Walsh, Christopher A.

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain

Cai, X., Evrony, G. D., Lehmann, H. S., Elhosary, P. C., Mehta, B. K., Poduri, A., & Walsh, C. A. (2014) · Cell Reports

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

Cited by 318

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim, E. T., Uddin, M., De Rubeis, S., Chan, Y., Kamumbu, A. S., Zhang, X., D'Gama, A. M., Kim, S. N., Hill, R. S., Goldberg, A. P., et al. (2017) · Nature Neuroscience

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 299

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

Johnson, M. B., Wang, P. P., Atabay, K. D., Murphy, E. A., Doan, R. N., Hecht, J. L., & Walsh, C. A. (2015) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 288

Cell lineage analysis in human brain using endogenous retroelements

Evrony, G. D., Lee, E., Mehta, B. K., Benjamini, Y., Johnson, R. M., Cai, X., Yang, L., Haseley, P., Lehmann, H. S., Park, P. J., et al. (2015) · Neuron

Genomic variations and chromosomal abnormalitiesSingle-cell and spatial transcriptomics

Cited by 269

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

McConnell, M. J., Moran, J. V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J. A., Fasching, L., Flasch, D. A., Freed, D., et al. (2017) · Science

Genomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Cited by 262

GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination

Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R. O., Walsh, C. A., Corfas, G., & Piao, X. (2008) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological Disorders

Cited by 241

Building a lineage from single cells: genetic techniques for cell lineage tracking

Woodworth, M. B., Girskis, K. M., & Walsh, C. A. (2017) · Nature Reviews Genetics

Developmental Biology and Gene RegulationSingle-cell and spatial transcriptomics

Cited by 236

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

Bae, B.-I., Tietjen, I., Atabay, K. D., Evrony, G. D., Johnson, M. B., Asare, E., Wang, P. P., Murayama, A. Y., Im, K., Lisgo, S. N., et al. (2014) · Science

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 229

Somatic genomic changes in single Alzheimer’s disease neurons

Miller, M. B., Huang, A. Y., Kim, J., Zhou, Z., Kirkham, S. L., Maury, E. A., Ziegenfuss, J. S., Reed, H. C., Neil, J. E., Rento, L., et al. (2022) · Nature

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 223

Comparative transcriptomics reveals human-specific cortical features

Jorstad, N. L., Song, J. H. T., Exposito-Alonso, D., Suresh, H., Castro-Pacheco, N., Krienen, F. M., Yanny, A. M., Close, J., Gelfand, E., Long, B., et al. (2023) · Science

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 208

Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions

Girskis, K. M., Stergachis, A. B., DeGennaro, E. M., Doan, R. N., Qian, X., Johnson, M. B., Wang, P. P., Sejourne, G. M., Nagy, M. A., Pollina, E. A., et al. (2021) · Neuron

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 193

Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation

Yang, Y. J., Baltus, A. E., Mathew, R. S., Murphy, E. A., Evrony, G. D., Gonzalez, D. M., Wang, E. P., Marshall-Walker, C. A., Barry, B. J., Murn, J., et al. (2012) · Cell

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 176

Resolving rates of mutation in the brain using single-neuron genomics

Evrony, G. D., Lee, E., Park, P. J., & Walsh, C. A. (2016) · eLife

Single-cell and spatial transcriptomicsGenomic variations and chromosomal abnormalities

Cited by 163

Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development

Smith, R. S., Kenny, C. J., Ganesh, V., Jang, A., Borges-Monroy, R., Partlow, J. N., Hill, R. S., Shin, T., Chen, A. Y., Doan, R. N., et al. (2018) · Neuron

Ion channel regulation and functionEpilepsy research and treatment

Cited by 160

Recessive gene disruptions in autism spectrum disorder

Autism Sequencing Consortium, Doan, R. N., Lim, E. T., De Rubeis, S., Betancur, C., Cutler, D. J., Chiocchetti, A. G., Overman, L. M., Soucy, A., Goetze, S., et al. (2019) · Nature Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 159

Evolution of Osteocrin as an activity-regulated factor in the primate brain

Ataman, B., Boulting, G. L., Harmin, D. A., Yang, M. G., Baker-Salisbury, M., Yap, E.-L., Malik, A. N., Mei, K., Rubin, A. A., Spiegel, I., et al. (2016) · Nature

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 149

A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?

Chaste, P., Klei, L., Sanders, S. J., Hus, V., Murtha, M. T., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., et al. (2015) · Biological Psychiatry

Autism Spectrum Disorder ResearchGenetic Associations and Epidemiology

Cited by 144

Genetic Changes Shaping the Human Brain

Bae, B.-I., Jayaraman, D., & Walsh, C. A. (2015) · Developmental Cell

Genetics and Neurodevelopmental DisordersGenetic Associations and Epidemiology

Cited by 135

Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism

Chahrour, M. H., Yu, T. W., Lim, E. T., Ataman, B., Coulter, M. E., Hill, R. S., Stevens, C. R., Schubert, C. R., ARRA Autism Sequencing Collaboration, Greenberg, M. E., et al. (2012) · PLoS Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 125

Landmarks of human embryonic development inscribed in somatic mutations

Bizzotto, S., Dou, Y., Ganz, J., Doan, R. N., Kwon, M., Bohrson, C. L., Kim, S. N., Bae, T., Abyzov, A., NIMH Brain Somatic Mosaicism Network, et al. (2021) · Science

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 117

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Luquette, L. J., Miller, M. B., Zhou, Z., Bohrson, C. L., Zhao, Y., Jin, H., Gulhan, D., Ganz, J., Bizzotto, S., Kirkham, S., et al. (2022) · Nature Genetics

Single-cell and spatial transcriptomicsCancer Genomics and Diagnostics

Cited by 108

Biallelic mutations in human DCC cause developmental split-brain syndrome

Jamuar, S. S., Schmitz-Abe, K., D'Gama, A. M., Drottar, M., Chan, W.-M., Peeva, M., Servattalab, S., Lam, A.-T. N., Delgado, M. R., Clegg, N. J., et al. (2017) · Nature Genetics

Fetal and Pediatric Neurological DisordersAxon Guidance and Neuronal Signaling

Cited by 81

Modest Impact on Risk for Autism Spectrum Disorder of Rare Copy Number Variants at 15 q 11.2, Specifically Breakpoints 1 to 2

Chaste, P., Sanders, S. J., Mohan, K. N., Klei, L., Song, Y., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno‐De‐Luca, D., et al. (2014) · Autism Research

Genomic variations and chromosomal abnormalitiesAutism Spectrum Disorder Research

Cited by 61

Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

Lodato, M. A., & Walsh, C. A. (2019) · Human Molecular Genetics

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 56