Gladwin, Mark T.

Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation

Zuckerbraun, B. S., Shiva, S., Ifedigbo, E., Mathier, M. A., Mollen, K. P., Rao, J., Bauer, P. M., Choi, J. J. W., Curtis, E., Choi, A. M. K., et al. (2010) · Circulation

Pulmonary Hypertension Research and TreatmentsNitric Oxide and Endothelin Effects

Cited by 192

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsOral microbiology and periodontitis research

Cited by 186

Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction

Gonzalez, F. M., Shiva, S., Vincent, P. S., Ringwood, L. A., Hsu, L.-Y., Hon, Y. Y., Aletras, A. H., Cannon, R. O., Gladwin, M. T., & Arai, A. E. (2008) · Circulation

Cardiac Ischemia and ReperfusionNitric Oxide and Endothelin Effects

Cited by 175

Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I

Dezfulian, C., Shiva, S., Alekseyenko, A., Pendyal, A., Beiser, D. G., Munasinghe, J. P., Anderson, S. A., Chesley, C. F., Vanden Hoek, T. L., & Gladwin, M. T. (2009) · Circulation

Cardiac Arrest and ResuscitationCardiac Ischemia and Reperfusion

Cited by 174

Cardiovascular complications and risk of death in sickle-cell disease

Gladwin, M. T. (2016) · The Lancet

Hemoglobinopathies and Related DisordersBlood properties and coagulation

Cited by 164

Biological activity of nitric oxide in the plasmatic compartment

Wang, X., Tanus-Santos, J. E., Reiter, C. D., Dejam, A., Shiva, S., Smith, R. D., Hogg, N., & Gladwin, M. T. (2004) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 164

S-Nitrosohemoglobin Is Unstable in the Reductive Erythrocyte Environment and Lacks O2/NO-linked Allosteric Function

Gladwin, M. T., Wang, X., Reiter, C. D., Yang, B. K., Vivas, E. X., Bonaventura, C., & Schechter, A. N. (2002) · Journal of Biological Chemistry

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 160

Mechanisms of nitrite bioactivation

Kim-Shapiro, D. B., & Gladwin, M. T. (2014) · Nitric Oxide

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 157

Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom

Sachdev, V., Kato, G. J., Gibbs, J. S. R., Barst, R. J., Machado, R. F., Nouraie, M., Hassell, K. L., Little, J. A., Schraufnagel, D. E., Krishnamurti, L., et al. (2011) · Circulation

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 147

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli

Bennewitz, M. F., Jimenez, M. A., Vats, R., Tutuncuoglu, E., Jonassaint, J., Kato, G. J., Gladwin, M. T., & Sundd, P. (2017) · JCI Insight

Hemoglobinopathies and Related DisordersPlatelet Disorders and Treatments

Cited by 139

Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe

Maitra, P., Caughey, M., Robinson, L., Desai, P. C., Jones, S., Nouraie, M., Gladwin, M. T., Hinderliter, A., Cai, J., & Ataga, K. I. (2017) · Haematologica

Hemoglobinopathies and Related DisordersBlood groups and transfusion

Cited by 137

Risk Factors for Death in 632 Patients with Sickle Cell Disease in the United States and United Kingdom

Gladwin, M. T., Barst, R. J., Gibbs, J. S. R., Hildesheim, M., Sachdev, V., Nouraie, M., Hassell, K. L., Little, J. A., Schraufnagel, D. E., Krishnamurti, L., et al. (2014) · PLoS ONE

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 132

Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia

Saraf, S. L., Zhang, X., Kanias, T., Lash, J. P., Molokie, R. E., Oza, B., Lai, C., Rowe, J. H., Gowhari, M., Hassan, J., et al. (2014) · British Journal of Haematology

Hemoglobinopathies and Related DisordersChronic Kidney Disease and Diabetes

Cited by 120

An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

Voraphani, N., Gladwin, M. T., Contreras, A. U., Kaminski, N., Tedrow, J. R., Milosevic, J., Bleecker, E. R., Meyers, D. A., Ray, A., Ray, P., et al. (2014) · Mucosal Immunology

Asthma and respiratory diseasesRedox biology and oxidative stress

Cited by 119

Erythroid DAMPs drive inflammation in SCD

Gladwin, M. T., & Ofori-Acquah, S. F. (2014) · Blood

Hemoglobinopathies and Related DisordersNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 113

The Perfusion Paradox and Vascular Instability in Sickle Cell Disease

NATH, K. A., KATUSIC, Z. S., & GLADWIN, M. T. (2004) · Microcirculation

Hemoglobinopathies and Related DisordersBlood properties and coagulation

Cited by 102

Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats

Alef, M. J., Vallabhaneni, R., Carchman, E., Morris, S. M., Shiva, S., Wang, Y., Kelley, E. E., Tarpey, M. M., Gladwin, M. T., Tzeng, E., et al. (2011) · Journal of Clinical Investigation

Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in Cancer

Cited by 101

Cerebrovascular disease associated with sickle cell pulmonary hypertension

Kato, G. J., Hsieh, M., Machado, R., Taylor, J., Little, J., Butman, J. A., Lehky, T., Tisdale, J., & Gladwin, M. T. (2006) · American Journal of Hematology

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 100

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

Delmastro-Greenwood, M., Hughan, K. S., Vitturi, D. A., Salvatore, S. R., Grimes, G., Potti, G., Shiva, S., Schopfer, F. J., Gladwin, M. T., Freeman, B. A., et al. (2015) · Free Radical Biology and Medicine

Fatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

Cited by 97

Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response

Raat, N. J. H., Noguchi, A. C., Liu, V. B., Raghavachari, N., Liu, D., Xu, X., Shiva, S., Munson, P. J., & Gladwin, M. T. (2009) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion

Cited by 97

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity

Kelley, E. E., Baust, J., Bonacci, G., Golin-Bisello, F., Devlin, J. E., St. Croix, C. M., Watkins, S. C., Gor, S., Cantu-Medellin, N., Weidert, E. R., et al. (2014) · Cardiovascular Research

Cardiovascular Disease and AdiposityPulmonary Hypertension Research and Treatments

Cited by 95

Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop

Ahluwalia, A., Gladwin, M., Coleman, G. D., Hord, N., Howard, G., Kim‐Shapiro, D. B., Lajous, M., Larsen, F. J., Lefer, D. J., McClure, L. A., et al. (2016) · Journal of the American Heart Association

Nutritional Studies and DietNitric Oxide and Endothelin Effects

Cited by 92

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

Katz, D. H., Tahir, U. A., Bick, A. G., Pampana, A., Ngo, D., Benson, M. D., Yu, Z., Robbins, J. M., Chen, Z.-Z., Cruz, D. E., et al. (2022) · Circulation

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 92

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling

Rahaman, M. M., Nguyen, A. T., Miller, M. P., Hahn, S. A., Sparacino-Watkins, C., Jobbagy, S., Carew, N. T., Cantu-Medellin, N., Wood, K. C., Baty, C. J., et al. (2017) · Circulation Research

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 92