Gladwin, Mark T.

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersNitric Oxide and Endothelin Effects

Cited by 391

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

Villagra, J., Shiva, S., Hunter, L. A., Machado, R. F., Gladwin, M. T., & Kato, G. J. (2007) · Blood

Hemoglobinopathies and Related DisordersPlatelet Disorders and Treatments

Cited by 384

Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis

Shiva, S., Wang, X., Ringwood, L. A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z. L., & Gladwin, M. T. (2006) · Nature Chemical Biology

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 359

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

Kato, G. J., Hebbel, R. P., Steinberg, M. H., & Gladwin, M. T. (2009) · American Journal of Hematology

Hemoglobinopathies and Related DisordersBlood properties and coagulation

Cited by 349

Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation

Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 334

Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation

Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 329

Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients With Sickle Cell Disease

Sachdev, V., Machado, R. F., Shizukuda, Y., Rao, Y. N., Sidenko, S., Ernst, I., St. Peter, M., Coles, W. A., Rosing, D. R., Blackwelder, W. C., et al. (2007) · Journal of the American College of Cardiology

Hemoglobinopathies and Related DisordersCardiovascular Function and Risk Factors

Cited by 323

Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics

Kim-Shapiro, D. B., Schechter, A. N., & Gladwin, M. T. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 308

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 298

The functional nitrite reductase activity of the heme-globins

Gladwin, M. T., & Kim-Shapiro, D. B. (2008) · Blood

Hemoglobin structure and functionHeme Oxygenase-1 and Carbon Monoxide

Cited by 293

Human neuroglobin functions as a redox-regulated nitrite reductase

Tiso, M., Tejero, J., Basu, S., Azarov, I., Wang, X., Simplaceanu, V., Frizzell, S., Jayaraman, T., Geary, L., Shapiro, C., et al. (2011) · Journal of Biological Chemistry

Hemoglobin structure and functionHeme Oxygenase-1 and Carbon Monoxide

Cited by 287

Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator

Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine

Pulmonary Hypertension Research and TreatmentsNeonatal Respiratory Health Research

Cited by 281

SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., et al. (2016) · Circulation

Pulmonary Hypertension Research and TreatmentsSirtuins and Resveratrol in Medicine

Cited by 270

Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

Hsu, L. L., Champion, H. C., Campbell-Lee, S. A., Bivalacqua, T. J., Manci, E. A., Diwan, B. A., Schimel, D. M., Cochard, A. E., Wang, X., Schechter, A. N., et al. (2007) · Blood

Hemoglobinopathies and Related DisordersNitric Oxide and Endothelin Effects

Cited by 263

The Reaction between Nitrite and Deoxyhemoglobin

Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., & Hogg, N. (2005) · Journal of Biological Chemistry

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 253

Mortality in Adults With Sickle Cell Disease and Pulmonary Hypertension

Mehari, A., Gladwin, M. T., Tian, X., Machado, R. F., & Kato, G. J. (2012) · JAMA

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 229

Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin

Basu, S., Grubina, R., Huang, J., Conradie, J., Huang, Z., Jeffers, A., Jiang, A., He, X., Azarov, I., Seibert, R., et al. (2007) · Nature Chemical Biology

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 224

Emerging role of nitrite in human biology

Dejam, A., Hunter, C. J., Schechter, A. N., & Gladwin, M. T. (2004) · Blood Cells, Molecules, and Diseases

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 221

Nitrite reductase activity of cytochrome c

Basu, S., Azarova, N. A., Font, M. D., King, S. B., Hogg, N., Gladwin, M. T., Shiva, S., & Kim-Shapiro, D. B. (2008) · Journal of Biological Chemistry

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 214

Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation

Totzeck, M., Hendgen-Cotta, U. B., Luedike, P., Berenbrink, M., Klare, J. P., Steinhoff, H.-J., Semmler, D., Shiva, S., Williams, D., Kipar, A., et al. (2012) · Circulation

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 202

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics

DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research

Nitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion

Cited by 198

N-Terminal Pro-Brain Natriuretic Peptide Levels and Risk of Death in Sickle Cell Disease

Machado, R. F., Anthi, A., Steinberg, M. H., Bonds, D., Sachdev, V., Kato, G. J., Taveira-DaSilva, A. M., Ballas, S. K., Blackwelder, W., Xu, X., et al. (2006) · JAMA

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 197

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

Gladwin, M. T., Kanias, T., & Kim-Shapiro, D. B. (2012) · Journal of Clinical Investigation

Blood transfusion and managementHemoglobin structure and function

Cited by 196

The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase

Gladwin, M. T., Grubina, R., & Doyle, M. P. (2009) · Accounts of Chemical Research

Hemoglobin structure and functionMetal-Catalyzed Oxygenation Mechanisms

Cited by 194