Pandolfi, Pier Paolo

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell

Cancer-related molecular mechanisms researchRNA Research and Splicing

Cited by 7,262

The multilayered complexity of ceRNA crosstalk and competition

Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature

Cancer-related molecular mechanisms researchMicroRNA in disease regulation

Cited by 3,910

The functions and regulation of the PTEN tumour suppressor

Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,926

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature

Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

Cited by 1,712

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics

Systemic Lupus Erythematosus ResearchComplement system in diseases

Cited by 1,434

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C., et al. (2008) · Journal of Clinical Investigation

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,381

Phosphorylation and Functional Inactivation of TSC2 by Erk

Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., & Pandolfi, P. P. (2005) · Cell

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 1,268

The Multiple Roles of PTEN in Tumor Suppression

Di Cristofano, A., & Pandolfi, P. P. (2000) · Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,182

Essential role for nuclear PTEN in maintaining chromosomal integrity

Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., & Yin, Y. (2007) · Cell

DNA Repair MechanismsMicrotubule and mitosis dynamics

Cited by 979

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell

Cancer, Hypoxia, and MetabolismSirtuins and Resveratrol in Medicine

Cited by 782

Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N. P., Carver, B. S., Cordon-Cardo, C., Erdjument-Bromage, H., et al. (2007) · Cell

PI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathways

Cited by 748

Single-cell genomics unveils critical regulators of Th17 cell pathogenicity

Gaublomme, J. T., Yosef, N., Lee, Y., Gertner, R. S., Yang, L. V., Wu, C., Pandolfi, P. P., Mak, T., Satija, R., Shalek, A. K., et al. (2015) · Cell

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 575

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J., & Pandolfi, P. P. (2008) · Nature

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 548

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

Xie, H., Hanai, J.-I., Ren, J.-G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., et al. (2014) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 516

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Chen, Z., Cheng, K., Walton, Z., Wang, Y., Ebi, H., Shimamura, T., Liu, Y., Tupper, T., Ouyang, J., Li, J., et al. (2012) · Nature

Lung Cancer Treatments and MutationsLung Cancer Research Studies

Cited by 446

Pro-senescence therapy for cancer treatment

Nardella, C., Clohessy, J. G., Alimonti, A., & Pandolfi, P. P. (2011) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 437

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

Kogan, S. C., Ward, J. M., Anver, M. R., Berman, J. J., Brayton, C., Cardiff, R. D., Carter, J. S., de Coronado, S., Downing, J. R., Fredrickson, T. N., et al. (2002) · Blood

Acute Myeloid Leukemia ResearchVeterinary Oncology Research

Cited by 418

Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

Toso, A., Revandkar, A., Di Mitri, D., Guccini, I., Proietti, M., Sarti, M., Pinton, S., Zhang, J., Kalathur, M., Civenni, G., et al. (2014) · Cell Reports

Telomeres, Telomerase, and SenescenceProstate Cancer Treatment and Research

Cited by 418

Identification of the miR-106b ~ 25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

Poliseno, L., Salmena, L., Riccardi, L., Fornari, A., Song, M. S., Hobbs, R. M., Sportoletti, P., Varmeh, S., Egia, A., Fedele, G., et al. (2010) · Science Signaling

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 410

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Lin, H.-K., Chen, Z., Wang, G., Nardella, C., Lee, S.-W., Chan, C.-H., Yang, W.-L., Wang, J., Egia, A., Nakayama, K. I., et al. (2010) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 400

Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

Tsutsui, T., Hesabi, B., Moons, D. S., Pandolfi, P. P., Hansel, K. S., Koff, A., & Kiyokawa, H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 395

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 374

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 312

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Wei, S., Kozono, S., Kats, L., Nechama, M., Li, W., Guarnerio, J., Luo, M., You, M.-H., Yao, Y., Kondo, A., et al. (2015) · Nature Medicine

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

Cited by 272