contribute to tumor progression, perhaps by promoting angiogenesis.(15,16) However, clinical data are contradictory showing association of mast cell numbers with poor survival in some studies, and with improved survival in others.”
BackgroundSelf-citationTchougounova, E., Lundequist, A., Fajardo, I., Winberg, J., Åbrink, M., & Pejler, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410396200 · Cited by 344 · see citing works
Are Mast Cells MASTers in Cancer?
Varricchi, G., Galdiero, M. R., Loffredo, S., Marone, G., Iannone, R., Marone, G., & Granata, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00424 · Cited by 322 · see citing works
“Skin Chloroacetate esterase/hematoxylin (98)”
BackgroundMethodPejler, G., Åbrink, M., Ringvall, M., & Wernersson, S. (2007) · Advances in immunology · doi:10.1016/s0065-2776(07)95006-3 · Cited by 324 · see citing works
Stromal cells can contribute oncogenic signals
Tlsty, T. D. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0361 · Cited by 322 · see citing works
Stromal biology of pancreatic cancer
Chu, G. C., Kimmelman, A. C., Hezel, A. F., & DePinho, R. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21209 · Cited by 321 · see citing works
“As in a mouse model of squamous epithelial carcinogenesis [Bergers et al., 1998; Coussens et al., 1999, 2000; Hoffman et al., 2003], one might speculate that the stroma around the in situ PanINs may promote tumor growth, angiogenesis, ECM remodeling, and assist in tumor invasion, although a neutral…”
BackgroundWatnick, R. S., Cheng, Y.-N., Rangarajan, A., Ince, T. A., & Weinberg, R. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00030-8 · Cited by 316 · see citing works
RetractedThree-dimensional context regulation of metastasis
Erler, J. T., & Weaver, V. M. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9209-8 · Cited by 314 · see citing works
B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas
Affara, N. I., Ruffell, B., Medler, T. R., Gunderson, A. J., Johansson, M., Bornstein, S., Bergsland, E. K., Steinhoff, M. S., Li, Y., Gong, Q., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.026 · Cited by 305 · see citing works
“…of multistage epithelial carcinogenesis where HPV16 early region genes are expressed under control of a K14 promoter, i.e., K14-HPV16 mice (Arbeit et al., 1994; Coussens et al., 1996, 1999,2000; Daniel et al., 2003; de Visser et al., 2004, 2005; Rhee et al., 2004; van Kempen et al., 2002).”
Self-citation
- Authors
- Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-01
- Volume
- 13
- Issue
- 11
- Pages
- 1382-1397
- ISSN
- 0890-9369 (ISSN-L)
- PMC
- PMC316772
- OpenAlex
- W2146440075
- Cited by
- 946
- References
- 87
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 11 · 2023: 13 · 2022: 27 · 2021: 18 · 2020: 29 · 2019: 31 · 2018: 27 · 2017: 29 · 2016: 39 · 2015: 32 · 2014: 52 · 2013: 32 · 2012: 49
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 24136, P01HL024136)
- National Cancer Institute (CA72006, P01CA072006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- mast cells, angiogenesis, squamous cell carcinoma, HPV16, keratinocytes, MMP-9, chymase, tryptase, precancerous lesions, dermal fibroblasts, tumor stroma, inflammation, carcinogenesis, neovascularization
- MeSH terms
- Animals, Carcinoma, Squamous Cell, Extracellular Matrix, Humans, Mast Cells, Mice, Transgenic, Neovascularization, Pathologic, Serine Endopeptidases, Up-Regulation, Inflammation Mediators, Mice, Tryptases, Chymases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
