Iadecola, Costantino

Hypertension: A Harbinger of Stroke and Dementia

Faraco, G., & Iadecola, C. (2013) · Hypertension

Neurological Disease Mechanisms and TreatmentsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 367

Perioperative atrial fibrillation and the long-term risk of ischemic stroke

Gialdini, G., Nearing, K., Bhave, P. D., Bonuccelli, U., Iadecola, C., Healey, J. S., & Kamel, H. (2014) · JAMA

Atrial Fibrillation Management and OutcomesCardiac, Anesthesia and Surgical Outcomes

Cited by 355

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

Faraco, G., Sugiyama, Y., Lane, D., Garcia-Bonilla, L., Chang, H., Santisteban, M. M., Racchumi, G., Murphy, M., Van Rooijen, N., Anrather, J., et al. (2016) · Journal of Clinical Investigation

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 350

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

Faraco, G., Brea, D., Garcia-Bonilla, L., Wang, G., Racchumi, G., Chang, H., Buendia, I., Santisteban, M. M., Segarra, S. G., Koizumi, K., et al. (2018) · Nature Neuroscience

Nitric Oxide and Endothelin EffectsSodium Intake and Health

Cited by 343

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S., et al. (2008) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 332

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

Niwa, K., Kazama, K., Younkin, L., Younkin, S. G., Carlson, G. A., & Iadecola, C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 286

Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse Brain

Park, L., Anrather, J., Girouard, H., Zhou, P., & Iadecola, C. (2007) · Journal of Cerebral Blood Flow & Metabolism

Nitric Oxide and Endothelin EffectsNeurological Disease Mechanisms and Treatments

Cited by 275

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

Park, L., Uekawa, K., Garcia-Bonilla, L., Koizumi, K., Murphy, M., Pistik, R., Younkin, L., Younkin, S., Zhou, P., Carlson, G., et al. (2017) · Circulation Research

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 259

Angiotensin II Impairs Neurovascular Coupling in Neocortex Through NADPH Oxidase–Derived Radicals

Kazama, K., Anrather, J., Zhou, P., Girouard, H., Frys, K., Milner, T. A., & Iadecola, C. (2004) · Circulation Research

Nitric Oxide and Endothelin EffectsRenin-Angiotensin System Studies

Cited by 253

NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide

Park, L., Anrather, J., Zhou, P., Frys, K., Pitstick, R., Younkin, S., Carlson, G. A., & Iadecola, C. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNitric Oxide and Endothelin Effects

Cited by 244

Dietary salt promotes cognitive impairment through tau phosphorylation

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. (2019) · Nature

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 236

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

Kim, Y., Zhou, P., Qian, L., Chuang, J.-Z., Lee, J., Li, C., Iadecola, C., Nathan, C., & Ding, A. (2007) · The Journal of Experimental Medicine

Immune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms

Cited by 234

Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein

Niwa, K., Kazama, K., Younkin, S. G., Carlson, G. A., & Iadecola, C. (2002) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 218

Threats to the Mind: Aging, Amyloid, and Hypertension

Iadecola, C., Park, L., & Capone, C. (2009) · Stroke

Neurological Disease Mechanisms and TreatmentsNitric Oxide and Endothelin Effects

Cited by 207

Brain perivascular macrophages: characterization and functional roles in health and disease

Faraco, G., Park, L., Anrather, J., & Iadecola, C. (2017) · Journal of Molecular Medicine

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 206

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein

Zhang, F., Eckman, C., Younkin, S., Hsiao, K. K., & Iadecola, C. (1997) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAcute Ischemic Stroke Management

Cited by 205

Aβ-peptides enhance vasoconstriction in cerebral circulation

Niwa, K., Porter, V. A., Kazama, K., Cornfield, D., Carlson, G. A., & Iadecola, C. (2001) · American Journal of Physiology-Heart and Circulatory Physiology

Alzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 202

Exogenous Aβ1–40 Reproduces Cerebrovascular Alterations Resulting from Amyloid Precursor Protein Overexpression in Mice

Niwa, K., Carlson, G. A., & Iadecola, C. (2000) · Journal of Cerebral Blood Flow & Metabolism

Alzheimer's disease research and treatmentsNitric Oxide and Endothelin Effects

Cited by 191

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

Koizumi, K., Hattori, Y., Ahn, S. J., Buendia, I., Ciacciarelli, A., Uekawa, K., Wang, G., Hiller, A., Zhao, L., Voss, H. U., et al. (2018) · Nature Communications

Neurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

Cited by 179

Arterial thromboembolic events preceding the diagnosis of cancer in older persons

Navi, B. B., Reiner, A. S., Kamel, H., Iadecola, C., Okin, P. M., Tagawa, S. T., Panageas, K. S., & DeAngelis, L. M. (2019) · Blood

Venous Thromboembolism Diagnosis and ManagementInflammatory Biomarkers in Disease Prognosis

Cited by 179

The role of neuronal signaling in controlling cerebral blood flow

DRAKE, C., & IADECOLA, C. (2007) · Brain and Language

Advanced MRI Techniques and ApplicationsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 177

Translational Stroke Research: Vision and Opportunities

Bosetti, F., Koenig, J. I., Ayata, C., Back, S. A., Becker, K., Broderick, J. P., Carmichael, S. T., Cho, S., Cipolla, M. J., Corbett, D., et al. (2017) · Stroke

Acute Ischemic Stroke ManagementIntracerebral and Subarachnoid Hemorrhage Research

Cited by 171

Hypertension enhances A β -induced neurovascular dysfunction, promotes β -secretase activity, and leads to amyloidogenic processing of APP

Faraco, G., Park, L., Zhou, P., Luo, W., Paul, S. M., Anrather, J., & Iadecola, C. (2016) · Journal of Cerebral Blood Flow & Metabolism

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 158

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

Park, L., Wang, G., Zhou, P., Zhou, J., Pitstick, R., Previti, M. L., Younkin, L., Younkin, S. G., Van Nostrand, W. E., Cho, S., et al. (2011) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 156